Coffee consumption attenuates short-term fructose-induced liver insulin resistance in healthy men

Lecoultre, Virgile; Carrel, Guillaume; Egli, Léonie; Binnert, Christophe; Boss, Andreas; MacMillan, Erin L.; Kreis, Roland; Boesch, Chris; Darimont, Christian; Tappy, Luc

doi:10.3945/ajcn.113.069526

Cited by 81 publications

(50 citation statements)

References 51 publications

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“…Compelling evidence from epidemiologic studies has consistently linked coffee consumption with improved insulin sensitivity and glucose metabolism and a decreased risk of type 2 diabetes (19)(20)(21)(22). Our findings, which showed that genetically determined high habitual coffee consumption interacted with weight-loss dietary interventions on glycemic changes, lent further support to the relation between coffee consumption and glucose metabolism (9).…”

Section: Discussionsupporting

confidence: 69%

Genetic variation of habitual coffee consumption and glycemic changes in response to weight-loss diet intervention: the Preventing Overweight Using Novel Dietary Strategies (POUNDS LOST) trial

Han

Sun

et al. 2017

The American Journal of Clinical Nutrition

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Background: Coffee consumption has been associated with glucose metabolism and risk of type 2 diabetes. Objective: We examined whether the genetic variation determining habitual coffee consumption affected glycemic changes in response to weight-loss dietary intervention. Design: A genetic risk score (GRS) was calculated based on 8 habitual coffee consumption-associated single nucleotide polymorphisms. We used general linear models to test changes in glycemic traits in groups randomly assigned to high-and low-fat diets according to tertiles of the GRS. Results: We observed significant interactions between the GRS and low compared with high dietary fat intake on 6-mo changes in fasting insulin and homeostasis model assessment of insulin resistance (HOMA-IR) (P-interaction = 0.023 and 0.022, respectively), adjusting for age, sex, race, physical activity, smoking, alcohol, seasonal variation, and baseline values of the respective outcomes. Participants with a higher GRS of habitual coffee consumption showed a greater reduction in fasting insulin and a marginally greater decrease in HOMA-IR in the low-fat diet intervention group. Conclusions: Our data suggest that participants with genetically determined high coffee consumption may benefit more by eating a low-fat diet in improving fasting insulin and HOMA-IR in a short term. This trial was registered at clinicaltrials.gov as NCT00072995 and NCT03258203.Am J Clin Nutr 2017;106:1321-6.

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Section: Discussionsupporting

confidence: 69%

Genetic variation of habitual coffee consumption and glycemic changes in response to weight-loss diet intervention: the Preventing Overweight Using Novel Dietary Strategies (POUNDS LOST) trial

Han

Sun

et al. 2017

The American Journal of Clinical Nutrition

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“…Effect of increased or reduced added sugar intake on fat depots Table 2 13,31-36 summarizes the results from 7 randomized controlled intervention trials: 6 in adults 13,[31][32][33][34][35] and 1 in children. 36 The 6 studies in adults were designed to compare sugar intake as part of a hypercaloric diet with intake of a eucaloric control diet that Full text articles excluded because 1) not relevant to study objective; 2) using same study sample (in this case, only one study was included in the present review); 3) single arm trial; 4) observational studies (no prospective): n=27 contained no excess sugars.…”

Section: Resultsmentioning

confidence: 99%

“…In 4 trials, fructose or glucose or both were added to a weight-maintaining diet to create a hypercaloric diet that was then compared with a weight-maintaining diet alone. [32][33][34][35] In these 4 trials, fructose or glucose or both provided calories !35% of the energy requirement.…”

Section: Resultsmentioning

confidence: 99%

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Potential link between excess added sugar intake and ectopic fat: a systematic review of randomized controlled trials

