Coffee consumption is associated with a decreased risk of incident chronic kidney disease

Abstract

Background: Recent studies have suggested a renal protective effect of coffee consumption against development of chronic kidney disease (CKD), although the results remain inconclusive. We performed a protocol for systematic review and meta-analysis to comprehensively investigate this association by summarizing all available data. Methods: An all-round retrieval will be performed in 5 electronic journal databases from their inception to June 2021, which comprise Medline, PubMed, Embase, ScienceDirect, and the Cochrane Library. The following key words were used on combination with Boolean operators AND or OR: “coffee,” “caffeine,” “renal insufficiency,” “chronic kidney diseases,” “chronic renal diseases.” Two authors completed the quality assessment using the Newcastle–Ottawa Scale for observational studies. The meta-analysis was conducted using Review Manager 5.3 software from the Cochrane Collaboration (London, UK). Results: The findings of this study will be submitted to peer-reviewed journals for publication. Conclusion: Coffee consumption may be associated with a lower risk of incident CKD.

Caffeine causes cell cycle arrest at G0/G1 and increases of ubiquitinated proteins, ATP and mitochondrial membrane potential in renal cells

“…Recent systematic review and meta-analysis of clinical studies have revealed that coffee intake is associated with the lower incidence of CKD in a dose-dependent manner [8] . The association between coffee consumption and lower risk of CKD is also supported by other two studies [9] , [10] . In the context of kidney stone disease (nephrolithiasis), several lines of recent evidence have consistently shown the protective roles of caffeine against nephrolithiasis [11] , [12] , [13] , [14] , [15] .…”

Metabolic profiling identifies the significance of caffeine metabolism in CKD

“…Previous studies have found that coffee consumption may reduce the risk of CKD (Li et al, 2021), showing a negative association between caffeine intake and all-cause mortality in patients with CKD (Bigotte et al, 2019). However, other studies have shown that caffeine exacerbates hypertension in rats with polycystic kidney disease (Tanner and Tanner, 2001), potentiates the development of more severe tubulointerstitial changes, and increases focal glomerulosclerosis (Tofovic et al, 2002).…”

The Epigenetic Effects of Coffee

“…In a systematic review and meta-analysis study, it was shown that a higher CAF intake may be associated with a lower risk of kidney stones [ 62 ]. In another systematic review and meta-analysis, it was revealed that coffee consumption may be associated with a lower risk of chronic kidney disease (CKD) [ 63 ]. In 2022, a meta-analysis of the published cohort evidence was suggestive of an inverse association between coffee consumption and renal cancer risk [ 64 ].…”