Coffee and tea consumption and risk of prostate cancer in the European Prospective Investigation into Cancer and Nutrition

Abstract

The epidemiological evidence regarding the association of coffee and tea consumption with prostate cancer risk is inconclusive, and few cohort studies have assessed these associations by disease stage and grade. We examined the associations of coffee (total, caffeinated and decaffeinated) and tea intake with prostate cancer risk in the European Prospective Investigation into Cancer and Nutrition. Among 142,196 men, 7,036 incident prostate cancer cases were diagnosed over 14 years of follow-up. Data on coffee and tea consumption were collected through validated country-specific food questionnaires at baseline. We used Cox proportional hazards regression models to compute hazard ratios (HRs) and 95% confidence intervals (CI). Models were stratified by center and age, and adjusted for anthropometric, lifestyle and dietary factors. Median coffee and tea intake were 375 and 106 mL/day, respectively, but large variations existed by country. Comparing the highest (median of 855 mL/day) versus lowest (median of 103 mL/day) consumers of coffee and tea (450 vs. 12 mL/day) the HRs were 1.02 (95% CI, 0.94-1.09) and 0.98 (95% CI, 0.90-1.07) for risk of total prostate cancer and 0.97 (95% CI, 0.79-1.21) and 0.89 (95% CI, 0.70-1.13) for risk of fatal disease, respectively. No evidence of association was seen for consumption of total, caffeinated or decaffeinated coffee or tea and risk of total prostate cancer or cancer by stage, grade or fatality in this large cohort. Further investigations are needed to clarify whether an association exists by different preparations or by concentrations and constituents of these beverages.

Dietary Antioxidants in the Chemoprevention of Prostate Cancer

“…However, population-based study reported by Arab et al using data from the North Carolina-Louisiana Prostate Cancer Project showed no association between decaffeinated or caffeinated coffee (4 cups per day) and highly aggressive prostate cancer (OR 0.92, 95% CI 0.61-1.39) [69] (Table 2). Similarly, in a most recent European study, there was no evidence of association for risk of total prostate cancer or cancer by grade, grade or fatality, and consumption of total, decaffeinated, or caffeinated coffee [77]. The findings of these studies bring attention to potential anticancer effect of polyphenols in coffee in reducing progression and metastasis of prostate cancer.…”

“…In both studies, there was no association with prostate cancer and coffee consumption. In a large cohort European Study reported by Sen and colleagues, no association was observed for tea consumption and risk of prostate cancer by grade, stage, or fatality [77].…”

Dietary natural flavonoids treating cancer by targeting aryl hydrocarbon receptor

“…Although Paller et al found a negative correlation between high intake of quercetin and prostate cancer risk is described, this effect is not statistically significant (Paller et al 2015). Moreover, these were not reproduced by other effects about the role of quercetin in prostate carcinogenesis (Geybels et al 2013;Sen et al 2019). Similarly, a case-control study conducted with Italian women and a prospective investigation among American women revealed a 37-43% reduction in ovarian cancer incidence, including serous tumors (Gates et al 2007).…”

The Coffee–Acrylamide Apparent Paradox: An Example of Why the Health Impact of a Specific Compound in a Complex Mixture Should Not Be Evaluated in Isolation

“…The IARC experts also concluded a lack of association between coffee intake and prostate cancer risk [ 77 , 78 ]. More recent studies confirm this conclusion, with no evidence of association found regarding the consumption of total, caffeinated, or decaffeinated coffee and risk of total prostate cancer or cancer by stage, grade, or fatality in the large European Prospective Investigation into Cancer and Nutrition (EPIC) cohort [ 133 , 134 ].…”