Coexisting Thymic and Gastric Lymphomas of Mucosa-Associated Lymphoid Tissues in a Patient With Sjögren Syndrome

Nagasaka, Tetusuro; Lai, Raymond; Harada, Tomoko; Chen, Yuanyuan; Chen, Wen-Gang; Arber, Daniel A.; Weiss, Lawrence M.

doi:10.5858/2000-124-0770-ctaglo

Cited by 27 publications

(5 citation statements)

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“…Including the current series, 37 cases have been reported (Table 1). [3][4][5][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23] It is noteworthy that at least 28 (76%) of these patients are Asians, and at least 30 (81%) of them had autoimmune disease or hyperglobulinemia. 4 -23 All nine of our patients were Japanese and were seropositive for rheumatoid factor or antinuclear antibody.…”

Section: Discussionmentioning

confidence: 99%

Primary Thymic Mucosa-Associated Lymphoid Tissue Lymphoma: Diagnostic Tips

Shimizu

Kakegawa

Astumi

et al. 2010

Journal of Thoracic Oncology

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Mucosa-associated lymphoid tissue (MALT) lymphoma arising in the thymus is extremely rare and little is known regarding its clinicopathological features. This study examined the clinicopathological features of nine cases of thymic MALT lymphoma. Most patients had autoimmune disease or hyperglobulinemia, and they also had cysts in the tumors. Both increased serum autoantibody levels and polyclonal serum immunoglobulin levels remained essentially unchanged after total thymectomy in all patients. Thymic MALT lymphoma needs to be included in the differential diagnosis in Asian patients with a cystic thymic mass accompanied by autoimmune disease or hyperglobulinemia.

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Section: Discussionmentioning

confidence: 99%

Primary Thymic Mucosa-Associated Lymphoid Tissue Lymphoma: Diagnostic Tips

Shimizu

Kakegawa

Astumi

et al. 2010

Journal of Thoracic Oncology

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“…Two patients (both classified as Ann Arbor IV) had metastasis of other organs: one in the skin 12 months after surgery and another in the liver 6 years after surgery ( 12 , 39 ). One patient (classified as Ann Arbor III) ( 33 ) relapsed and died of cardiac shock eight months after his surgery, perhaps induced by tumor compression. The pooled event rate of case series was 5.01% (95% CI: 0.88–23.81%), and the forest plot was depicted in Figure 2 .…”

Section: Resultsmentioning

confidence: 99%

“…Together with radiotherapy, it was proved effective in one patient, which could not determine its value in thymic MALT lymphoma. Sixteen patients received postoperative systemic treatment in case reports, two of them had tumor relapse ( 33 , 39 ) and one patient died ( 33 ). Similarly, we could not evaluate the efficacy of postoperative systemic therapy in this rare disease.…”

Section: Discussionmentioning

confidence: 99%

A systematic review and meta-analysis of thymic mucosa-associated lymphoid tissue lymphoma

Zhou¹,

Chen²,

Zhang³

et al. 2022

J Thorac Dis

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Background Mucosa-associated lymphoid tissue (MALT) lymphoma of the thymus is a rare disease. The present meta-analysis aims at accumulating current evidence to explore the clinical characteristics, treatments, and prognoses of thymic MALT lymphoma. Methods We searched seven databases for studies published between the start date of database establishment and September 15, 2021. We included studies of patients with histological diagnoses and excluded those without data specifically on thymic MALT lymphoma. The quality was analyzed using an assessment tool. All data were tabulated. Pooled proportion was obtained using random-effects model. Statistical analysis was performed on R statistic software. Results Overall, 52 case reports and 13 case series were eligible. The quality of case reports was inferior to that of case series in terms of selection (P<0.001). Based on the analysis of patients in the case reports, age, gender, concurrent diseases, and tumor size did not differ between limited-stage and advanced-stage cases. Surgery is the mainstay to treat thymic MALT lymphoma. The surgical approach and extent did not influence the occurrence of events. Patients at Ann Arbor stage I were prone to not receiving postoperative therapy (P=0.011), though it may not reduce the occurrence of events (P=0.637). The five-year overall survival (OS) rate and five-year progression-free survival (PFS) rate were 97.2% and 88.4%, respectively. Patients with advanced-stage disease were more likely to suffer events (P=0.009). Conclusions Thymic MALT lymphoma is an extremely rare disease with a favorable prognosis. Currently available evidence is insufficient to draw solid judgments about treatment and prognosis. However, patients may benefit if thymectomy is chosen as the primary treatment. In some patients, lymph node sampling or dissection should be considered. In addition, if the patient is at an advanced-stage, postoperative therapy should be considered.

