Coffee Consumption and Cystatin-C-Based Estimated Glomerular Filtration Rates in Healthy Young Adults: Results of a Clinical Trial

Abstract

Recently it has been reported that the estimated glomerular filtration rate (eGFR) is higher in habitual coffee consumers than in noncoffee consumers. However, the causality remains unclear. Therefore, we conducted a clinical trial to investigate the effects of coffee consumption on kidney function. Nineteen asymptomatic nonsmokers aged 21–27 years old participated in this study. They consumed coffee (18 g coffee beans/450 mL per day) or green tea as a comparator for 2 weeks in a crossover design. Although creatinine-based eGFR was not affected after consuming either beverage, all cystatin-C-based eGFRs determined using five different equations were significantly increased after coffee consumption (means: 5.0–7.7%), but not after green tea consumption (means: 0.1–1.6%). Serum adiponectin and magnesium levels increased significantly after coffee consumption (means: 13.6% and 4.3%, resp.), but not after green tea consumption. These findings suggest that even a short period of coffee consumption may increase cystatin-C-based eGFR, along with favorable changes in serum adiponectin, in healthy young adults.

Evaluation of various biomarkers as potential mediators of the association between coffee consumption and incident type 2 diabetes in the EPIC-Potsdam Study , ,

“…Coffee consumption led to increased concentrations of adiponectin in several intervention studies (4)(5)(6). Similarly, coffee consumption was related to higher adiponectin concentrations among women in our study.…”

“…During recent years, a number of epidemiologic studies have found an inverse relationship between consumption of coffee and the risk of developing type 2 diabetes (T2D) 4 (2).…”

Nutrients, Nutraceuticals and Xenobiotics Affecting Renal Health

“…However, the effect of coffee and tea consumption on renal function, however, has been poorly investigated. In a cohort of Japanese adults, the consumption of coffee, but not tea, was associated to increased eGFR [140]. The same findings have been reported in another two studies performed in Japan [141,142].…”

Association between Coffee Consumption and Renal Impairment in Korean Women with and without Diabetes: Analysis of the Fourth Korea National Health and Nutrition Examination Survey in 2008

“…The results were significant and independent of the added sugar and level of high sensitivity C-reactive protein. One clinical trial of 19 young adults aged 21 to 27 years also showed that the consumption of ≥ 3 cups of coffee per day for 14 consecutive days is significantly associated with increased cystatin C-based eGFR as compared with subjects who consume green tea consumption 9). This finding suggests that even a short period of coffee consumption may have a favorable effect on kidney function.…”

“…Among such studies, an inverse association between coffee consumption and diabetes has been identified by a systematic review 6). Although there is a paucity of knowledge regarding the relationships between coffee consumption and the risk of renal function impairment, recent small-sized Japanese studies have suggested that habitual coffee consumption may be associated with normal or increased estimated glomerular filtration rate (eGFR) 7-9). Since renal function impairment is often caused by diabetes, even in the early stage of pathogenesis,10) one could speculate that coffee consumption may have favorable effects on kidney function via antidiabetic effects.…”