Cofactors and comorbidities of necrobiosis lipoidica: analysis of the German DRG data from 2012

Jockenhöfer, Finja; Kröger, Knut; Klode, Joachim; Renner, Regina; Erfurt‐Berge, Cornelia; Dissemond, Joachim

doi:10.1111/ddg.12749

Cited by 29 publications

(38 citation statements)

References 35 publications

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“…Clinically, it is characterized by red-bluish papules that evolve into irregular, sharply demarcated yellowish plaques with telangiectases and an atrophic center. Although our patient was diabetic, his cutaneous lesions were not suggestive of necrobiosis lipoidica [ 7 ] .…”

Section: Diagnosis: Sarcoidosismentioning

confidence: 54%

A long history of widespread asymptomatic giant plaques

Chessa

Sacchelli

Misciali

et al. 2018

J Deutsche Derma Gesell

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Section: Diagnosis: Sarcoidosismentioning

confidence: 54%

A long history of widespread asymptomatic giant plaques

Chessa

Sacchelli

Misciali

et al. 2018

J Deutsche Derma Gesell

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“…Necrobiosis lipoidica is a chronic granulomatous dermatitis, and the peak age for presentation has been reported to be in the third and fourth decades . It is very rare in the pediatric population, and only a few isolated cases have been reported in individuals below the age of 10 years, all of which were patients with diabetes . The sex distribution of cohort studies showed a woman predominance .…”

Section: Discussionmentioning

confidence: 99%

“…NL is characterized by well‐demarcated oval or irregularly shaped, indurated plaques with yellow pigmentation at the center and red‐brown or violaceous pigmentation at the periphery. The average age of onset is 30 years, with women being affected more commonly . Few cases of necrobiosis lipoidica in atypical locations have been reported in children to date .…”

Section: Introductionmentioning

confidence: 99%

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Atypical presentation of necrobiosis lipoidica in a pediatric patient

Özkur

Hasçiçek

Altunay

2018

Pediatric Dermatology

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Necrobiosis lipoidica (NL) is a rare chronic granulomatous inflammatory skin disease characterized by brownish‐red papules and yellowish plaques with atrophic centers, which usually affect the legs, bilaterally. The average age of onset is 30‐40 years, and there are very few reported cases of necrobiosis lipoidica in children. A nondiabetic girl aged 14 years presented to our clinic with a history of an asymptomatic, 7 × 5‐cm single red plaque over her back in the interscapular area, which had started 5 years ago. Her laboratory tests were normal. A histopathologic evaluation confirmed the diagnosis of NL, and local treatment with clobetasol propionate twice daily was administrated. The patient will be followed up to monitor plasma glucose levels and evaluation of the lesion. Herein, we report a pediatric patient without diabetes mellitus who had NL in an atypical location and review the literature in view of the clinical features, complications, and treatment regimens for NL in children.

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“…Histologically, it is characterized by collagen degeneration, granuloma formation, and endothelial swelling. First described by Oppenheim in 1929 [ 1 ] , various studies have shown the prevalence of diabetes -at the time of NL diagnosis -to be somewhere between 30 % and 60 % [ 2 ] . Conversely, only approximately 3 % of diabetics develop NL over the course of their disease.…”

Section: Introductionmentioning

confidence: 99%

Update: Treatment of necrobiosis lipoidica

Peckruhn

Tittelbach

Elsner

2017

J Deutsche Derma Gesell

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SummaryNecrobiosis lipoidica (NL) is a rare granulomatous disease of hitherto unclear etiology frequently seen in patients with diabetes. Characterized by its potential for ulcerations, it often presents a serious burden for those affected. There are currently neither German nor European guidelines for the treatment of NL. At the same time, standard treatment with topical or intralesional corticosteroids does not always show satisfactory results. We therefore set out to evaluate whether the various treatment regimens published since 2000 have actually expanded the therapeutic armamentarium in a relevant manner. Included were all publications that described more than one patient being treated with any given therapeutic modality. Overall, we analyzed data for 16 different treatment regimens reported in 49 publications.The largest amount of data exists for topical PUVA therapy, photodynamic therapy (PDT), and systemic treatment with fumaric acid esters. Remarkably, our analysis showed that with an increase in the number of documented patients treated with a given therapeutic modality, the proportion of those achieving a complete or partial response actually decreased. This was interpreted as publication bias. Thus, no clear recommendation can be given for second-line therapy in case topical or intralesional corticosteroids fail.

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Cofactors and comorbidities of necrobiosis lipoidica: analysis of the German DRG data from 2012

Cited by 29 publications

References 35 publications

A long history of widespread asymptomatic giant plaques

A long history of widespread asymptomatic giant plaques

Atypical presentation of necrobiosis lipoidica in a pediatric patient

Update: Treatment of necrobiosis lipoidica

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