Coexistence of uterine adenomyosis is not associated with a better prognosis in endometrioid-type endometrial cancer

Aslan, Koray; Sarı, Mustafa; Yalçin, Hakan; Yalçın, İbrahim; Cüylan, Zeliha Fırat; Özdal, Bülent

doi:10.1007/s11845-020-02172-z

Cited by 7 publications

(5 citation statements)

References 23 publications

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“…Lately, Koray et al, determined the effects of adenomyosis on the aggressiveness of endometrial cancer. Although, adenomyosis was not noticed to be an independent prognostic factor for endometrial tumor, they detected a better prognosis on such cases [26]. On the other hand, in a large pilot study, the authors did not find any significant difference between patients with coexistence of endometrial cancer and adenomyosis in comparison to isolated endometrial cancer cases in terms of epidemiologic, clinopathologic and prognostic characteristics [27].…”

Section: Discussionmentioning

confidence: 85%

There is no significant correlation of adenomyosis with benign, premalignant and malignant gynecological pathologies. Retrospective study on 647 specimens

et al. 2022

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Section: Discussionmentioning

confidence: 85%

There is no significant correlation of adenomyosis with benign, premalignant and malignant gynecological pathologies. Retrospective study on 647 specimens

et al. 2022

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“…Furthermore, the study by Aslan et al showed similar overall survival between women with endometrial cancer with or without adenomyosis and did find similar factors associated with prolonged survival. 9 In our study, only women with endometrioid endometrial cancer were included, possibly resulting in a different outcome.…”

Section: Discussionmentioning

confidence: 99%

“… 7 Another study showed that adenomyosis was not an independent prognostic factor after correcting for confounders in 103 women with adenomyosis with endometrial cancer. 9 Additionally a recent case‐control study, did not find different survival for women with endometriosis or adenomyosis and endometrial cancer. 10 Due to small sample sizes and lack of correction for confounders, larger studies are warranted to study the role of endometriosis and adenomyosis in endometrial cancer survival.…”

Section: Introductionmentioning

confidence: 94%

“…A recent meta‐analysis showed in crude analysis that women with adenomyosis and endometrial cancer have an increased overall survival when compared to women with endometrial cancer without adenomyosis 7 . Another study showed that adenomyosis was not an independent prognostic factor after correcting for confounders in 103 women with adenomyosis with endometrial cancer 9 . Additionally a recent case‐control study, did not find different survival for women with endometriosis or adenomyosis and endometrial cancer 10 .…”

Section: Introductionmentioning

confidence: 98%

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Endometrial cancer prognosis in women with endometriosis and adenomyosis: A retrospective nationwide cohort study of 40 840 women

Hermens

Altena

et al. 2021

Intl Journal of Cancer

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We aim to compare endometrial cancer survival in women with or without histological proven endometriosis or adenomyosis. We identified all women with endometrial cancer between 1990 and 2015 from the Netherlands Cancer Registry (NCR). Data were linked to the Dutch pathology database (PALGA) to select all women with histological proven endometriosis/adenomyosis. Overall survival was compared between women with endometrial cancer with or without endometriosis/adenomyosis. We used multivariable Cox proportional hazard analysis to estimate hazard ratios (HRs). We included 1701 women with endometrial cancer and endometriosis/adenomyosis, of whom 1236 (72.7%) women had adenomyosis, 320 (18.8%) had endometriosis and 145 (8.5%) had both. We compared these women to 39 139 women with endometrial cancer without endometriosis/adenomyosis. Women in the combined endometriosis/adenomyosis cohort were younger at endometrial cancer diagnosis, had earlier disease stage, more often had endometrioid endometrial cancer and low grade tumors. The 5‐year survival rate in the combined endometriosis/adenomyosis cohort was 84.8% (95% CI 84.6‐88.1) and 71.6% (95% CI 71.1‐72.0) in the nonendometriosis/adenomyosis cohort. Univariable analysis resulted in a crude HR of 0.63 (95% CI 0.59‐0.69). Significant confounding factors were age, stage, cancer subtype, histological grading, surgery and chemotherapy rate. Correction for these confounders resulted in a HR of 0.98 (95% CI 0.90‐1.06). Including endometriosis/adenomyosis status as a categorical factor resulted in similar HRs. In conclusion, women with endometrial cancer and histologically proven endometriosis/adenomyosis have a better overall survival when compared to women with endometrial cancer without endometriosis/adenomyosis. This better survival was correlated to stage, grade, age and histological subtype, but not to the presence of endometriosis/adenomyosis.

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“…Recent research has shed light on the impact of adenomyosis on the aggressiveness of endometrial cancer. While adenomyosis has not been established as an independent prognostic factor for endometrial tumors, cases of endometrial cancer combined with adenomyosis tend to have better prognoses (37). A study in 2022 further con rmed increased survival rates among women with endometrial cancer and histologically proven endometriosis or adenomyosis (38).…”

Section: Adenomyosis With Abnormal Ectopic Endometrial Pathologymentioning

confidence: 99%

Retrospective Study on the Incidence of Benign, Premalignant, and Malignant Gynecologic Disorders in Patients with Adenomyosis: Analysis of 5648 Specimens

Cao,

Li,

Ding

2024

Preprint

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Adenomyosis is an estrogen-dependent disease and ranks among the most common gynecological benign conditions in women of childbearing age. Adenomyosis has been reported to coincide with endometrial hyperplasia, polyps, and even endometrial cancer. This study aims to investigate the incidence of benign, premalignant, and malignant gynecological diseases in women undergoing gynecological surgery for adenomyosis. A retrospective review of medical records collected from January 2021 to May 2023 for surgeries performed at the Obstetrics and Gynecology Hospital affiliated with Fudan University was conducted. Pathology reports of 5648 cases of adenomyosis were studied. The incidence of benign, premalignant, and malignant gynecological pathologies in women with adenomyosis who underwent gynecological surgery were analyzed. The mean age of women with adenomyosis was 49.0 ± 9.0 years. Adenomyosis without other gynecological pathologies was detected in 16.7% of specimens of 5648 patients, while coexistence with one or more gynecological pathologies was present in 82.3% of cases. Additionally, coexistence with two or more gynecological diseases (benign or malignant) was present in 1806 of 5648 patients (31.9%). The most common comorbidities were uterine leiomyoma (57.1%), followed by endometrial cancer (11.8%) and endometriosis (10.7%). Furthermore, we found that women with adenomyosis, leiomyoma, endometriosis, endometrial polyps, or atypical hyperplasia were younger (p < 0.05) compared with adenomyotic patients with malignant tumors. Adenomyosis is a common benign, progressive disease that has garnered increasing attention in recent years. Some studies have suggested a potential association of adenomyosis with several gynecological diseases. Our study shows a high prevalence of endometrial cancer in patients with adenomyosis compared to the general population.

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Coexistence of uterine adenomyosis is not associated with a better prognosis in endometrioid-type endometrial cancer

Cited by 7 publications

References 23 publications

There is no significant correlation of adenomyosis with benign, premalignant and malignant gynecological pathologies. Retrospective study on 647 specimens

There is no significant correlation of adenomyosis with benign, premalignant and malignant gynecological pathologies. Retrospective study on 647 specimens

Endometrial cancer prognosis in women with endometriosis and adenomyosis: A retrospective nationwide cohort study of 40 840 women

Retrospective Study on the Incidence of Benign, Premalignant, and Malignant Gynecologic Disorders in Patients with Adenomyosis: Analysis of 5648 Specimens

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