Coexistent hemangioblastoma and arteriovenous malformation of the cerebellum

Medvedev, Yuri; Matsko, D E; Zubkov, Yuri N.; Pak, V.; Alexander, Lon F.

doi:10.3171/jns.1991.75.1.0121

Cited by 18 publications

(17 citation statements)

References 18 publications

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“…The term "angioglioma" was first used by Councilman 3 in 1914 to describe cerebellar hemangioblastomas, but has been used more broadly to describe neoplasms involving vascular malformations. Despite the few reports of hemangioblastomas 15,18 and meningiomas 2 associated with arteriovenous shunts, the great majority of dualpathology lesions composed of arteriovenous shunts and neoplasms have involved tumors of glial origin. The existing literature describing arteriovenous shunts and gliomas diagnosed simultaneously as a combined lesion consists of a few case reports.…”

Section: Discussionmentioning

confidence: 99%

De novo formation of large arteriovenous shunting and a vascular nidus mimicking an arteriovenous malformation within an anaplastic oligodendroglioma: treatment with embolization and resection

McKinney¹,

Steineke

Nochlin

et al. 2008

JNS

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The authors report the de novo occurrence and treatment of an arteriovenous lesion within an anaplastic oligodendroglioma in a patient with previously unremarkable brain imaging. Intracranial arteriovenous malformations (AVMs) are believed to be congenitally acquired lesions, and their association with brain neoplasms is extremely rare. Diagnostic imaging revealed a mass lesion with large arteriovenous shunts and a vascular nidus mimicking a true AVM. Histological and immunohistochemical testing showed an anaplastic oligodendroglioma mixed with an AVM. The clinical, radiological, and operative data are reviewed, as are the histopathological findings. To the authors' knowledge this is the first case of de novo occurrence of an arteriovenous lesion with large shunts and a vascular nidus within an anaplastic oligodendroglioma.

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Section: Discussionmentioning

confidence: 99%

De novo formation of large arteriovenous shunting and a vascular nidus mimicking an arteriovenous malformation within an anaplastic oligodendroglioma: treatment with embolization and resection

McKinney¹,

Steineke

Nochlin

et al. 2008

JNS

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“…The presence of a few dysplastic vessels as well as a component of a capillary angioma at the periphery of the sarcoma, although not conclusive, is compatible with such interpretation. There are at least two reports of association of hemangioblastoma with vascular malformations [ 47,48] . Although development of angiosarcoma in preexisting vascular malformation or angioma has not been described in the brain, this possibility cannot be excluded in the presented case.…”

Section: Fig 5 Angiosarcoma Cells In the Intercapillary Stroma The mentioning

confidence: 99%

Primary Composite Angiogenic Leiomyosarcoma?Epithelioid Angiosarcoma of the Brain

Lach

Benoit

2000

Ultrastructural Pathology

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The authors describe a primary sarcoma of the brain with immunohistochemical and ultrastructural features of leiomyosarcoma as well as epithelioid hemangiosarcoma. The leiomyosarcomatous component consisted of spindle cells with well-developed external lamina, subsarcolemmal densities composed of micro® laments, pinocytic vesicles, and abundant intermediate ® laments, and showed immunohistochemical reactions for smooth muscle actin. The epithelioid part of the tumor contained scattered cells reactive for alkaline phosphatase as well as CD31 and factor VIII. Many epithelioid cells were lipidized and remarkably similar to``stromal cells'' of a hemangioblastoma. Occasional Weibel-Palade bodies, indicating endothelial differentiation, were present in scattered neoplastic cells. There were also cells with features intermediate between endothelium, pericytes and smooth muscle cells, and undifferentiated mesenchymal cells. The brain at the periphery of sarcoma showed conglomerates of well-differentiated capillaries, telangiectasias and small dysplastic arteries, features that raise the possibility of origin of this tumor from a preexisting vascular developmental abnormality.

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“…

NUMBER of investigators have described the association of aneurysms and cerebral lesions such as tumors 13,21 or vascular malformations 4,8,10,20 in the same patient. Different theories about the causes, pathophysiological mechanisms, and treatment modalities of these coexistent pathological entities have been suggested.

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confidence: 99%

An intracranial aneurysm on the feeding artery of a cerebellar hemangioblastoma

Guzman¹,

Grady²

1999

Journal of Neurosurgery

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A case of cerebellar hemangioblastoma with a coexistent arterial aneurysm on the feeding artery of the tumor is reported. The patient presented with an acute onset of headache, loss of consciousness, and left-sided hemiparesis due to a posterior fossa hemorrhage found adjacent to a hemangioblastoma. Four-vessel angiography revealed an aneurysm on the anterior inferior cerebellar artery (AICA), which was the main feeding vessel of the hemangioblastoma. Successful total excision of the hemangioblastoma and clipping of the AICA aneurysm achieved in a one-stage operation was demonstrated on postoperative angiography.

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Coexistent hemangioblastoma and arteriovenous malformation of the cerebellum

Abstract: A case of cerebellar hemangioblastoma and coexistent arteriovenous malformation (AVM) is presented. Angiography displayed the AVM, but histological examination revealed a coexisting hemangioblastoma. Various theories concerning the etiology of this condition are discussed.

Cited by 18 publications

References 18 publications

De novo formation of large arteriovenous shunting and a vascular nidus mimicking an arteriovenous malformation within an anaplastic oligodendroglioma: treatment with embolization and resection

De novo formation of large arteriovenous shunting and a vascular nidus mimicking an arteriovenous malformation within an anaplastic oligodendroglioma: treatment with embolization and resection

Primary Composite Angiogenic Leiomyosarcoma?Epithelioid Angiosarcoma of the Brain

An intracranial aneurysm on the feeding artery of a cerebellar hemangioblastoma

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