Coexpression of organic anion‐transporting polypeptides <scp>1B3</scp> and multidrug‐resistant proteins 2 increases the enhancement effect of gadolinium‐ethoxybenzyl‐diethylenetriamine pentaacetic acid on hepatocellular carcinoma in magnetic resonance imaging

Kimura, Yoshihide; Sato, Shinya; Hitomi, Eiichi; Ohyama, Makoto; Adachi, Kazunori; Inagaki, Yusuke; Yamakawa, Yoshihiro; Hirano, Atsuyuki; Kawai, Hiroki; Tsuchida, Kenji; Senoo, Kyoji; Katsumi, Kohei; Joh, Takashi

doi:10.1111/hepr.12128

Cited by 6 publications

(7 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Tsuboyama et al reported that increased MRP2 expression in the pseudoglands of HCCs, under the existence of OATP8, was associated with HBP hyperintense HCCs [93]. Similarly, Kimura et al reported that HCCs with high expression levels of both OATP8 and MRP2 showed a higher relative enhancement ratio of HCC on HBP images than those with lower expression levels [19]. In addition, the expression of MRP3 in HCCs has been reported to be lower in hypointense HCCs than in isoor hyperintense HCCs [23].…”

Section: Signal Intensity On the Hepatobiliary Phase: A Potential Imamentioning

confidence: 98%

“…Indeed, there is cumulative evidence of the value of Gd-EOB-MRI for the detection of small HCCs [14], and for the differentiation between HCCs and other hepatic lesions or hypervascular pseudolesions [15][16][17]. Furthermore, there is an emerging issue regarding the value of HBP imaging of Gd-EOB-MRI for the evaluation of multistep hepatocarcinogenesis and for predicting the prognosis of HCCs after surgery or radiofrequency ablation [18][19][20][21][22][23]. Multistep hepatocarcinogenesis can be characterized by its hemodynamic changes.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Recent Advances in the Imaging Diagnosis of Hepatocellular Carcinoma: Value of Gadoxetic Acid-Enhanced MRI

Joo

Lee

2015

Liver Cancer

View full text Add to dashboard Cite

Magnetic resonance imaging (MRI) using gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid (Gd-EOB-DPTA), or gadoxetic acid for short, is a hepatocyte-specific contrast agent which is now increasingly used for the detection and characterization of focal hepatic lesions, particularly in patients at high-risk of developing hepatocellular carcinomas (HCC). In fact, several recent guidelines now recognize gadoxetic acid-enhanced MRI (Gd-EOB-MRI) as the primary diagnostic imaging modality for the noninvasive diagnosis of HCC, although it must be noted that several major guidelines still include only extracellular contrast media-enhanced computed tomography and MRI. The primary merits of Gd-EOB-MRI lie in the fact that it can provide not only dynamic imaging, but also hepatobiliary phase (HBP) imaging which can lead to high lesion-to-liver contrast and give additional information regarding hepatocyte uptake via organic anion transporting polypeptides. This, in turn, allows higher sensitivity in detecting small HCCs and helps provide additional information regarding the multistep process of hepatocarcinogenesis. Indeed, many recent studies have investigated the diagnostic value of Gd-EOB-MRI for early HCCs as well as its role as a potential imaging biomarker in predicting outcome. We herein review the recent advances in the imaging diagnosis of HCCs focusing on the applications of Gd-EOB-MRI and the challenging issues that remain.

show abstract

Section: Signal Intensity On the Hepatobiliary Phase: A Potential Imamentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

Recent Advances in the Imaging Diagnosis of Hepatocellular Carcinoma: Value of Gadoxetic Acid-Enhanced MRI

Joo

Lee

2015

Liver Cancer

View full text Add to dashboard Cite

show abstract

“…This includes organic anion transport factor 8 and organic transporter TP[11,15-17]. The enhancement also depends on the expression of multidrug resistance protein 2[16,17]. The use of Gd-EOB-DTPA to assess liver function has been reported following portal vein embolization[18,19].…”

Section: Discussionmentioning

confidence: 99%

Gd-EOB-DTPA based magnetic resonance imaging for predicting liver response to portal vein embolization

