Coffee consumption and nonalcoholic fatty liver onset: a prospective study in the general population

Zelber‐Sagi, Shira; Salomone, Federico; Webb, Muriel; Lotan, Roni; Yeshua, Hanny; Halpern, Zamir; Santo, Erwin; Oren, Ran; Shibolet, Oren

doi:10.1016/j.trsl.2014.10.008

Cited by 68 publications

(73 citation statements)

References 39 publications

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“…However, the precise pathophysiologic mechanisms that underpin this relationship remain incompletely characterized. In a recent prospective study by Zelber-Sagi and colleagues, coffee was associated only with reduced serum markers of fibrosis over time, but did not impact steatosis 20 . Further studies are needed to determine whether coffee affects steatogenesis, or rather if the hepatoprotective benefits of coffee relate primarily to prevention of fibrosis and hepatocarcinogenesis 20 .…”

Section: Discussionmentioning

confidence: 91%

Coffee consumption is not associated with prevalent subclinical cardiovascular disease (CVD) or the risk of CVD events, in nonalcoholic fatty liver disease: results from the multi-ethnic study of atherosclerosis

et al. 2017

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Background Atherosclerosis and its clinical sequelae represent the leading cause of mortality among patients with nonalcoholic fatty liver disease (NAFLD). While epidemiologic data support the hepatoprotective benefits of coffee in NAFLD, whether coffee improves NAFLD-associated CVD risk is unknown. Methods We examined 3,710 ethnically-diverse participants from the Multi-Ethnic Study of Atherosclerosis (MESA) cohort, without history of known liver disease, and with available coffee data from a validated 120-item food frequency questionnaire. All participants underwent baseline non-contrast cardiac CT from which NAFLD was defined by liver:spleen ratio (L:S<1.0), and subclinical CVD was defined by coronary artery calcium (CAC)>0. Major CVD events were defined by the first occurrence of myocardial infarction, cardiac arrest, angina, stroke, or CVD death. We used log-binomial regression to calculate the adjusted prevalence ratio (PR) for CAC>0 by coffee intake and NAFLD status, and events were compared between groups using frequency of events within adjusted Cox proportional hazard regression models. Results Seventeen percent (N=637) of participants met criteria for NAFLD. NAFLD participants were more likely to have elevated BMI (mean 31.1 ± 5.5 kg/m2 vs. 28.0 ± 5.2 kg/m2, p<0.0001), and diabetes (22% vs. 11%, p<0.0001), but did not differ in daily coffee consumption (p=0.97). Among NAFLD participants, coffee consumption was not associated with prevalent, baseline CAC>0 (PR=1.02 [0.98-1.07]). Over 12.8 years of follow-up, 93 NAFLD and 415 non-NAFLD participants experienced a CV event. However, coffee intake was not associated with incident CVD events, in either NAFLD (HR=1.05 [0.91-1.21]) or non-NAFLD participants (HR=1.03 [0.97-1.11]). Conclusion In a large, population-based cohort, coffee consumption was not associated with the prevalence of subclinical CVD, nor did coffee impact the future risk of major CVD events, regardless of underlying NAFLD status.

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Section: Discussionmentioning

confidence: 91%

Coffee consumption is not associated with prevalent subclinical cardiovascular disease (CVD) or the risk of CVD events, in nonalcoholic fatty liver disease: results from the multi-ethnic study of atherosclerosis

et al. 2017

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“…Natural phenolic compounds can promote lipolysis, inhibit lipogenesis and counteract hepatic fibrogenesis27. In a cross-sectional study, although no association was demonstrated between coffee consumption and the new onset of NAFLD, high consumption of coffee was related to a lower proportion of clinically significant fibrosis ≥ F2; part of the benefits can be attributed to caffeine content2829. Experimental studies have shown that diets enriched with omega-3 polyunsaturated fatty acid can increase insulin sensitivity in rats, reduce intrahepatic triglyceride levels and improve steatohepatitis30.…”

Section: Discussionmentioning

confidence: 99%

Long-term lifestyle interventions in middle-aged and elderly men with nonalcoholic fatty liver disease: a randomized controlled trial

Dong

Zhang

Huang

et al. 2016

Sci Rep

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Nonalcoholic fatty liver disease (NAFLD), a metabolic disorder related to insulin resistance and metabolic syndrome, has become a public health concern. Currently, the principal therapeutic modalities targeting NAFLD are lifestyle interventions. However, the efficacy of long-term lifestyle interventions in managing NAFLD remains largely unexplored. This study aimed to evaluate the efficacy of long-term lifestyle interventions in middle-aged and elderly men with NAFLD. All 280 eligible patients were randomized to the control or test group. Patients in the test group received counseling on diet and exercise from 2 physicians every 3 months via a phone call. Patients in the control group received only counseling in annual checkups without regular intervention. After the 2-year periodic intervention, body weight, abdominal circumference, ALT, TCH, LDL-C and HDL-C decreased in the test group. Specifically, the fatty liver index (FLI) and NAFLD-fibrosis score (NAFLD-FS) reduced markedly in the test group. However, in the control group, there was only a significant decrease in LDL-C, HDL-C and NAFLD-FS (P < 0.001). The liver steatosis grade of the test group decreased significantly, while it increased in the control group. In NAFLD, long-term lifestyle interventions exert an anti-obesity effect and attenuate liver dysfunction and steatosis.

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“…In a prospective study, the coffee consumption of patients with NAFLD was recorded at baseline, and 147 patients were followed for 7 years. Those who drank more coffee (3+ cups per day) had a lower fibrosis score 340 measured by a noninvasive fibrosis scoring system [74] . However 341 the strength of these conclusions is tempered by the inherent 342 methodological limitations including change in coffee consump-343 tion over time and limited diagnostic accuracy of non-invasive 344 scoring systems.…”

Section: Coffeementioning

confidence: 99%

Exercise and diet in the management of nonalcoholic fatty liver disease

Mahady

George

2016

Metabolism

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Coffee consumption and nonalcoholic fatty liver onset: a prospective study in the general population

Cited by 68 publications

References 39 publications

Coffee consumption is not associated with prevalent subclinical cardiovascular disease (CVD) or the risk of CVD events, in nonalcoholic fatty liver disease: results from the multi-ethnic study of atherosclerosis

Coffee consumption is not associated with prevalent subclinical cardiovascular disease (CVD) or the risk of CVD events, in nonalcoholic fatty liver disease: results from the multi-ethnic study of atherosclerosis

Long-term lifestyle interventions in middle-aged and elderly men with nonalcoholic fatty liver disease: a randomized controlled trial

Exercise and diet in the management of nonalcoholic fatty liver disease

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