Coexisting gastrointestinal and hepatobiliary tract anomalies in omphalocele and gastroschisis: A twenty-year experience in a single tertiary medical center

Wen, Chen-Chen; Kuo, Tien-Chueh; Lee, Hung‐Chang; Yeung, Chun‐Yan; Chan, Wai-Tao; Jiang, Chuen-Bin; Sheu, Jin‐Chuan; Wang, Nien-Lu; Hsu, Chyong-Hsin; Weng, Shu-Chao; Tseng, Yufeng J.

doi:10.1016/j.pedneo.2022.03.009

Cited by 7 publications

(9 citation statements)

References 19 publications

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“…For omphalocele, the number of associated malformations ranges from 27% to 63%, and for gastroschisis, it ranges from 5% to 27%. 16,17 In a different study, 98 cases diagnosed with omphalocele in the first trimester were evaluated. 18 It was observed that 45.9% of the cases had major structural anomalies, and 53.8% had chromosomal anomalies.…”

Section: Discussionmentioning

confidence: 99%

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Omphalocele and gastroschisis: An analysis of prenatal diagnosis and neonatal outcomes

Doğru,

Akkuş,

Ezveci

et al. 2023

Sonography

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BackgroundOmphalocele and gastroschisis are the most frequent congenital developmental abdominal wall defects. Prenatal diagnosis of omphalocele and gastroschisis is critical in the management of the pregnancy, affording patients the option of termination. This study aims to evaluate the prenatal diagnosis and postnatal outcomes of omphalocele and gastroschisis cases.Materials and MethodsThe cases of gastroschisis and omphalocele diagnosed prenatally and followed up at our university were evaluated retrospectively between January 2019 and January 2022. Maternal demographic and clinical characteristics and perinatal outcomes were compared between the cases.ResultsThis study evaluated 42 omphalocele and nine gastroschisis cases. All gastroschisis cases were isolated (p = .001). Additional anomalies were present in 61.9% of omphalocele cases. While two patients with gastroschisis refused the invasive procedure, the genetic results of the others were normal. The karyotype was abnormal in 42.9% of omphalocele cases (p = .008). Half of the omphalocele cases were terminated, and 38.1% (n = 8) of the terminated omphalocele cases were trisomy 18. The coexistence of multiple system anomalies and cystic hygroma was high in the terminated cases. In all cases of gastroschisis, only the intestines protruded from the abdominal wall into the amniotic fluid. The number of survivors of omphalocele was 23.8%. The median hospital stay was 25 and 14 days for gastroschisis and omphalocele, respectively.ConclusionPrenatal diagnosis of omphalocele and gastroschisis is critical in pregnancy management. The presence of associated anomalies determines the prognosis of omphalocele and gastroschisis.

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Section: Discussionmentioning

confidence: 99%

“…The presence of associated anomalies determines the prognosis of omphalocele and gastroschisis. For omphalocele, the number of associated malformations ranges from 27% to 63%, and for gastroschisis, it ranges from 5% to 27% 16,17 . In a different study, 98 cases diagnosed with omphalocele in the first trimester were evaluated 18 .…”

Section: Discussionmentioning

confidence: 99%

Omphalocele and gastroschisis: An analysis of prenatal diagnosis and neonatal outcomes

Doğru,

Akkuş,

Ezveci

et al. 2023

Sonography

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“…10 The percentage of malrotation in the general population is 0.2-1%. 9 The incidence of true intestinal malrotation in a Systematic Review and Meta-Analysis made in 2018 was reported to be 3.5%, the diagnosis was usually made intra-operatively and it was observed to have an equal occurrence among patients with minor and major omphaloceles. 10 Our patient displayed additional physical abnormalities.…”

Section: Discussionmentioning

confidence: 99%

Perforated Meckel´s diverticulum in large omphalocele: a case report

Velasco-Villanueva,

K Trejo-Olguín

2023

JPNC

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Omphalocele is a midline abdominal wall defect that can be associated with other abnormalities. In this case report, we present a case of a newborn male with a perforated Meckel's diverticulum adherent within an omphalocele and intestinal malrotation; a very few cases of the coexistence of Omphalocele and Meckel's diverticulum have been described, so we highlight the multidisciplinary management. Consent to publish the case report was not obtained. This report does not contain any personal information that could lead to the identification of the patient. Since this is a case report we didn’t use any statistical tool. The validity and reliability of this case due to its detailed clinical account, citation of existing literature, and adherence to established medical knowledge.

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“…Gastroschisis and omphalocele are often identified through prenatal screening, and both mostly require surgical correction in childhood. However, the prevalence, embryogenesis, clinical characteristics, and the relation with potential associated anomalies of both congenital abdominal wall defects vary widely [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

“…Both gastroschisis and omphalocele can occur in isolation but might also be associated with additional anomalies [ 1 , 4 ]. Additional intestinal anomalies are well-known in patients with gastroschisis, as atresia at different levels of the intestinal tract can complicate the condition, defining gastroschisis in simple (i.e., without atresia) and complex gastroschisis (i.e., with atresia).…”

Section: Introductionmentioning

confidence: 99%

Additional Anomalies in Children with Gastroschisis and Omphalocele: A Retrospective Cohort Study

et al. 2023

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Background: Congenital abdominal wall defects might be associated with other anomalies, such as atresia in gastroschisis and cardiac anomalies in omphalocele patients. However, in the current literature, an overview of these additional anomalies and potential patient-specific risk factors is missing. Therefore, we aimed to assess the prevalence of associated anomalies and their patient-specific risk factors in patients with gastroschisis and omphalocele. Methods: A mono-center retrospective cohort study between 1997 and 2023 was performed. Outcomes were the presence of any additional anomalies. Risk factors were analyzed via logistic regression analysis. Results: In total, 122 patients were included, of whom 82 (67.2%) had gastroschisis, and 40 (32.8%) had omphalocele. Additional anomalies were identified in 26 gastroschisis patients (31.7%) and in 27 omphalocele patients (67.5%). In patients with gastroschisis, intestinal anomalies were most identified (n = 13, 15.9%), whereas, in patients with omphalocele, cardiac anomalies were most identified (n = 15, 37.5%). Logistic regression showed that cardiac anomalies were associated with complex gastroschisis (OR: 8.5; CI-95%: 1.4–49.5). Conclusions: In patients with gastroschisis and omphalocele, intestinal and cardiac anomalies were most identified, respectively. Cardiac anomalies were found to be a risk factor for patients with complex gastroschisis. Therefore, regardless of the type of gastroschisis and/or omphalocele, postnatal cardiac screening remains important.

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Coexisting gastrointestinal and hepatobiliary tract anomalies in omphalocele and gastroschisis: A twenty-year experience in a single tertiary medical center

Cited by 7 publications

References 19 publications

Omphalocele and gastroschisis: An analysis of prenatal diagnosis and neonatal outcomes

Omphalocele and gastroschisis: An analysis of prenatal diagnosis and neonatal outcomes

Perforated Meckel´s diverticulum in large omphalocele: a case report

Additional Anomalies in Children with Gastroschisis and Omphalocele: A Retrospective Cohort Study

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