“…1 Histology is characterized by a lack of oxytalan and eulanin elastic fibers in the papillary dermis. 2,3 Affected sites in PXE-PDE include chiefly flexural areas: the neck; supraclavicular region; scalp; axillae; lower aspect of abdomen/inguinal region; and antecubital fossa. 1,2,[4][5][6][7][8] Mild pruritus can occur in the involved region.…”
“…1 Histology is characterized by a lack of oxytalan and eulanin elastic fibers in the papillary dermis. 2,3 Affected sites in PXE-PDE include chiefly flexural areas: the neck; supraclavicular region; scalp; axillae; lower aspect of abdomen/inguinal region; and antecubital fossa. 1,2,[4][5][6][7][8] Mild pruritus can occur in the involved region.…”
“…Immunohistochemical staining may show loss of fibrillin-1 and -2 and microfibril-associated glycoprotein-1 and -2 in the papillary dermis. 99,101 These elastogenic changes may reflect an active repair process of elastolytic damage and are thought to be consistent with intrinsic or chronologic aging. 102 Associated conditions.…”
“…28,29 Elastin, fibrillin-1, fibrillin-2, and microfibril-associated glycoprotein-1 and -4 may be decreased in or absent from the papillary dermis of lesional skin. 30 Associated conditions. Linear focal elastosis has not been associated with systemic involvement.…”
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.