Coexisting Primary Cancers of Endometrium and Ovary: Experience of Single Institution

Abstract

Synchronous primary cancers of the endometrium and ovary (SEOC) occur in approximately 10% of all women with ovarian cancer and 5% of all women with endometrial cancer. Diagnosis of these tumors as independent primaries or metastases is necessary for appropriate staging and treatment. We aimed to demonstrate the clinic-pathological characteristics and prognosis of patients diagnosed as SEOC. Clinico-pathological data of cases with SEOC were retrieved from the computerized database of Etlik Zubeyde Hanim Women's Health and Research Hospital. Twenty-six patients with SEOC who underwent comprehensive surgical staging between 1998 and 2014 were included in study. Mean age at diagnosis of women with primary SEOC in our study was 50.9. Median follow up was 86.5 months and the 10 year overall survival (OS) rates were 86.0% for patients with SEOC. Among the variables only omental involvement independently affected OS (p= 0.008). Most of the tumors were well-differentiated, early stage and of endometrioid cell type. In this study we showed that women with SEOC was often young and mostly have an excellent prognosis.

Uterine involvement in epithelial ovarian cancer and its risk factors

“…AUB symptoms were reported in 61% of patients with synchronous endometrial cancer, while this was only in 5% of other patients. In fact, the most common chief complaint in these patients is AUB [ 13 , 15 , 23 – 27 ].…”