Coffee consumption and seizure frequency in patients with drug-resistant focal epilepsy

Bourgeois-Vionnet, Julie; Ryvlin, Philippe; Elsensohn, Mad-Hélénie; Michel, Véronique; Valton, Luc; Derambure, Philippe; Frazzini, Valério; Hirsch, Édouard; Maillard, Louis; Bartolomei, Fabricē; Biberon, Julien; Petit, Jérôme; Biraben, Arnaud; Crespel, Arielle; Thomas, Pierre; Lemesle-Martin, Martine; Convers, Philippe; Leclercq, M.; Boulogne, Sébastien; Roy, Pascal; Rheims, Sylvain

doi:10.1016/j.yebeh.2021.108486

Cited by 7 publications

(6 citation statements)

References 30 publications

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“…Having stimulant drinks, such as common coffee, after COVID‐19 vaccination was another reported seizure precipitant in PwE 34 . In this sense, previous evidence supports the effect of caffeine intake on seizure control in PwE 49 . Stress and fatigue have also been reported as seizure precipitants following COVID‐19 vaccination 30,34 .…”

Section: Discussionmentioning

confidence: 74%

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Association of seizure with COVID‐19 vaccines in persons with epilepsy: A systematic review and meta‐analysis

Rafati,

Jameie,

Amanollahi

et al. 2023

Journal of Medical Virology

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Seizure aggravation following coronavirus disease 2019 (COVID‐19) vaccines is a major cause behind vaccine hesitancy among persons with epilepsy (PwE), resulting in lower immunization rates. We systematically reviewed seizure‐activity‐related events in PwE following COVID‐19 vaccination. We systematically searched PubMed, Web of Science, Scopus, and Cochrane Library, until January 31, 2023, and included articles reporting seizure activity‐related events in PwE receiving COVID‐19 vaccination. The Preferred Reporting Items for Systematic Reviews and Meta‐Analyses were followed. The protocol was registered with PROSPERO (CRD42022312475). Outcomes included pooled incidence proportions of (a) increased seizure frequency, (b) status epilepticus (SE), and (c) change in seizure type. Of the 2207 studies, 16 entered the meta‐analysis. The pooled incidence proportion of increased seizure frequency (16 studies‐3245 PwE) was 5% (95% CI: 3%−7%, I2 = 52%). Regarding increased seizure frequency, no significant difference was observed between mRNA and viral vector (OR: 1.11, 95% CI: 0.49−2.52, I2 = 0%), and between mRNA and inactivated virus (OR: 1.60, 95% CI: 0.27−9.37; I2 = 0%). The pooled incidence proportion of SE (15 studies‐2387 PwE) was 0.08% (95% CI: 0.02%−0.33%, I2 = 0%). Ultimately, the pooled incidence proportion of change in seizure type (7 studies‐1172 PwE) was 1% (95% CI: 1%−2%, I2 = 0%). The meta‐analysis revealed post‐COVID‐19‐vaccination increased seizure frequency in 5% of PwE, with no difference between mRNA and viral vector or inactivated virus vaccines. Furthermore, we found 0.08% and 1% incidence proportions for postvaccination SE and change in seizure type, respectively. While noteworthy, these values are far less than reports for COVID‐19 infection, emphasizing vaccination importance in preventing COVID‐19 consequences in PwE.

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Section: Discussionmentioning

confidence: 74%

“…34 In this sense, previous evidence supports the effect of caffeine intake on seizure control in PwE. 49 Stress and fatigue have also been reported as seizure precipitants following COVID-19 vaccination. 30,34 These results corroborate previous vaccine safety research among PwE.…”

Section: Other Possible Related Factorsmentioning

confidence: 84%

Association of seizure with COVID‐19 vaccines in persons with epilepsy: A systematic review and meta‐analysis

Rafati,

Jameie,

Amanollahi

et al. 2023

Journal of Medical Virology

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“…Even the moderate consumption of coffee had a beneficial effect on the occurrence of focal bilateral clonic-tonic seizures. However, in the same study, the high intake of caffeine favored this seizure type [35]. Nonetheless, considering all types of seizures, these authors did not find any deleterious influence of trimethylxanthine on seizure frequency [35].…”

Section: Discussionmentioning

confidence: 74%

“…There was no association with the risk of seizure or epilepsy (N = 246) and caffeine intake which was comparable for the total cohort [34]. A detailed analysis of the influence of coffee consumption on seizure frequency in 619 patients with drug-resistant focal epilepsy was carried out by Bourgeois-Vionnet [35]. Coffee intake was classified into four groups: no consumption, rare (<1 cup weekly-3 cups weekly), moderate (4 cups weekly-3 cups daily), and high (>4 cups daily).…”

Section: Studies Showing Mainly No Association Between Dietary Caffei...mentioning

confidence: 98%

“…Strikingly, patients with moderate caffeine intake had a lower number of focal bilateral clonic-tonic seizures when compared to other groups. However, in those with high caffeine consumption (more than 4 cups of coffee daily), the trimethylxanthine favored the occurrence of focal bilateral clonic-tonic seizures [35]. The influence of caffeine on seizure frequency is depicted in Table 3.…”

Section: Studies Showing Mainly No Association Between Dietary Caffei...mentioning

confidence: 99%

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Caffeine and Its Interactions with Antiseizure Medications—Is There a Correlation between Preclinical and Clinical Data?

Miziak,

Błaszczyk,

Chrościńska-Krawczyk

et al. 2023

IJMS

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Experimental studies reveal that caffeine (trimethylxanthine) at subconvulsive doses, distinctly reduced the anticonvulsant activity of numerous antiseizure medications (ASMs) in rodents, oxcarbazepine, tiagabine and lamotrigine being the exceptions. Clinical data based on low numbers of patients support the experimental results by showing that caffeine (ingested in high quantities) may sharply increase seizure frequency, considerably reducing the quality of patients’ lives. In contrast, this obviously negative activity of caffeine was not found in clinical studies involving much higher numbers of patients. ASMs vulnerable to caffeine in experimental models of seizures encompass carbamazepine, phenobarbital, phenytoin, valproate, gabapentin, levetiracetam, pregabalin and topiramate. An inhibition of R-calcium channels by lamotrigine and oxcarbazepine may account for their resistance to the trimethylxanthine. This assumption, however, is complicated by the fact that topiramate also seems to be a blocker of R-calcium channels. A question arises why large clinical studies failed to confirm the results of experimental and case-report studies. A possibility exists that the proportion of patients taking ASMs resistant to caffeine may be significant and such patients may be sufficiently protected against the negative activity of caffeine.

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Phthalate exposure and DNA oxidative damage in young people of takeaway food lovers

Zhong

Guo

Jia

et al. 2022

Environ Sci Pollut Res

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Coffee consumption and seizure frequency in patients with drug-resistant focal epilepsy

Cited by 7 publications

References 30 publications

Association of seizure with COVID‐19 vaccines in persons with epilepsy: A systematic review and meta‐analysis

Association of seizure with COVID‐19 vaccines in persons with epilepsy: A systematic review and meta‐analysis

Caffeine and Its Interactions with Antiseizure Medications—Is There a Correlation between Preclinical and Clinical Data?

Phthalate exposure and DNA oxidative damage in young people of takeaway food lovers

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