Coffee consumption and the risk of latent autoimmune diabetes in adults—results from a Swedish case–control study

Löfvenborg, Josefin E.; Andersson, Tomas; Carlsson, Per‐Ola; Dorkhan, Mozhgan; Groop, Leif; Martinell, Mats; Rasouli, Bahareh; Storm, Petter; Tuomi, Tiinamaija; Carlsson, Sofia

doi:10.1111/dme.12469

Cited by 19 publications

(34 citation statements)

References 31 publications

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“…The suggested positive association between artificially sweetened beverages and diabetes risk remains to be further explored. This study supports the notion that dietary factors may influence LADA development (21,40,41). This is important as the identification of modifiable risk factors could aid in preventing autoimmune diabetes.…”

Section: Discussionsupporting

confidence: 85%

“…1, see section on supplementary data given at the end of this article) (21). ESTRID is a sub-study to ANDIS (All New Diabetics in Scania; http://andis.ludc.med.lu.se), which is a large study aiming to characterize all new diabetes cases within the county of Scania (southern Sweden, 1.3 million inhabitants) with regard to diabetes type, clinical features and genotype.…”

Section: Study Population and Designmentioning

confidence: 99%

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Sweetened beverage intake and risk of latent autoimmune diabetes in adults (LADA) and type 2 diabetes

Löfvenborg

Andersson

Carlsson

et al. 2016

European Journal of Endocrinology

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Objective: Sweetened beverage intake is associated with increased risk of type 2 diabetes, but its association with autoimmune diabetes is unclear. We aimed to investigate sweetened beverage intake and risk of latent autoimmune diabetes in adults (LADA); autoimmune diabetes with features of type 2 diabetes. Design/methods: Data from a Swedish population-based study was used, including incident cases of LADA (n = 357) and type 2 diabetes (n = 1136) and randomly selected controls (n = 1371). Diabetes classification was based on onset age (≥35), glutamic acid decarboxylase autoantibodies (GADA) and C-peptide. Sweetened beverage intake information was derived from a validated food frequency questionnaire. ORs adjusted for age, sex, family history of diabetes, education, lifestyle, diet, energy intake and BMI were estimated using logistic regression. Results: Daily intake of >2 servings of sweetened beverages (consumed by 6% of participants) was associated with increased risk of LADA (OR: 1.99, 95% CI: 1.11-3.56), and for each 200 mL daily serving, OR was 1.15 (95% CI: 1.02-1.29). Findings were similar for sugar-sweetened (OR: 1.18, 95% CI: 1.00-1.39) and artificially sweetened beverages (OR: 1.12, 95% CI: 0.95-1.32). Similarly, each daily serving increment in total sweetened beverage conferred 20% higher type 2 diabetes risk (95% CI: 1.07-1.34). In type 2 diabetes patients, high consumers displayed higher HOMA-IR levels (4.5 vs 3.5, P = 0.0002), but lower HOMA-B levels (55 vs 70, P = 0.0378) than non-consumers. Similar tendencies were seen in LADA. Conclusions: High intake of sweetened beverages was associated with increased risk of LADA. The observed relationship resembled that with type 2 diabetes, suggesting common pathways possibly involving insulin resistance.

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Section: Discussionsupporting

confidence: 85%

Section: Study Population and Designmentioning

confidence: 99%

Sweetened beverage intake and risk of latent autoimmune diabetes in adults (LADA) and type 2 diabetes

Löfvenborg

Andersson

Carlsson

et al. 2016

European Journal of Endocrinology

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show abstract

“…The details of ESTRID have been described previously [14]. In short, ESTRID was initiated in 2010, recruiting incident cases of diabetes through diabetes registries in the Swedish counties of Skåne (All New Diabetics in Skåne [ANDIS], http://andis.…”

Section: Methodsmentioning

confidence: 99%

Low birthweight is associated with an increased risk of LADA and type 2 diabetes: results from a Swedish case–control study

et al. 2015

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Aims/hypothesis Our aim was to investigate the association between birthweight and latent autoimmune diabetes in adults (LADA), a common diabetes form with features of both type 1 and type 2 diabetes. OR 39.93 (19.27, 82.71). Family history of diabetes had little impact on these estimates. Conclusions/interpretation Our results suggest that low birthweight may be a risk factor for LADA of the same strength as for type 2 diabetes. These findings support LADA, despite its autoimmune component, having an aetiology that includes factors related to type 2 diabetes.

