Coexpression of thyroid hormone receptor isoforms in mouse oligodendrocytes

Bury, Fabienne; Carré, Jean‐Luc; Vega, Sonia; Ghandour, Mohamedanwar; Rodrı́guez-Peña, Angeles; Langley, Keith; Sarliève, Louis L.

doi:10.1002/jnr.10111.abs

Cited by 4 publications

(3 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…THRb1 expression within the oligodendrocyte lineage has been somewhat controversial. While some groups (Baas et al, 1994a,b;Billon et al, 2001Billon et al, , 2002Bury et al, 2002) report expression in differentiated OLs but not OPCs, others have found THRb1 to be present in both cell types (Barres et al, 1994). These discrepant findings may be explained by changes in the expression of THRb1 within OPCs that are dependent on the "age" of the cell.…”

Section: Role Of Thrb1 In Oligodendrocyte Maturation and Myelinationmentioning

confidence: 99%

A selective thyroid hormone β receptor agonist enhances human and rodent oligodendrocyte differentiation

Baxi

Schott

Fairchild

et al. 2014

Glia

View full text Add to dashboard Cite

Nerve conduction within the mammalian central nervous system is made efficient by oligodendrocyte-derived myelin. Historically, thyroid hormones have a well described role in regulating oligodendrocyte differentiation and myelination during development, however, it remains unclear which thyroid hormone receptors are required to drive these effects. This is a question with clinical relevance since non-specific thyroid receptor stimulation can produce deleterious side-effects. Here we report that GC-1, a thyromimetic with selective thyroid receptor β action and a potentially limited side-effect profile, promotes in vitro oligodendrogenesis from both rodent and human oligodendrocyte progenitor cells. In addition, we used in vivo genetic fate tracing of oligodendrocyte progenitor cells via PDGFαR-CreER;Rosa26-eYFP double-transgenic mice to examine the effect of GC-1 on cellular fate and find that treatment with GC-1 during developmental myelination promotes oligodendrogenesis within the corpus callosum, occipital cortex and optic nerve. GC-1 was also observed to enhance the expression of the myelin proteins MBP, CNP and MAG within the same regions. These results indicate that a β receptor selective thyromimetic can enhance oligodendrocyte differentiation in vitro and during developmental myelination in vivo and warrants further study as a therapeutic agent for demyelinating models.

show abstract

Section: Role Of Thrb1 In Oligodendrocyte Maturation and Myelinationmentioning

confidence: 99%

A selective thyroid hormone β receptor agonist enhances human and rodent oligodendrocyte differentiation

Baxi

Schott

Fairchild

et al. 2014

Glia

View full text Add to dashboard Cite

show abstract

“…Thyroid hormones regulate brain development as attested by severe morphological, functional and cognitive impairments monitored in congenitally hypothyroid infants (Oppenheimer and Schwartz 1997). Particularly, they ensure normal oligodendrocyte maturation and myelination (McIntosh et al, 1981;Baas et al, 1997;Rodríguez-Peña 1999;Bury et al, 2002). There are two circulating thyroid hormones: thyroxin (T 4 ) and T 3 , and their action is transduced by thyroid hormone receptors (TRs), expressed in different cell types, including precursors and mature oligodendrocytes.…”

Section: Remyelination Induced By T 3 -Based Therapymentioning

confidence: 99%

Recovery from Chronic Demyelination by Thyroid Hormone Therapy: Myelinogenesis Induction and Assessment by Diffusion Tensor Magnetic Resonance Imaging

Harsan¹,

Steibel²,

Zaremba³

et al. 2008

J. Neurosci.

146

126

View full text Add to dashboard Cite

The failure of the remyelination processes in multiple sclerosis contributes to the formation of chronic demyelinated plaques that lead to severe neurological deficits. Long-term cuprizone treatment of C57BL/6 mice resulted in pronounced white matter pathology characterized by oligodendrocyte depletion, irreversible demyelination and persistent functional deficits after cuprizone withdrawal. The use of a combination of in vivo diffusion tensor magnetic resonance imaging (DT-MRI) and histological analyses allowed for an accurate longitudinal assessment of demyelination. Injection of triiodothyronine (T 3 ) hormone over a 3 week interval after cuprizone withdrawal progressively restored the normal DT-MRI phenotype accompanied by an improvement of clinical signs and remyelination. The effects of T 3 were not restricted to the later stages of remyelination but increased the expression of sonic hedgehog and the numbers of Olig2 ϩ and PSA-NCAM ϩ precursors and proliferative cells. Our findings establish a role for T 3 as an inducer of oligodendrocyte progenitor cells in adult mouse brain following chronic demyelination.

show abstract

“…There appears to be general consensus that both OPCs and OLGs express TRa and that OLGs express TRb (Carr e et al, 1998;Fierro-Renoy, 1995), in agreement with Bury et al (2002), who showed that TRa and TRb colocalize in OLGs before CNPase is expressed. Very recently, Baxi et al (2014) showed that a TRb agonist promotes oligodendrogenesis in rodents and in human OPCs in vitro.…”

Section: Discussionmentioning

confidence: 57%

Combined effects of transferrin and thyroid hormone during oligodendrogenesis In vitro

Marziali

Correale

Pasquini

2016

Glia

View full text Add to dashboard Cite

Thyroid hormones (THs) and transferrin (Tf) are factors capable of favoring myelination due to their positive effects on oligodendroglial cell (OLG) differentiation. The first notion of a combined effect of apotransferrin (aTf) and TH emerged from experiments conducted in young hyperthyroid animals, which showed a seven-fold increase in the expression of Tf mRNA and precocious myelination when compared with control animals. The mechanism underlying this phenomenon in young hyperthyroid rats could consist of an increase in Tf synthesis, which in the CNS is almost exclusively produced by OLG. Overall, our results show that, during the initial stages of OLG differentiation, Tf synthesis triggers thyroid hormone receptor alpha 1 (TRα1) expression in the subventricular zone (SVZ) and promotes proliferating cells to become responsive to this trophic factor. Exposure to TH could then regulate Tf expression through TRα1 and promote the induction of thyroid hormone receptor beta (TRβ) expression, which mediates TH effects on myelination through the activation of final OLG differentiation. This regulation of the combined effects of Tf and THs implies that both factors are fundamental actors during oligodendrogenesis. GLIA 2016;64:1879-1891.

show abstract

Coexpression of thyroid hormone receptor isoforms in mouse oligodendrocytes

Cited by 4 publications

References 0 publications

A selective thyroid hormone β receptor agonist enhances human and rodent oligodendrocyte differentiation

A selective thyroid hormone β receptor agonist enhances human and rodent oligodendrocyte differentiation

Recovery from Chronic Demyelination by Thyroid Hormone Therapy: Myelinogenesis Induction and Assessment by Diffusion Tensor Magnetic Resonance Imaging

Combined effects of transferrin and thyroid hormone during oligodendrogenesis In vitro

Contact Info

Product

Resources

About