Coexistence of peptide YY and glicentin immunoreactivity in endocrine cells of the gut

Böttcher, Gerhard; Sjölund, K.; Ekblad, Eva; Håkanson, R.; Schwartz, Thue W.; Sundler, F.

doi:10.1016/0167-0115(84)90034-x

Cited by 180 publications

(63 citation statements)

References 18 publications

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“…In response to feeding, PYY and GLP-1 are both secreted from endocrine L-cells of the distal ileum and colon (Bottcher et al 1984) and PP, a member of the PP-fold peptide family, which also includes PYY and neuropeptide Y (NPY), is produced by endocrine type F-cells of the pancreatic islets (Adrian et al 1976). These satiety hormones seem to inhibit food intake by altering central nervous system appetite circuits, within the arcuate nucleus of the hypothalamus or area postrema (Gutzwiller et al 1999.…”

Section: Discussionmentioning

confidence: 99%

Effects of exercise on gut peptides, energy intake and appetite

Martins¹,

Bloom²,

Robertson³

2007

Journal of Endocrinology

286

284

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This study investigated the acute effects of exercise on the postprandial levels of appetite-related hormones and metabolites, energy intake (EI) and subjective measures of appetite. Ghrelin, polypeptide YY (PYY), glucagon-like peptide-1 (GLP-1) and pancreatic polypeptide (PP) were measured in the fasting state and postprandially in 12 healthy, normalweight volunteers (six males and six females) using a randomised crossover design. One hour after a standardised breakfast, subjects either cycled for 60 min at 65% of their maximal heart rate or rested. Subjective appetite was assessed throughout the study using visual analogue scales and subsequent EI at a buffet meal was measured at the end (3-h post-breakfast and 1-h post-exercise). Exercise significantly increased mean PYY, GLP-1 and PP levels, and this effect was maintained during the post-exercise period for GLP-1 and PP. No significant effect of exercise was observed on postprandial levels of ghrelin. During the exercise period, hunger scores were significantly decreased; however, this effect disappeared in the post-exercise period. Exercise significantly increased subsequent absolute EI, but produced a significant decrease in relative EI after accounting for the energy expended during exercise. Hunger scores and PYY, GLP-1 and PP levels showed an inverse temporal pattern during the 1-h exercise/control intervention. In conclusion, acute exercise, of moderate intensity, temporarily decreased hunger sensations and was able to produce a short-term negative energy balance. This impact on appetite and subsequent energy homeostasis was not explained by changes in postprandial levels of ghrelin; however, 'exercise-induced anorexia' may potentially be linked to increased PYY, GLP-1 and PP levels.

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Section: Discussionmentioning

confidence: 99%

Effects of exercise on gut peptides, energy intake and appetite

Martins¹,

Bloom²,

Robertson³

2007

Journal of Endocrinology

286

284

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“…NPY is widely distributed in the peripheral nervous system and is co-localized with noradrenaline (NA) in many sympathetic fibres (Lundberg et al, 1982b), notably around blood vessels (Uddman et al, 1985). PYY in contrast occurs mainly in endocrine cells in the gut (Lundberg et al, 1982a;Bottcher et al, 1984). NPY has been attributed a variety of functional roles (for a review see Edvinsson et al, 1987).…”

Section: Introductionmentioning

confidence: 99%

Effects of various neuropeptide Y/peptide YY fragments on electrically‐evoked contractions of the rat vas deferens

Grundemar

Håkanson

1990

British J Pharmacology

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1The effects of various neuropeptide Y (NPY) and peptide YY (PYY) fragments on electrically-evoked twitches in the rat isolated vas deferens were studied and compared with the effects of full length NPY and PYY. The aim was to identify the shortest NPY/PYY fragments that are capable of suppressing the contractions. 2 NPY (1-36) and C-terminal fragments of NPY (from 11-36 to 22-36) suppressed the electricallyevoked twitches in a concentration-dependent manner. On the whole there seemed to be a gradual lowering of the pIC50 values with progressive shortening of the NPY fragments (except for fragments 16-36 and 22-36 that had rather high pIC50 values). NPY 23-36, 24-36 and 25-36 suppressed the twitches at high concentrations (3pM). NPY 26-36 was without effect as were C-terminal carboxy-deaminated NPY and glycine extended NPY (NPY-Gly-Lys-Arg). 3 PYY (1-36) and C-terminal fragments of PYY (from 11-36 to 23-36) suppressed the electricallyevoked twitches in a concentration-dependent manner. PYY 1-36 was more potent than any of the fragments. There was a tendency for shorter fragments to have lower pIC50 values. suppressed the twitches at high concentrations (3 gM). PYY 26-36 was without effect.4 The findings suggest that the 12 C-terminal amino acid residues of NPY and PYY are the minimum length required to activate the Y2-receptor.

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“…85,88,81,94,95,91 This result may explain the improvements in the clinical and laboratorial conditions of patients with metabolic syndrome who undergo these procedures.…”

Section: After Ileal Interpositionmentioning

confidence: 83%

Structural changes in intestinal enteroendocrine cells after ileal interposition in normal rats

et al. 2011

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INTRODUCTION:No therapeutic approach has significantly impacted the progression of diabetes. As early improvement of glicaemic control is observed after bariatric surgeries, there is currently a search for surgical procedures that can promote euglycemia also in non-obese patients. Glicaemic control can be achieved by increasing the blood concentration of GLP-1, a hormone produced by L cells that are more densely concentrated in the terminal ileum. The interposition of ileal segment to a more anterior region (proximal jejunum) can promote a greater stimulation of the L cells by poorly digested food, increasing the production of GLP-1 and reflecting on glicaemic control. AIMS:To investigate long-term histological modifications of intestinal mucosa of rats submitted to interposition of ileum segment to a proximal region (jejunum). METHODS:Forty 8-week old male Wistar-EPM1 rats (Rattus norvegicus albinus) were randomly distributed into 3 groups: the Interposition Group (IG) was subjected to ileal interposition, the Sham Group (SG) was subjected to sham operations, and the Control Group (CG) was not subjected to surgery. All animals were followed until the 60 th postoperative day (8 postoperative week) when they were euthanized. Segments of jejunum and ileum from all groups were collected and analyzed by optical microscopy and immunohistochemistry. RESULTS:No structural nor histological changes in intestinal L cells in the interposed intestinal segment and other intestinal segments were noted after ileal interposition surgery. CONCLUSION:As L cells endocrine characteristics were likely maintained, the use of metabolic surgical techniques for the treatment of metabolic diseases, especially diabetes, seems to be justified.

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Coexistence of peptide YY and glicentin immunoreactivity in endocrine cells of the gut

Cited by 180 publications

References 18 publications

Effects of exercise on gut peptides, energy intake and appetite

Effects of exercise on gut peptides, energy intake and appetite

Effects of various neuropeptide Y/peptide YY fragments on electrically‐evoked contractions of the rat vas deferens

Structural changes in intestinal enteroendocrine cells after ileal interposition in normal rats

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