Coffee, Cirrhosis, and Transaminase Enzymes

Klatsky, Arthur L.; Morton, Cynthia C.; Udaltsova, Natalia; Friedman, Gary D.

doi:10.1001/archinte.166.11.1190

Cited by 180 publications

(153 citation statements)

References 32 publications

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“…9 Of interest is the fact that theophylline is a hepatic metabolite of caffeine and coffee drinking has been shown to protect against advanced alcoholic liver disease in large epidemiological studies. 21 Furthermore, pentoxifylline, another methyl xanthine compound similar in structure to both caffeine and theophylline with documented antitumor necrosis factor alpha properties, has been shown in trials to improve survival in AAH. 22 Pentoxifylline has been found to be ineffective as salvage therapy in AAH patients who have failed to respond to corticosteroids, 23 but true combination therapy has not been tested.…”

Section: Discussionmentioning

confidence: 99%

Theophylline improves steroid sensitivity in acute alcoholic hepatitis

et al. 2010

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Corticosteroid therapy has shown some benefit in severe acute alcoholic hepatitis (AAH); however, this is limited by uncertainty in patient selection and variable clinical response. Theophylline has been shown to ameliorate impaired steroid sensitivity in chronic obstructive pulmonary disease by facilitating corticosteroid-induced silencing of proinflammatory genes. We aimed to explore the mechanistic basis of the variable response to corticosteroid therapy seen in patients with AAH and to address the extent to which theophylline can improve this response. The ability of dexamethasone to inhibit phytohemagglutinin-induced lymphocyte proliferation was assessed by 3 H-thymidine incorporation in 12 severe AAH patients and age-matched and sex-matched controls. Steroid sensitivity was measured in terms of I max , the maximum inhibition of proliferation. The effect of 10 25 M theophylline and, in survivors, change in I max during recovery were observed. Lymphocyte steroid sensitivity was found to be significantly reduced in AAH compared with controls (I max 67[64.5]% versus 95[62.3]%, P 5 0.0002) and correlated with clinical markers of steroid responsiveness. In survivors, I max increased in recovery. Theophylline 10 25 M significantly increased lymphocyte steroid sensitivity (I max 86[66.6]% versus 67[65.0]%, P 5 0.027). Conclusion: Acute alcoholic hepatitis is associated with significant lymphocyte steroid insensitivity, which improves in recovery and can be ameliorated ex vivo by theophylline. This offers potential to rationalize corticosteroid prescribing in AAH and, furthermore, justifies investigation of this novel role for an existing pharmacological agent in this common and frequently fatal condition. (HEPATOLOGY 2010;52:126-131)

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Section: Discussionmentioning

confidence: 99%

Theophylline improves steroid sensitivity in acute alcoholic hepatitis

et al. 2010

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“…Other studies suggest that coffee consumption reduces the risk of Alzheimer's disease, Parkinson's disease, heart disease, diabetes mellitus type 2, cirrhosis of the liver (Klatsky et al, 2006), and gout ( Choi et al, 2007). Most of coffee's beneficial effects against type 2 diabetes are due to decaffeinated coffee (Pereira et al, 2006).…”

Section: Introductionmentioning

confidence: 99%

Kidney histotexure and serum creatinine level in response to concurrent administration of alcohol and coffee in mice

Islam¹,

Islam

Hossain

et al. 2016

Bangl. vet.

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The effect of alcohol and coffee on renal function with pathological changes in kidney was determined in mice. Sixty Albino mice were randomly divided into six equal groups. The mice of group A were maintained as control and remaining five groups were used as treated groups. The mice of control group were supplied with normal mice pellets whereas other groups were supplied with same pellets in addition to 5% coffee (in drinking water), 10% coffee, 10% alcohol, 5% coffee plus 5% alcohol and 10% coffee plus 10% alcohol, for 90 days. The serum creatinine level was significantly (P<0.01) higher in groups supplied with alcohol. There was huge infiltration of reactive cells and mild haemorrhagic spots in kidney of mice that received 10% coffee and 10% alcohol, respectively. It is suggested that long use of high doses of alcohol and coffee impaired kidney function. (Bangl. vet.

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“…Data on the potential beneficial effects of coffee on liver function and against liver diseases have accrued over the last two decades. Several epidemiologic studies have reported inverse associations of coffee drinking with levels of liver enzymes, 7,15,16) as well as with the risk of chronic liver diseases, 17) including liver cirrhosis 10,18) and even hepatocellular carcinoma. 11,19,20) The present epidemiological study revealed, for the first time, that coffee intake may protect against fatty liver.…”

Section: Discussionmentioning

confidence: 99%

Coffee Consumption is Associated with a Lower Incidence of Fatty Liver in Middle-aged Men

Funatsu

Yamashita

Nakamura

2011

JOURNAL OF HEALTH SCIENCE

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Whilst accumulating reports have shown the beneficial effects of coffee against chronic liver diseases, the effects of coffee against fatty liver have not yet been reported. In this cross-sectional and the followup studies, we investigated the effects of coffee on the production of fatty liver in healthy males, using ultrasonography. In the follow-up study, annual changes in daily coffee intake during the 5-year study period were compared between subjects who appeared to have fatty liver (fatty liver group) and those who did not appear to have fatty liver (non-fatty liver group) in the matched study according to age, body mass index (BMI) and daily exercise level. The effects of changes in daily coffee intake between both groups on the development of fatty liver were investigated after adjustments for related factors, such as BMI, daily coffee and alcohol intake and exercise level. In the cross-sectional study, the subjects with fatty liver were revealed to have a lower daily coffee intake than those without fatty liver. In the follow-up study, a significant difference in the changes in daily coffee intake was observed between the fatty liver and nonfatty liver groups with a decrease in daily coffee intake observed in the former group, compared with the change in the latter group. Further, daily coffee intake was negatively correlated with the development of fatty liver after adjustments for related factors. These findings suggest a protective effect of coffee against fatty liver.

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Coffee, Cirrhosis, and Transaminase Enzymes

Abstract: These data support the hypothesis that there is an ingredient in coffee that protects against cirrhosis, especially alcoholic cirrhosis.

Cited by 180 publications

References 32 publications

Theophylline improves steroid sensitivity in acute alcoholic hepatitis

Theophylline improves steroid sensitivity in acute alcoholic hepatitis

Kidney histotexure and serum creatinine level in response to concurrent administration of alcohol and coffee in mice

Coffee Consumption is Associated with a Lower Incidence of Fatty Liver in Middle-aged Men

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