Coffee consumption is inversely associated with type 2 diabetes in Chinese

Lin, Wen Yuan; Pi-Sunyer, F X; Chen, Ching Chu; Davidson, Lance E.; Liu, Chiu Shong; Li, Tsai‐Chung; Wu, Mei Fong; Li, Chia Ing; Chen, Walter; Lin, Cheng Chieh

doi:10.1111/j.1365-2362.2010.02455.x

Cited by 36 publications

(29 citation statements)

References 28 publications

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“…Coffee holds second position in consumption among all non-alcoholic beverages after water, and people from all over the world consume approximately 500 million cups of coffee every year [37]. An inverse relation between coffee and type 2 diabetes has been reported [1], [2], [3], [4], [5], [6] and it could not be explicated by caffeine, magnesium, and blood pressure [38]. Previous studies of CGA, the second abundant component in coffee after caffeine, showed its ability to delay intestinal glucose absorption and inhibit hepatic glucose output [15], [16], [17], [21].…”

Section: Discussionmentioning

confidence: 99%

“…Regular consumption of coffee has been associated with a lower risk of Type 2 diabetes mellitus and it has been replicated across sexes, geographical locations and obesity levels [1], [2], [3], [4], [5], [6]. However, Battram et al (2006) showed that the area under the curve (AUC) of glucose was significantly lowered during an oral glucose tolerance test (OGTT) following consumption of decaffeinated coffee compared with caffeinated coffee and a placebo [7].…”

Section: Introductionmentioning

confidence: 99%

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Chlorogenic Acid Stimulates Glucose Transport in Skeletal Muscle via AMPK Activation: A Contributor to the Beneficial Effects of Coffee on Diabetes

Hsu²,

2012

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Chlorogenic acid (CGA) has been shown to delay intestinal glucose absorption and inhibit gluconeogenesis. Our aim was to investigate the role of CGA in the regulation of glucose transport in skeletal muscle isolated from db/db mice and L6 skeletal muscle cells. Oral glucose tolerance test was performed on db/db mice treated with CGA and soleus muscle was isolated for 2-deoxyglucose transport study. 2DG transport was also examined in L6 myotubes with or without inhibitors such as wortmannin or compound c. AMPK was knocked down with AMPKα1/2 siRNA to study its effect on CGA-stimulated glucose transport. GLUT 4 translocation, phosphorylation of AMPK and Akt, AMPK activity, and association of IRS-1 and PI3K were investigated in the presence of CGA. In db/db mice, a significant decrease in fasting blood sugar was observed 10 minutes after the intraperitoneal administration of 250 mg/kg CGA and the effect persisted for another 30 minutes after the glucose challenge. Besides, CGA stimulated and enhanced both basal and insulin-mediated 2DG transports in soleus muscle. In L6 myotubes, CGA caused a dose- and time-dependent increase in glucose transport. Compound c and AMPKα1/2 siRNA abrogated the CGA-stimulated glucose transport. Consistent with these results, CGA was found to phosphorylate AMPK and ACC, consistent with the result of increased AMPK activities. CGA did not appear to enhance association of IRS-1 with p85. However, we observed activation of Akt by CGA. These parallel activations in turn increased translocation of GLUT 4 to plasma membrane. At 2 mmol/l, CGA did not cause any significant changes in viability or proliferation of L6 myotubes. Our data demonstrated for the first time that CGA stimulates glucose transport in skeletal muscle via the activation of AMPK. It appears that CGA may contribute to the beneficial effects of coffee on Type 2 diabetes mellitus.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Chlorogenic Acid Stimulates Glucose Transport in Skeletal Muscle via AMPK Activation: A Contributor to the Beneficial Effects of Coffee on Diabetes

Hsu²,

2012

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“…Conversely, moderate alcohol 56,57 and coffee consumption 58–60 may prevent the development of both NAFLD and T2D. These findings, however, do not translate into specific lifestyle suggestions so far.…”

Section: From Fatty Liver To Diabetesmentioning

confidence: 93%

“…[47][48][49][50][51] Smoking favors hepatic lipogenesis and fibrotic progression in NAFLD [52][53][54] as well as the development of T2D. 55 Conversely, moderate alcohol 56,57 and coffee consumption [58][59][60] may prevent the development of both NAFLD and T2D. These findings, however, do not translate into specific lifestyle suggestions so far.…”

