Coffee Consumption and Whole-Blood Gene Expression in the Norwegian Women and Cancer Post-Genome Cohort

Abstract

Norwegians are the second highest consumers of coffee in the world. Lately, several studies have suggested that beneficial health effects are associated with coffee consumption. By analyzing whole-blood derived, microarray based mRNA gene expression data from 958 cancer-free women from the Norwegian Women and Cancer Post-Genome Cohort, we assessed the potential associations between coffee consumption and gene expression profiles and elucidated functional interpretation. Of the 958 women included, 132 were considered low coffee consumers (<1 cup of coffee/day), 422 moderate coffee consumers (1–3 cups of coffee/day), and 404 were high coffee consumers (>3 cups of coffee/day). At a false discovery rate <0.05, 139 genes were differentially expressed between high and low consumers of coffee. A subgroup of 298 nonsmoking, low tea consumers was established to isolate the effects of coffee from smoking and potential caffeine containing tea consumption. In this subgroup, 297 genes were found to be differentially expressed between high and low coffee consumers. Results indicate differentially expressed genes between high and low consumers of coffee with functional interpretations pointing towards a possible influence on metabolic pathways and inflammation.

Chronic voluntary caffeine intake in male Wistar rats reveals individual differences in addiction-like behavior

“…The medium preference group exhibited a modest decrease in caffeine preference from the continuous access period to the intermittent access period. In humans, similar populations of caffeine drinkers have been distinguished (Goncalves et al, 2017;Barnung et al, 2018;Mitchell et al, 2014;Kuang et al, 2018;Cornelis, 2019). Interestingly, the amount of caffeine that was consumed in the different preference groups in the present study were similar to amounts of caffeine that are consumed in different groups of humans who drink caffeinated beverages.…”

The Impact of Coffee and Its Selected Bioactive Compounds on the Development and Progression of Colorectal Cancer In Vivo and In Vitro

“…On the other hand, systematic review by Paiva et al showed the absence of changes in C-reactive protein concentration after coffee consumption and decreased concentration after caffeine intake [17]. Changes in the expression of genes, especially those involved in inflammation in human, animal, and in vitro models [18,19,20], were reported. According to one of the animal studies, bean roasting affected the anti-inflammatory and antioxidant properties of coffee [21].…”

The Impact of Caffeine and Coffee on Human Health

“…The impact of coffee intake on gene expression and the lipidome were investigated by Barnung et al [ 16 ] and Kuang et al [ 17 ], respectively. Barnung et al [ 16 ] reported on the results from a population-based whole-blood gene expression analysis of coffee consumption that pointed to metabolic, immune, and inflammation pathways. Using samples from a controlled trial of coffee intake, Kuang et al [ 17 ] reported that coffee intake led to lower levels of specific lysophosphatidylcholines.…”