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“…Hypergammaglobulinemia and a serum IgA M-protein have been observed in some patients 92. Mediastinal lymphadenopathy or concomitant gastric, pulmonary, salivary gland, or conjunctival MALT lymphoma have been reported, and these cases are difficult to classify as to which organ was the primary site of disease 89,94,100–102. The prognosis of this tumor is excellent with the majority of patients free of disease after complete surgical resection 97,103…”

Section: Non-hodgkin B-cell Lymphomasmentioning

confidence: 99%

“…92 Mediastinal lymphadenopathy or concomitant gastric, pulmonary, salivary gland, or conjunctival MALT lymphoma have been reported, and these cases are difficult to classify as to which organ was the primary site of disease. 89,94,[100][101][102] The prognosis of this tumor is excellent with the majority of patients free of disease after complete surgical resection. 97,103 Imaging Thymic MALT lymphoma presents as a multiloculated or multicystic mass located in the anterior mediastinum on CT scan and MRI.…”

Section: Clinical Featuresmentioning

confidence: 99%

Mediastinal Lymphoproliferative Disorders

Piña‐Oviedo

2021

Advances in Anatomic Pathology

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Lymphoproliferative disorders comprise 50% to 60% of all mediastinal malignancies in both children and adults. Primary mediastinal involvement is rare (∼5%), whereas secondary mediastinal involvement by systemic disease is more common (10% to 25%). Primary mediastinal disease is defined as involvement by a lymphoproliferative disorder of mediastinal lymph nodes, the thymus, and/or extranodal mediastinal organs without evidence of systemic disease at presentation. In this review, the clinical, radiologic, histopathologic, immunohistochemical, and genetic features of some of the most characteristic mediastinal lymphoproliferative disorders are presented. The entities discussed here include: classic Hodgkin lymphoma with emphasis on nodular sclerosis and mixed cellularity types, and non-Hodgkin lymphomas, including primary mediastinal (thymic) large B-cell lymphoma, mediastinal gray zone lymphoma, mediastinal diffuse large B-cell lymphoma, thymic marginal zone lymphoma, mediastinal plasmacytoma, T-lymphoblastic lymphoma, and anaplastic large cell lymphoma. Although not a malignant process, hyaline vascular Castleman disease is also discussed here as this disorder commonly involves the mediastinum. Despite multiple advances in hematopathology in recent decades, the day-to-day diagnosis of these lesions still requires a morphologic approach and a proper selection of immunohistochemical markers. For this reason, it is crucial for general pathologists to be familiar with these entities and their particular clinicoradiologic presentation.

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Coexisting Thymic and Gastric Lymphomas of Mucosa-Associated Lymphoid Tissues in a Patient With Sjögren Syndrome

Cited by 27 publications

References 10 publications

Primary Thymic Mucosa-Associated Lymphoid Tissue Lymphoma: Diagnostic Tips

Primary Thymic Mucosa-Associated Lymphoid Tissue Lymphoma: Diagnostic Tips

A systematic review and meta-analysis of thymic mucosa-associated lymphoid tissue lymphoma

Mediastinal Lymphoproliferative Disorders

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