Section: Hepatocyte Ir: Molecular Insights Into the Initiator Of Systmentioning

confidence: 99%

Liver and diabetes. A vicious circle

Loria

Lonardo

Anania

2013

Hepatology Research

183

123

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The complex and bi-directional relationship linking the liver and diabetes has recently gained intense new interest. This critical review of the published work aims to highlight the most recent basic and clinical data underlying the development of type 2 diabetes, in those with non-alcoholic fatty liver disease. Moreover, the potentially detrimental effects of type 2 diabetes in liver injury are also discussed in each of the two sections of the present paper. Fatty liver and diabetes share insulin resistance as their chief pathogenic determinant. The roles of the hypothalamus, the intestinal microbiome, white adipose tissue and inflammation are discussed in detail. Molecular insights into hepatocyte insulin resistance as the initiator of systemic insulin resistance are also presented with full coverage of the danger of fatty acids. Lipotoxicity, apoptosis, lipoautophagy, endoplasmic reticular stress response and recent developments in genetics are discussed. Closing the circle, special emphasis is given to biochemical pathways and clinical evidence supporting the role of type 2 diabetes as a risk factor for the development of progressive liver disease, including non-alcoholic steatohepatitis, cirrhosis and primary liver cancer. In conclusion, data support non-alcoholic fatty liver disease as a risk factor for the development of type 2 diabetes which is, in turn, a major contributor to progressive liver disease. This pathway leading from fatty liver to type 2 diabetes and back from the latter to the progressive liver disease is a vicious circle.

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“…Tea consumption was similar across the groups but coffee consumption in the ‘high-risk' cluster was reported less often than the ‘low-risk' cluster or NGT. These findings are interesting in view of the accumulating epidemiological evidence suggesting that physical activity, 27 coffee drinking 28, 29, 30 and alcohol consumption 31, 32 protect against type 2 diabetes.…”

Section: Discussionmentioning

confidence: 73%

A simple scoring method using cardiometabolic risk measurements in pregnancy to determine 10-year risk of type 2 diabetes in women with gestational diabetes

et al. 2013

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Objective:To examine if clustering of cardiometabolic risk factors in pregnancy predicts type 2 diabetes and cardiovascular disease (CVD) risk at 10 years in women with gestational diabetes mellitus (GDM).Study design and subjects:A prospective case–control study in 150 GDM and 72 overweight women with normal glucose tolerance (NGT) measured cardiometabolic risk factors (body mass index (BMI), systolic blood pressure (SBP), fasting glucose, insulin, and triglycerides and high-density lipoprotein (HDL) cholesterol) at 28 weeks gestation and 6 months and 10 years after pregnancy. Cluster analysis of cardiometabolic risk factors in pregnancy was used to stratify GDM as ‘high' and ‘low risk' for diabetes and CVD risk at 10 years. The data in pregnancy were used to determine a simple method for assessing risk of future diabetes.Results:BMI in the 150 GDM at study entry was similar to NGT, but 35% of GDM fell into a ‘high-risk cluster' with elevated BMI, SBP, glucose, insulin and triglycerides and lower HDL levels. At 10 years, type 2 diabetes was sixfold higher in ‘high-risk' GDM (odds ratio (OR)=6.75, confidence interval (CI)=2.0, 22.7, P=0.002) compared with ‘low-risk' GDM and was not reported in NGT. The ‘high-risk' cluster predicted type 2 diabetes better than BMI>30 (OR=2.13, CI=0.71, 6.4, P=0.179) or fasting glucose >5.5 mmol l–1, (OR=4.56, CI=1.50, 13.85, P=0.007). We determined that GDM with any four of the cardiometabolic risk factors (BMI>30 kg m–2, fasting glucose>5.0 mmol l–1, insulin>7.8 mU l–1, triglycerides >2.4 mmol l–1, HDL<1.6 mmol l–1 or SBP>105 mm Hg) in pregnancy would be in a ‘high-risk' cluster.Conclusions:A metabolic syndrome-like cluster in pregnant GDM identifies risk for type 2 diabetes providing an opportunity to focus on rigorous lifestyle interventions after delivery to reduce the burden of disease attributed to this condition.

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Coffee consumption is inversely associated with type 2 diabetes in Chinese

Abstract: Background-Coffee consumption has been shown to be inversely associated to type 2 diabetes mellitus (T2DM), but evidence in Chinese populations is limited. We investigated the relationship between coffee consumption and T2DM in a population-based cohort of middle-aged Chinese.

Cited by 36 publications

References 28 publications

Chlorogenic Acid Stimulates Glucose Transport in Skeletal Muscle via AMPK Activation: A Contributor to the Beneficial Effects of Coffee on Diabetes

Chlorogenic Acid Stimulates Glucose Transport in Skeletal Muscle via AMPK Activation: A Contributor to the Beneficial Effects of Coffee on Diabetes

Liver and diabetes. A vicious circle

A simple scoring method using cardiometabolic risk measurements in pregnancy to determine 10-year risk of type 2 diabetes in women with gestational diabetes

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