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“…The ESTRID data collection has been described in detail elsewhere. 15 In short, incident cases of diabetes were identified continuously using two population-based diabetes registries in Sweden (ANDIS; All New Diabetics in Scania http://andis.ludc.med.lu.se/, and ANDiU; All New Diabetics in Uppsala http://www.andiu.se/), aimed at characterizing all new diabetes cases with regard to clinical and genetic factors. To ESTRID we invited all new cases of LADA identified in Skåne (from 2010 onwards) and Uppsala (from 2012 onwards) together with a random sample of patients with newly diagnosed type 2 diabetes (four per LADA case).…”

Section: Methodsmentioning

confidence: 99%

Fatty fish consumption and risk of latent autoimmune diabetes in adults

et al. 2014

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Objective:It has been suggested that intake of fatty fish may protect against both type 1 and type 2 diabetes. Hypotheses rest on the high marine omega-3 fatty acid eicosapentaenoic acid+docosahexaenoic acid (EPA+DHA) and vitamin D contents, with possible beneficial effects on immune function and glucose metabolism. Our aim was to investigate, for the first time, fatty fish consumption in relation to the risk of latent autoimmune diabetes in adults (LADA).Methods:Analyses were based on data from a Swedish case–control study with incident cases of LADA (n=89) and type 2 diabetes (n=462) and randomly selected diabetes-free controls (n=1007). Diabetes classification was based on the onset of age (⩾35), glutamic acid decarboxylase autoantibodies, and C-peptide. A validated food frequency questionnaire was used to derive information on previous intake of fish, polyunsaturated long-chain omega-3 fatty acids (n-3 PUFA) and supplementation of fish oil and vitamin D. Odds ratios (ORs) with 95% confidence intervals (CIs) were calculated using logistic regression, adjusted for age, gender, body mass index (BMI), family history of diabetes, physical activity, smoking, education, and consumption of alcohol, fruit, vegetables and red meat.Results:Weekly fatty fish consumption (⩾1 vs <1 serving per week), was associated with a reduced risk of LADA but not type 2 diabetes (OR 0.51, 95% CI 0.30–0.87, and 1.01, 95% CI 0.74–1.39, respectively). Similar associations were seen for estimated intake of n-3 PUFA (⩾0.3 g per day; LADA: OR 0.60, 95% CI 0.35–1.03, type 2 diabetes: OR 1.14, 95% CI 0.79–1.58) and fish oil supplementation (LADA: OR 0.47, 95% CI 0.19–1.12, type 2 diabetes: OR 1.58, 95% CI 1.08–2.31).Conclusions:Our findings suggest that fatty fish consumption may reduce the risk of LADA, possibly through effects of marine-originated omega-3 fatty acids.

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Coffee consumption and the risk of latent autoimmune diabetes in adults—results from a Swedish case–control study

Abstract: Our findings confirm that coffee consumption is associated with a reduced risk of Type 2 diabetes. Interestingly, the findings suggest that coffee may be associated with development of autoimmunity and possibly an increased risk of more Type 1-like latent autoimmune diabetes in adults.

Cited by 19 publications

References 31 publications

Sweetened beverage intake and risk of latent autoimmune diabetes in adults (LADA) and type 2 diabetes

Sweetened beverage intake and risk of latent autoimmune diabetes in adults (LADA) and type 2 diabetes

Low birthweight is associated with an increased risk of LADA and type 2 diabetes: results from a Swedish case–control study

Fatty fish consumption and risk of latent autoimmune diabetes in adults

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