Coexistence of thyroid autoimmunity with other autoimmune diseases: Friend or foe? Additional aspects on the mosaic of autoimmunity

Szyper‐Kravitz, Martine; Marai, Ibrahim; Shoenfeld, Yehuda

doi:10.1080/08916930500050194

Cited by 82 publications

(63 citation statements)

References 55 publications

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“…Lichen planus has been associated to a number of disorders, generally of autoimmune origin: myasthenia gravis, Sjogren's syndrome, ulcerative colitis, psoriasis, thymoma, lupus erythematous, coeliac disease [1]. Likewise, Sjogren's syndrome, lupus erythematous, type 1 diabetes, pernicious anaemia, surrenal deficiency and Grave's disease were considered as HTassociated disorders [2]. To the best of our knowledge, no one reported so far the association between OLP and HT.…”

Section: Introductionmentioning

confidence: 99%

Possible link between Hashimoto's thyroiditis and oral lichen planus: a novel association found

et al. 2012

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Objectives Hashimoto's thyroiditis as well as lichen planus has been associated to a number of disorders, generally of auto-immune origin. A novel possible association between oral lichen planus (OLP) and Hashimoto's thyroiditis (HT) is here proposed on the basis of a cross-sectional survey. Materials and methods One hundred and five unrelated OLP patients were considered. Diagnosis of HT was based on positive serum anti-TPO, anti-Tg, TSH levels and the typical ultrasound pattern of the thyroid gland. Results In the present survey, the prevalence of HT in the OLP group was 14.3 % whereas the prevalence of HTrelated hypothyroidism in the general population was reported to be equal to 1 %. By Fisher's exact test, it was revealed that the difference between our data and historical prevalence of HT was found statistically significant. Conclusion Actually, there is no definitive hypothesis that could explain the coexistence of OLP and HT. However, considering the onset timing of HT followed by OLP in 93.3 % of our series, we suspected a causal or predisposing role for HT. Specifically, we believe that in HT patients, circulating thyroid antibodies could contribute to trigger an organ-specific auto-immune response also in the oral mucosa or skin, leading to the development of LP lesions. Clinical relevance Because of the large number of cases of asymptomatic chronic auto-immune thyroiditis, it would be useful that women over 40 years of age affected by OLP were screened for thyroid dysfunction, particularly HT.

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Section: Introductionmentioning

confidence: 99%

Possible link between Hashimoto's thyroiditis and oral lichen planus: a novel association found

et al. 2012

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“…Since thyroid disease represents a prevalence of 14% to 20% in women who have SLE and Sjogren syndrome [52], assessment of sick infants who have NLS should include evaluation for thyroid dysfunction and maternally derived blocking and stimulating thyroid antibodies. Women who have hypothyroidism and SSA/Ro antibodies have a nine fold increased risk for delivering a child who has CHB compared with women who have only SSA/Ro antibodies [53].…”

Section: Endocrine Manifestationsmentioning

confidence: 99%

Neonatal Lupus Erythematosus

Nasef

Hafez²,

Bakr³

2014

NCP

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Neonatal lupus is a passively acquired autoimmune disease that occurs in offspring of mothers with anti-SSA/Ro and/or anti-SSB/La antibodies. The primary clinical features are a photosensitive rash that is usually found on the scalp and periorbital areas, congenital heart block with or without cardiomyopathy, cytopenias, disseminated intravascular coagulation, and neonatal cholestasis with or without elevated transaminases. The diagnosis is usually made in utero by detection of a slow fetal heart rate and subsequent fetal echocardiographic confirmation of heart block and/or cardiomyopathy. Prenatal treatment with fluorinated glucocorticoids beginning as soon after detection has favourable outcome for mothers of fetuses with second degree heart block, is of no value for mothers of fetuses with third degree heart block, and controversial for mothers of fetuses with first degree heart block. Prenatal glucocorticoids can be used also in presence of cardiomyopathy associated with neonatal lupus. Hydroxychloroquine has been used in pregnant women who have anti-SSA/Ro antibodies and who have previously given birth to a child with cardiac manifestations. First and second degree block, detected in utero or at birth, can progress to complete heart block. Infants with complete heart block usually require a pacemaker with an excellent prognosis, although development of heart failure may occur.

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“…17 Autoimmune thyroiditis has been linked to infections with EBV, HTLV-1, hepatitis C virus, and Yersinia enterocolitica. 5 Specific infections were suggested to be a triggering factor for the initiation of disease by liberating antigens (via cell destruction or apoptosis), by forming altered antigens or causing molecular mimicry, by cytokine and chemokine secretion, and by inducing aberrant HLA-DR expression and Toll-Like Receptor (TLR) activation.…”

Section: Discussionmentioning

confidence: 99%

The Relationship Between Parvovirüs B19 and Hashimoto\'s Thyroiditis

Erden¹,

Çıftçı²,

Çınar³

et al. 2013

Turkiye Klinikleri J Med Sci

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98ashimoto's thyroiditis (HT) is the most common and extensively studied organ-specific autoimmune disorder in humans. 1,2 It is characterized by diffuse lymphocytic infiltration of the thyroid gland, elevated levels of the serum antithyroid antibodies (ATA) The chi-square test and unpaired t-test were used for the comparison between the groups. R Re es su ul lt ts s: : Anti-parvo virus IgM antibodies were positive in 6 (11.1%) patients and 3 (5.7%) controls while anti-parvo virus IgG antibodies were present in 14 (25.9%) patients and 8 (22.9 %) controls. There was no significant difference between the patient and control groups in terms of antibody positivity (p=0.409, p=0.478). C Co on nc cl lu us si io on n: : Although the prevalence of antiviral antibodies were higher in patients with HT compared to those in the control group, the difference was not statistically significant. This was attributed to the small number of patients. Nevertheless, this finding may reflect a viral contribution in the pathogenesis of HT.

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Coexistence of thyroid autoimmunity with other autoimmune diseases: Friend or foe? Additional aspects on the mosaic of autoimmunity

Cited by 82 publications

References 55 publications

Possible link between Hashimoto's thyroiditis and oral lichen planus: a novel association found

Possible link between Hashimoto's thyroiditis and oral lichen planus: a novel association found

Neonatal Lupus Erythematosus

The Relationship Between Parvovirüs B19 and Hashimoto\'s Thyroiditis

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