Coexistence of pemphigus herpetiformis with extramammary Paget disease

Wang, F. F.; Bai, Yanping; Zheng, Zhifang; Tong, Jie; Wu, Yatong

doi:10.1111/ced.13318

Cited by 1 publication

(3 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Pemphigus herpetiformis associated with neoplasia is rare (6%). Among reported cases were three patients with lung cancer; 1, esophageal carcinoma; 1, thymic tumor; 1, lymphoma; 2, prostate cancer; 1, cutaneous angiosarcoma; and 1, extramammary Paget disease . In most cases, because of the limited descriptions and variable immunologic profiles among affected patients, the correlation between PH and neoplasia was unclear.…”

Section: Resultsmentioning

confidence: 99%

“…The initial search yielded 371 publications: 284 from the PubMed database and 87 from the Ovid Medline database. We identified 96 publications (88 from PubMed and 63 from Ovid Medline [55 duplicates between the two databases]) reporting 158 individual cases that fulfilled the inclusion criteria. We also report an additional three unpublished cases diagnosed at our institution.…”

Section: Resultsmentioning

confidence: 99%

“…Among reported cases were three patients with lung cancer 66 71 ; and 1, extramammary Paget disease. 105 In most cases, because of the limited descriptions and variable immunologic profiles among affected patients, the correlation between PH and neoplasia was unclear. An apparent parallel course of PH and malignancy was reported only once in 2002, 88 when a case was described of a patient with lung cancer concomitant with PH; a diagnosis of paraneoplastic PH was proposed, which may have been meant to describe the coexistence of PH and neoplasia.…”

Section: Immunologic Findingsmentioning

confidence: 99%

See 2 more Smart Citations

Clinical, pathologic, and immunologic features of pemphigus herpetiformis: a literature review and proposed diagnostic criteria

2019

View full text Add to dashboard Cite

Pemphigus herpetiformis (PH), a rare type of pemphigus, is characterized by immunologic findings consistent with pemphigus but with a unique clinical and pathologic presentation. PH was first described as resembling dermatitis herpetiformis clinically, but because of its variable presentation, it can also resemble linear immunoglobulin A bullous dermatosis and bullous pemphigoid. We reviewed reported cases to analyze the most frequent clinical, pathologic, and immunologic characteristics and to propose corresponding diagnostic criteria. Through a comprehensive review of Medline and PubMed databases, 96 publications and 158 cases were identified. After reviewing the reported characteristics of PH, we suggest the following diagnostic criteria: Clinical: 1) pruritic herpetiform intact blisters with/without erosions; and/or 2) pruritic annular or urticarial erythematous plaques with/without erosions; Pathologic: 1) intraepidermal eosinophils or neutrophils, or both; and/or 2) intraepidermal split with/without acantholysis; Immunologic: 1) direct immunofluorescence showing immunoglobulin G with/without C3 intercellular deposits; and/or 2) indirect immunofluorescence showing immunoglobulin G to epithelial cell surface; and/or 3) detection of serum autoantibodies against desmogleins (1,3) or desmocollins (1,2,3), or both. Diagnosis requires one clinical, one pathologic, and one immunologic feature. We also report three new cases diagnosed at our institution to demonstrate the applicability of the suggested criteria.

show abstract