Karlsen

Chung

et al. 2015

Nutr Rev

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Context: The effect of added sugar intake on ectopic fat accumulation is a subject of debate. Objective: A systematic review and meta-analysis of randomized controlled trials (RCTs) was conducted to examine the potential effect of added sugar intake on ectopic fat depots. Data Sources: MEDLINE, CAB Abstracts, CAB Global Health, and EBM (Evidence-Based Medicine) Reviews -Cochrane Central Register of Controlled Trials databases were searched for studies published from 1973 to September 2014. Data Extraction: RCTs with a minimum of 6 days' duration of added sugar exposure in the intervention group were selected. The dosage of added sugar intake as a percentage of total energy was extracted or calculated. Means and standard deviations of pre-and post-test measurements or changes in ectopic fat depots were collected. Data Synthesis: Fourteen RCTs were included. Most of the studies had a medium to high risk of bias. Meta-analysis showed that, compared with eucaloric controls, subjects who consumed added sugar under hypercaloric conditions likely increased ectopic fat, particularly in the liver (pooled standardized mean difference ¼ 0.9 [95%CI, 0.6-1.2], n ¼ 6) and muscles (pooled SMD ¼ 0.6 [95%CI, 0.2-1.0], n ¼ 4). No significant difference was observed in liver fat, visceral adipose tissue, or muscle fat when isocaloric intakes of different sources of added sugars were compared. Conclusions: Data from a limited number of RCTs suggest that excess added sugar intake under hypercaloric diet conditions likely increases ectopic fat depots, particularly in the liver and in muscle fat. There are insufficient data to compare the effect of different sources of added sugars on ectopic fat deposition or to compare intake of added sugar with intakes of other macronutrients. Future well-designed RCTs with sufficient power and duration are needed to address the role of sugars on ectopic fat deposition.

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“…A growing number of epidemiologic evidence has shown an inverse association between coffee consumption and the risk of NAFLD (16). Coffee consumption has also been associated with reduced levels of hepatic aminotransferases and progression of pre-existing liver disease (17,18). Besides, experimental studies have demonstrated that coffee and coffee polyphenols improved insulin sensitivity, fatty liver, and abdominal fat (16).…”

Section: Introductionmentioning

confidence: 99%

Effects of Green Coffee Bean Extract Supplementation on Patients with Non-Alcoholic Fatty Liver Disease: A Randomized Clinical Trial

et al. 2017

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Background: Non-alcoholic fatty liver disease (NAFLD) is a major worldwide public health problem with no effective treatment options. Green coffee bean extract (GCBE) is a rich source of bioactive phytochemicals with a variety of biochemical and physiological effects. Objectives: The aim of this study was to investigate the effects of GCBE on the management of patients with NAFLD. Methods: 44 patients with NAFLD were enrolled in a parallel, double-blind, placebo-controlled clinical trial. The participants were administered either GCBE or placebo (1 gram/day) for 8 weeks. They also were advised to follow a standard energy-balanced diet and physical activity. Liver ultrasonography, anthropometric variables, and biochemical parameters were compared at pre-and post-intervention.

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Coffee consumption attenuates short-term fructose-induced liver insulin resistance in healthy men

Abstract: Coffee consumption attenuates hepatic insulin resistance but not the increase of IHCLs induced by fructose overfeeding. This effect does not appear to be mediated by differences in the caffeine or chlorogenic acid content. This trial was registered at clinicaltrials.gov as NCT00827450.

Cited by 81 publications

References 51 publications

Genetic variation of habitual coffee consumption and glycemic changes in response to weight-loss diet intervention: the Preventing Overweight Using Novel Dietary Strategies (POUNDS LOST) trial

Genetic variation of habitual coffee consumption and glycemic changes in response to weight-loss diet intervention: the Preventing Overweight Using Novel Dietary Strategies (POUNDS LOST) trial

Potential link between excess added sugar intake and ectopic fat: a systematic review of randomized controlled trials

Effects of Green Coffee Bean Extract Supplementation on Patients with Non-Alcoholic Fatty Liver Disease: A Randomized Clinical Trial

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