Coexistence of Osteopoikilosis and Discoid Lupus Erythematosus: A Case Report

Abstract

Osteopoikilosis is an uncommon, benign sclerosing bone dysplasia characterised by typical roentgenographic findings and usually seen in patients with dermatological problems. We report a case of osteopoikilosis and discoid lupus erythematosus presenting with skin and mucosal involvement, an association that has never previously been reported. We also discuss the differential diagnosis and the clinical pathologies accompanying osteopoikilosis in the literature.

Osteopoikilosis: what does the rheumatologist must know about it?

“…Occasionally, this condition is associated with renal or heart malformations or endocrine disorders [1]. Several pathologies can coexist with OPK, such as rheumatoid arthritis, systemic lupus erythematosus, reactive arthritis, ankylosing spondylitis, psoriatic arthritis, familial Mediterranean fever, dacryocystitis, scleroderma, fibromyalgia, and Quervain's syndrome [1,2,4,[12][13][14][15]. Primarily asymptomatic OPK associated with connective tissue nevi of the skin is categorized as Buschke-Ollendorff syndrome (BOS).…”

A case of osteopoikilosis coexisting with amyloidosis of familial Mediterranean fever

“…It is commonly associated with small subcutaneous fibrous nodules called dermatofibrosis lenticularis disseminate (Buschke-Ollendorff syndrome) [1,2]. However, patients with osteopoikilosis and rheumatoid arthritis, polyarthralgia, synovial chondromatosis, dacriocystitis, trisomy 8, connective tissue disorders affecting the skin and joints, and discoid lupus erythematosus have also been reported [3,4,5,6,7,8,9]. Here we report a pediatric renal transplant recipient with amyloidosis secondary to familial Mediterranean fever (FMF) who was incidentally diagnosed as having osteopoikilosis in the 6th post-transplant year.…”

Osteopoikilosis associated with keloids formation, rheumatoid arthritis, myasthenia, Graves` disease and megaloblastic anaemia

“…Reports have described cases of concurrent OPK and RA [9][10][11], as well as comorbidity involving RA and symptoms of Sjögren's syndrome [12], systemic lupus erythematosus [13], and discoid lupus erythematosus [14]. Osteopoikilosis is known to occur in association with symptoms of systemic sclerosis [15,16], keloid formation [7,16], and with seronegative spondyloartropathy [17,18].…”

“…Opisywano równoczesne występowanie OPK i RZS [9][10][11], a także RZS skojarzonego z objawami zespołu Sjögrena [12], tocznia rumieniowatego układowego [13] i tocznia rumieniowatego krążkowego [14]. Osteopoikilia łączyła się z objawami twardziny układowej [15,16], powstawaniem bliznowców [7,16] oraz ze spondyloartropatiami seronegatywnymi [17,18].…”