Coexistent ulcerative colitis and Crohn's disease

Jones, Bronwyn; Gould, Stuart; Pollock, D. J.

doi:10.1136/pgmj.61.717.647

Cited by 3 publications

(3 citation statements)

References 12 publications

(13 reference statements)

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“…The same microorganism that causes the rare patient to develop both Crohn's disease and ulcerative colitis [ 26 - 29 ] usually causes some individuals to develop one disease or the other. Numerous studies of "mixed" families [ 30 - 34 ], where some individuals in a family develop ulcerative colitis and others develop Crohn's disease, are usually used to illustrate the idea that Crohn's disease and ulcerative colitis are genetic diseases, that some combination of genes causes both diseases.…”

Section: Discussionmentioning

confidence: 99%

Ulcerative colitis and Crohn's disease: is Mycobacterium avium subspecies paratuberculosis the common villain?

Pierce¹

2010

Gut Pathog

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Mycobacterium avium, subspecies paratuberculosis (MAP) causes a chronic disease of the intestines in dairy cows and a wide range of other animals, including nonhuman primates, called Johne's ("Yo-knee's") disease. MAP has been consistently identified by a variety of techniques in humans with Crohn's disease. The research investigating the presence of MAP in patients with Crohn's disease has often identified MAP in the "negative" ulcerative colitis controls as well, suggesting that ulcerative colitis is also caused by MAP. Like other infectious diseases, dose, route of infection, age, sex and genes influence whether an individual infected with MAP develops ulcerative colitis or Crohn's disease. The apparently opposite role of smoking, increasing the risk of Crohn's disease while decreasing the risk of ulcerative colitis, is explained by a more careful review of the literature that reveals smoking causes an increase in both diseases but switches the phenotype from ulcerative colitis to Crohn's disease. MAP as the sole etiologic agent of both ulcerative colitis and Crohn's disease explains their common epidemiology, geographic distribution and familial and sporadic clusters, providing a unified hypothesis for the prevention and cure of the no longer "idiopathic" inflammatory bowel diseases.

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Section: Discussionmentioning

confidence: 99%

Ulcerative colitis and Crohn's disease: is Mycobacterium avium subspecies paratuberculosis the common villain?

Pierce¹

2010

Gut Pathog

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“…A MEDLINE literature review contains only six welldocumented cases of coexisting CD and UC (6)(7)(8)(9)(10)(11). In three cases, Crohn's ileitis was the initial diagnosis (6)(7)(8), and UC developed following resection at varying time intervals.…”

Section: Discussionmentioning

confidence: 99%

“…In three cases, Crohn's ileitis was the initial diagnosis (6)(7)(8), and UC developed following resection at varying time intervals. In the three remaining reports, UC was the initial diagnosis, and when CD was subsequently diagnosed, both diseases were thought to be present concurrently (9,10,11). Table 2 summarizes the cases found in the literature and those described in this paper.…”

Section: Discussionmentioning

confidence: 99%

Two for One: Coexisting Ulcerative Colitis and Crohn’s Disease

Chen

Saibil

Morava-Protzner

2002

Canadian Journal of Gastroenterology

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Three cases of coexisting ulcerative colitis and Crohn's disease are presented. In the first case, the patient had a long-standing history of ulcerative proctitis before developing Crohn's colitis. In the two remaining cases, the patients presented initially with Crohn's disease of the ileum and, subsequent to resection, developed ulcerative colitis. Well-documented cases of patients diagnosed with both ulcerative colitis and Crohn's disease are rare. The literature on such cases is reviewed, and the controversy over whether ulcerative colitis and Crohn's disease are two distinct diseases is explored.

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The differential diagnosis of idiopathic inflammatory disease by colorectal biopsy

Hamilton

1987

Int J Colorect Dis

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The differential diagnosis of idiopathic inflammatory bowel disease by colorectal biopsy poses a challenge to the endoscopist as well as the pathologist. Distinguishing non-idiopathic colitis from idiopathic colitis is the fundamental first step. No single histopathologic feature distinguishes between non-idiopathic and idiopathic inflammatory bowel disease or between the two forms of idiopathic inflammatory bowel disease (ulcerative colitis and Crohn's disease involving the colon). Interaction between the endoscopist and pathologist is essential in optimizing the contribution of colorectal biopsy to management of patients with inflammatory bowel disease.

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Coexistent ulcerative colitis and Crohn's disease

Cited by 3 publications

References 12 publications

Ulcerative colitis and Crohn's disease: is Mycobacterium avium subspecies paratuberculosis the common villain?

Ulcerative colitis and Crohn's disease: is Mycobacterium avium subspecies paratuberculosis the common villain?

Two for One: Coexisting Ulcerative Colitis and Crohn’s Disease

The differential diagnosis of idiopathic inflammatory disease by colorectal biopsy

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