Szklaruk¹,

Luersen²,

Ma³

et al. 2017

WJR

View full text Add to dashboard Cite

AIMTo evaluate the correlation between degree of kinetic growth (kGR) of the liver following portal vein embolization (PVE) liver and the enhancement of the during the hepatobiliary phase of contrast administration and to evaluate if the enhancement can be used to predict response to PVE prior to the procedure.METHODSSeventeen patients were consented for the prospective study. All patients had an MR of the abdomen with Gd-EOB-DTPA. Fourteen patients underwent PVE. The correlation between the kGR of the liver and the degree of enhancement was evaluated with linear regression (strong assumptions) and Spearman’s correlation test (rank based, no assumptions). The correlation was examined for the whole liver, segments I, VIII, VII, VI, V, IV, right liver and left liver.RESULTSThere was no correlation between the degree of enhancement during the hepatobiliary phase and kGR for any segment, lobe of the liver or whole liver (P = 0.19 to 0.91 by Spearman’s correlation test).CONCLUSIONThe relative enhancement of the liver during the hepatobiliary phase with Gd-EOB-DTPA cannot be used to predict the liver response to PVE.

show abstract

“…However, MRP3 expression is usually weak in comparison to that of cholangiocytes [30]. In HCCs, MRP3 expression is either similar [24,30], increased [31], or decreased [19] in comparison to surrounding tissues. In tumour cells, MRP3 is localised in sinusoidal membranes [19,24,30,31] but positive staining in cytoplasm can be observed [19].…”

Section: Expression Of Mrp2 Mrp3 and Mrp4mentioning

confidence: 99%

“…In HCCs, MRP3 expression is either similar [24,30], increased [31], or decreased [19] in comparison to surrounding tissues. In tumour cells, MRP3 is localised in sinusoidal membranes [19,24,30,31] but positive staining in cytoplasm can be observed [19]. Kitao et al [23] reported that MRP3 expression was higher in isointense or hyperintense HCC than in hypointense HCC, raising the hypothesis than EOB-DTPA might return from tumour cells into sinusoids.…”

Section: Expression Of Mrp2 Mrp3 and Mrp4mentioning

confidence: 99%

Insights into the diagnosis of hepatocellular carcinomas with hepatobiliary MRI

Vilgrain

Beers

Pastor

2016

Journal of Hepatology

View full text Add to dashboard Cite

The incidence of hepatocellular carcinomas (HCCs) has increased worldwide in line with an improved screening by high-resolution imaging of cirrhotic livers. Besides abdominal ultrasonography and computerised tomography, magnetic resonance imaging (MRI) is an important tool to detect HCCs. With commercialisation of MR hepatobiliary contrast agents that cross membrane transporters in hepatocytes or tumour cells, MRI adds new information to detect and characterise HCCs. When tumour cells lose organic anion transporting polypeptides (OATP1B1/B3) in cell membranes facing sinusoidal blood, tumours appear hypointense (decreased contrast agent concentrations) in comparison to surrounding normal or cirrhotic liver that retains OATP1B1/B3 expression. However, expression, regulation, and prognostic significance of transporter evolution along carcinogenesis are not completely known. Moreover, understanding signal intensities in focal lesions also relies on transport functions of cellular efflux transporters. This manuscript reviews all the publications that associate liver imaging with hepatobiliary contrast agents and expression of transporters. The regulation of transporters along carcinogenesis to anticipate the prognosis of focal lesions is also included.

show abstract

Coexpression of organic anion‐transporting polypeptides 1B3 and multidrug‐resistant proteins 2 increases the enhancement effect of gadolinium‐ethoxybenzyl‐diethylenetriamine pentaacetic acid on hepatocellular carcinoma in magnetic resonance imaging

Abstract: We found that coexpression of OATP1B3 and MRP2 influenced the high contrast enhancement of HCC on MRI.

Cited by 6 publications

References 29 publications

Recent Advances in the Imaging Diagnosis of Hepatocellular Carcinoma: Value of Gadoxetic Acid-Enhanced MRI

Recent Advances in the Imaging Diagnosis of Hepatocellular Carcinoma: Value of Gadoxetic Acid-Enhanced MRI

Gd-EOB-DTPA based magnetic resonance imaging for predicting liver response to portal vein embolization

Insights into the diagnosis of hepatocellular carcinomas with hepatobiliary MRI

Contact Info

Product

Resources

About