Coexistence of systemic sclerosis, scleroderma-like syndromes and neoplastic diseases

Abstract

Coexistence of systemic sclerosis, scleroderma-like syndromes and neoplastic diseases 119 REVIEW ARTICLES Neoplastic diseases and rheumatic syndromes A number of rheumatic diseases coexisting with neoplasm of various origins have been reported. Neoplastic lesions changes may evoke the paraneoplastic rheumatic syndromes. Moreover, they may be a complication of chronic rheumatic disease [1]. Paraneoplastic syndrome is defined as a sign or a constellation of signs and symptoms which are secondary to the presence of a malignancy. These symptoms may be induced to the substances secreted by the neoplasm (hormones and other biologically active substances) or to the immune system response to tumor cells (autoimmunological reactions, immune complexes, immune system suppression) and may involve many organs and systems. Paraneoplastic syndromes are not related to

Limited Scleroderma with Pauci-Immune Glomerulonephritis in the Presence of Renal Cell Carcinoma

“…Unfortunately, we can only speculate regarding pathogenesis, since primary and paraneoplastic presentations of connective tissue disorders are indistinguishable. 5 Although the initial discovery of our patient's connective tissue disorder and malignancy occurred in the inpatient setting, treatment was initiated as an outpatient. Unfortunately, the partial nephrectomy was scheduled one month after discharge.…”

Paraneoplastic rheumatic syndromes: report of eight cases and review of literature

“…The clinical table includes cutaneous sclerosis of fingers similar to those found in SS, which sometimes progresses to the proximal extremities and trunk. Raynaud's phenomenon is less common [15]. The antinuclear antibodies (ANA) are more often negative than in the idiopathic SS and anticentromere antibodies (ACA), anti-topoisomerase I antibodies (anti-SCl-70) antifibrillarin and anti-RNA polymerase III are not detected in these patients [15].…”

“…Raynaud's phenomenon is less common [15]. The antinuclear antibodies (ANA) are more often negative than in the idiopathic SS and anticentromere antibodies (ACA), anti-topoisomerase I antibodies (anti-SCl-70) antifibrillarin and anti-RNA polymerase III are not detected in these patients [15]. Furthermore, our observation, interestingly, note that clinical and immunological changes found in idiopathic forms of SS may be present in patients with paraneoplastic scleroderma like syndrome; presence of Raynaud's phenomenon, dyspnea, digital clubbing, acrocyanosis and positivity of ANA and anti-SCl-70 antibodies.…”

Case of lung carcinoma revealed by vulvar metastasis associated with systemic scleroderma and literature review

“…Therefore, the history of scleroderma, with disease duration of 18 years and the lack of improvement of scleroderma lesion after lung chemotherapy suggested a probable absence of a paraneoplastic syndrome in our case. 2,3 So, this lung cancer was probably a secondary tumor to patient's systemic scleroderma.…”