Coffee consumption prevents fibrosis in a rat model that mimics secondary biliary cirrhosis in humans

Arauz, Jonathan; Zarco, Natanael; Hernández-Aquino, Erika; Galicia-Moreno, Marina; Favari, Liliana; Segovia, José; Muriel, Pablo

doi:10.1016/j.nutres.2017.03.008

Cited by 21 publications

(13 citation statements)

References 37 publications

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“…174 Although there are no reports of its effects in PH in humans, prophylactic but also therapeutic treatment of BDL-cirrhotic rats with caffeine or caffeinated coffee ameliorated PP, liver inflammation and fibrosis, while also improving the extrahepatic vasculature. 175,176…”

Section: Lifestyle and Dietary Interventionsmentioning

confidence: 99%

Advances in therapeutic options for portal hypertension

Vilaseca

Guixé‐Muntet

Fernández‐Iglesias

et al. 2018

Therap Adv Gastroenterol

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Portal hypertension represents one of the major clinical consequences of chronic liver disease, having a deep impact on patients’ prognosis and survival. Its pathophysiology defines a pathological increase in the intrahepatic vascular resistance as the primary factor in its development, being subsequently aggravated by a paradoxical increase in portal blood inflow. Although extensive preclinical and clinical research in the field has been developed in recent decades, no effective treatment targeting its primary mechanism has been defined. The present review critically summarizes the current knowledge in portal hypertension therapeutics, focusing on those strategies driven by the disease pathophysiology and underlying cellular mechanisms.

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Section: Lifestyle and Dietary Interventionsmentioning

confidence: 99%

Advances in therapeutic options for portal hypertension

Vilaseca

Guixé‐Muntet

Fernández‐Iglesias

et al. 2018

Therap Adv Gastroenterol

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“…66 This study is in contrast to all other studies on whole CC or DC and fibrosis that did not find a direct toxic effect. [68][69][70][71][72][73][74][75][76] Many studies found comparable effects of CC and DC on fibrosis in presence of various exogenous toxins. 71,74,75 This hepatoprotective effect included increased glu-tathione levels, reduced fibrosis on histology, decreased hydroxyproline levels (a proxy of total collagen content), reduced protein expression of αSMA, and lowered mRNA expression of TGFβ.…”

Section: Fibrosismentioning

confidence: 99%

“…In addition, these studies showed that both CC and DC reduced lipid peroxidation (as assessed by MDA) and inflammation (i.e., reduced IL 1 and 10, inducible nitric oxidase synthase, and TNFα). Only two studies found a more pronounced effect of CC than of DC 74,76 on fibrosis, specifically they found attenuated matrix metalloproteinases 2 (MMP; involved in degradation of extracellular matrix), upon TAA administration in the CCtreated arm. 74 In addition, four studies on instant CC, ground CC, or coffee extract demonstrated similar results via similar pathways, that is (I) increased glutathione; (II) decreased collagen content assessed by hydroxyproline, histology, or collagen and αSMA expression; and (III) decreased lipid peroxidation assessed by MDA or thiobarbituric acid reactive substances.…”

Section: Fibrosismentioning

confidence: 99%

Potential Mechanisms Underlying the Role of Coffee in Liver Health

2018

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Coffee, the most consumed hot beverage worldwide, is composed of many substances, of which polyphenols, caffeine, and diterpenoids are well studied. Evidence on potential effects of coffee on human health has been accumulating over the past decades. Specifically, coffee has been postulated to be hepatoprotective in several epidemiological and clinical studies. Several underlying molecular mechanisms as to why coffee influences liver health have been proposed. In this review, the authors summarized the evidence on potential mechanisms by which coffee affects liver steatosis, fibrosis, and hepatic carcinogenesis. The experimental models reviewed almost unanimously supported the theorem that coffee indeed may benefit the liver. Either whole coffee or its specific compounds appeared to decrease fatty acid synthesis (involved in steatogenesis), hepatic stellate activation (involved in fibrogenesis), and hepatic inflammation. Moreover, coffee was found to induce apoptosis and increased hepatic antioxidant capacity, which are involved in carcinogenesis.

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“…Likewise, we demonstrate that the alkaloid caffeine is present in higher levels in dGTE2 than dGTE1. Previous studies indicate that caffeine ($8 mgÁml À1 ) can induce cytotoxicity in human hepatocarcinoma cells (Romualdo et al 2020) whilst in vivo studies suggest that caffeine consumption can reduce oxidative stress and fibrosis in settings of liver disease such as cirrhosis (Amer et al 2017;Arauz et al 2017). Given this controversy regarding hepatic response to caffeine exposure, and that dGTE1 and dGTE2 are labeled as decaffeinated, it is unlikely that caffeine is responsible for the biological effects of GTE observed however further investigation is needed to establish the levels of caffeine in each extract.…”

Section: Discussionmentioning

confidence: 99%

Investigating the Opposing Effect of Two Different Green Tea Supplements on Oxidative Stress, Mitochondrial Function and Cell Viability in HepG2 Cells

Shil

Davies

Gautam

et al. 2021

Journal of Dietary Supplements

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Green tea extract (GTE) improves exercise outcomes and reduces obesity. However, case studies indicate contradictory physiology regarding liver function and toxicity. We studied the effect of two different decaffeinated GTE (dGTE) products, from a non-commercial (dGTE1) and commercial (dGTE2) supplier, on hepatocyte function using the human cell model, HepG2. dGTE1 was protective against hydrogen peroxide (H 2 O 2)-induced apoptosis and cell death by attenuating oxidative stress pathways. Conversely, dGTE2 increased cellular and mitochondrial oxidative stress and apoptosis. A bioavailability study with dGTE showed the major catechin in GTE, EGCG, reached 0.263 mgÁml À1. In vitro, at this concentration, EGCG mimicked the protective effect of dGTE1. GC/MS analysis identified steric acid and higher levels of palmitic acid in dGTE2 versus dGTE1 supplements. We demonstrate the significant biological differences between two GTE supplements which may have potential implications for manufacturers and consumers to be aware of the biological effects of supplementation.

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Coffee consumption prevents fibrosis in a rat model that mimics secondary biliary cirrhosis in humans

Cited by 21 publications

References 37 publications

Advances in therapeutic options for portal hypertension

Advances in therapeutic options for portal hypertension

Potential Mechanisms Underlying the Role of Coffee in Liver Health

Investigating the Opposing Effect of Two Different Green Tea Supplements on Oxidative Stress, Mitochondrial Function and Cell Viability in HepG2 Cells

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