Coexisting lateral tibiofemoral osteoarthritis is associated with worse knee pain in patients with mild medial osteoarthritis

Iijima, Hirotaka; Aoyama, Tomoki; Nishitani, Kohei; Ito, Hiromu; Fukutani, Naoto; Isho, Takuya; Kaneda, Eishi; Kuroki, Hiroshi; Matsuda, Shuichi

doi:10.1016/j.joca.2017.02.801

Cited by 12 publications

(18 citation statements)

References 49 publications

(56 reference statements)

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“…Body mass index (BMI) was calculated by dividing the weight in kilograms by the square of height in meters. Radiographic OA severity of both knees in each participant was assessed in the anteroposterior short view in the weight-bearing position using the original version of the K&L grading system 7 as described in a previous study 13 . OA severity in the tibiofemoral joint was assessed by an experienced examiner (HI).…”

Section: Covariatesmentioning

confidence: 99%

Interaction between low back pain and knee pain contributes to disability level in individuals with knee osteoarthritis: a cross-sectional study

Iijima

Suzuki

Aoyama

et al. 2018

Osteoarthritis and Cartilage

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LBP interacts with knee pain intensity and contributes to disability level in individuals with knee OA. Coexisting LBP and knee pain had a stronger impact on disability level than LBP or knee pain alone. These findings highlight the potential deteriorative effects of the LBP-knee interaction on disability. Maximal treatment effects for disability might be achieved when LBP and knee pain are targeted simultaneously, rather than separately.

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Section: Covariatesmentioning

confidence: 99%

Interaction between low back pain and knee pain contributes to disability level in individuals with knee osteoarthritis: a cross-sectional study

Iijima

Suzuki

Aoyama

et al. 2018

Osteoarthritis and Cartilage

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“…The patient and physician assessments of therapy response were also determined (evaluation of medication: 0 = none: no good at all, ineffective drug; 1 = poor: some effect, but unsatisfactory; 2 = fair: reasonable effect, but could be better; 3 = good: satisfactory effect with occasional episodes of pain or stiffness; 4 = excellent: ideal response, virtually pain-free) [ 25 ]. Clinically significant improvement was defined as the decrease in pain exceeding 20 mm on the 0–100 mm VAS [ 22 ] and the achievement of at least 20% improvement from baseline with respect to the WOMAC score [ 24 , 26 – 28 ].…”

Section: Methodsmentioning

confidence: 99%

Long-Term Effectiveness of Polymerized-Type I Collagen Intra-Articular Injections in Patients with Symptomatic Knee Osteoarthritis: Clinical and Radiographic Evaluation in a Cohort Study

Borja-Flores¹,

Macías‐Hernández

Hernández-Molina

et al. 2020

Advances in Orthopedics

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Objective. Polymerized-type I collagen (polymerized-collagen) is a downregulator of inflammation and a tissue regenerator. The aim was to evaluate the effect of intra-articular injections (IAIs) of polymerized-collagen among patients with symptomatic knee osteoarthritis (OA) in delaying or preventing joint replacement surgery. Patients and Methods. This was a cohort study of 309 patients with knee OA. Patients with mild-to-moderate disease were treated weekly with IAIs of 2 mL of polymerized-collagen for six weeks (n = 309). Follow-up was for 6–60 months. The primary endpoints included the following determinations: (1) therapeutic effect; (2) survival from total knee replacement surgery (TKR); (3) Western Ontario and McMaster University Osteoarthritis Index (WOMAC) and pain (visual analogue scale, VAS). Clinical improvement was defined as a decrease in pain exceeding 20 mm on the VAS and the achievement of at least 20% improvement from baseline with respect to the WOMAC score. Radiographic analysis was performed at baseline and 60 months. The joint space width in the medial, lateral, and patellofemoral compartments was calculated. Results. Patients who received IAIs of polymerized-collagen had a statistically significant improvement in the primary criteria (p<0.05). Kaplan–Meier survival analysis of the therapeutic effect demonstrated 98.8% survival at 60 months with TKR as the endpoint. There was no significant reduction in joint space in any compartment based on the analyzed radiographs. No serious adverse events were recorded. Conclusion. Polymerized-collagen increased the time to TKR by at least 60 months, modifying the disease course, improving functional disability, and decreasing pain.

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“…Body mass index (BMI) was calculated by dividing the body mass in kilograms by the height in meters squared. Radiographic OA severity and anatomic axis angle (AAA) with sex‐specific correction of both knees were assessed in the anteroposterior short view in the weight‐bearing position, as in a previous study . Knee pain severity and disability level were evaluated using the Japanese Knee Osteoarthritis Measure (JKOM) subcategories of pain and stiffness (8 questions, range 0–32 points) and activities of daily living (10 questions, range 0–40 points) as a person‐specific assessment .…”

Section: Methodsmentioning

confidence: 99%

Relationship Between Varus Thrust During Gait and Low Back Pain in Individuals With Knee Osteoarthritis

Iijima

Suzuki

Aoyama

et al. 2020

Arthritis Care & Research

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Objective To test the hypothesis that varus thrust visualized during gait is associated with a higher prevalence of low back pain (LBP) in individuals with knee osteoarthritis (OA). Methods Individuals with knee OA (Kellgren/Lawrence grade ≥1) underwent a gait observation to assess varus thrust. The participants identified LBP and its severity using questionnaires. Logistic regression analyses were performed to examine the association between varus thrust and LBP. Results We included 205 participants (mean age 68.19 years; 72.20% women). A total of 45 participants (22.0%) showed varus thrust in their painful knee, in whom 31 (68.89%) and 18 (40.00%) were identified as having any LBP and moderate‐to‐severe LBP (numerical rating scale ≥4 points), respectively. Patients with varus thrust demonstrated a 3.6‐fold higher risk of the presence of moderate‐to‐severe LBP (95% confidence interval [95% CI] 1.62–8.10). In patients with LBP, the presence of varus thrust was associated with more severe LBP intensity (proportional odds ratio 2.25 [95% CI 1.02–4.96]). Conclusion This study highlights the novel relationship between varus thrust and LBP, which supports the idea of a biomechanical link, the so‐called knee–spine syndrome. These findings provide new insight for clarifying the pathogenesis of LBP related to knee OA.

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Coexisting lateral tibiofemoral osteoarthritis is associated with worse knee pain in patients with mild medial osteoarthritis

Abstract: Knees with concomitant lateral and mild medial OA may be more symptomatic compared to those without lateral OA. These findings might help to define a clinically distinct subgroup based on a simple radiographic finding in mild knee OA.

Cited by 12 publications

References 49 publications

Interaction between low back pain and knee pain contributes to disability level in individuals with knee osteoarthritis: a cross-sectional study

Interaction between low back pain and knee pain contributes to disability level in individuals with knee osteoarthritis: a cross-sectional study

Long-Term Effectiveness of Polymerized-Type I Collagen Intra-Articular Injections in Patients with Symptomatic Knee Osteoarthritis: Clinical and Radiographic Evaluation in a Cohort Study

Relationship Between Varus Thrust During Gait and Low Back Pain in Individuals With Knee Osteoarthritis

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