Coexistence of nasal reactivity to allergens with and without IgE sensitization in patients with allergic rhinitis

Eguiluz‐Gracia, Ibon; Fernandez, Tahía D.; Testera‐Montes, Almudena; Ariza, Adriana; Campo, Paloma; Prieto, Ana; Pérez‐Sánchez, Natalia; Salas, María; Mayorga, Cristobalina; Torres, Marı́a José; Rondón, Carmen

doi:10.1111/all.14206

Cited by 38 publications

(69 citation statements)

References 44 publications

(129 reference statements)

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“…For these patients, BAT displays 100% positivity with seasonal allergens and 60% positivity with perennial allergens. 101 Overall, NAC can act as a gold standard in distinguishing the AR phenotype. And BAT could also be useful as an in vitro tool for LAR/ DAR diagnosis in the daily practice.…”

Section: Clinical Biomarkers Of Allergic Rhinitismentioning

confidence: 99%

Biomarkers for diagnosis and prediction of therapy responses in allergic diseases and asthma

Breiteneder

Peng

Agache

et al. 2020

Allergy

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161

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Section: Clinical Biomarkers Of Allergic Rhinitismentioning

confidence: 99%

Biomarkers for diagnosis and prediction of therapy responses in allergic diseases and asthma

Breiteneder

Peng

Agache

et al. 2020

Allergy

Self Cite

161

150

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“…In this regard, outdoor allergens, such as grass and tree pollens, are normally the main sensitizing allergens for SAR, whereas indoor allergens, such as dust mite allergens are the sensitizing allergens for PAR. 1,2 Recent studies have found different allergens to be prevalent in different regions. For example, birch and grass pollen are the two most common allergens in Denmark, 3 Japanese cedar pollen (JC) is most common in Japan, 4,5 and artemisia pollen is the main allergen in northern China.…”

Section: Environmental Fac Tor Smentioning

confidence: 99%

“…14 Sometimes, environmental factors may not only induce AR, but may also aggravate AR. 2 In particular, an increase in air pollutants in the environment has been found to be associated with increased incidence of allergic respiratory diseases 15 ; with one study in children demonstrating that exposure to oxidizing pollutants in the air leads to a higher risk of developing AR in these children. 16 There is evidence that exposure to the particulate matter (PM2.5) in the environment may increase the degree of DNA methylation in the body.…”

Section: Environmental Fac Tor Smentioning

confidence: 99%

Advances and novel developments in allergic rhinitis

Meng

Wang

Zhang

2020

Allergy

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Allergic rhinitis (AR) is an upper airway disease with high prevalence in the world, and therefore needs to be thoroughly investigated and treated accordingly. Although the mechanisms underlying the pathology and treatment of AR have been widely studied, many aspects of AR are still unclear and warrant further investigations. The purpose of the present review was therefore to report recently published papers, which highlight the novel mechanisms and treatments of AR. These include role of environment, important proteins and cells, and some other factors in the pathogenesis of AR; as well as the role of immunotherapy and biologics in the treatment of AR.

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“…It is noteworthy that a proportion of patients displaying nasal reactivity do not exhibit systemic sensitization evidenced by negative skin prick tests (SPT) and undetectable serum-specific IgE (sIgE), an endotype consequently defined as local AR (LAR) [14,15]. Recent evidence shows that both sensitization patterns in response to different allergens can coexist within the same individual, the proposed term for which is dual AR (DAR) [16].…”

Section: Introductionmentioning

confidence: 99%

Mechanisms of Allergen Immunotherapy in Allergic Rhinitis

Drazdauskaité

Layhadi

Shamji

2020

Curr Allergy Asthma Rep

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Purpose of Review Allergic rhinitis (AR) is a chronic inflammatory immunoglobulin (Ig) E-mediated disease of the nasal mucosa that can be triggered by the inhalation of seasonal or perennial allergens. Typical symptoms include sneezing, rhinorrhea, nasal itching, nasal congestion and symptoms of allergic conjunctivitis. AR affects a quarter of the population in the United States of America and Europe. Recent Findings AR has been shown to reduce work productivity in 36–59% of the patients with 20% reporting deteriorated job attendance. Moreover, 42% of children with AR report reduced at-school productivity and lower grades. Most importantly, AR impacts the patient’s quality of life, due to sleep deprivation. However, a proportion of patients fails to respond to conventional medication and opts for the allergen immunotherapy (AIT), which currently is the only disease-modifying therapeutic option. AIT can be administered by either subcutaneous (SCIT) or sublingual (SLIT) route. Both routes of administration are safe, effective, and can lead to tolerance lasting years after treatment cessation. Both innate and adaptive immune responses that contribute to allergic inflammation are suppressed by AIT. Innate responses are ameliorated by reducing local mast cell, basophil, eosinophil, and circulating group 2 innate lymphoid cell frequencies which is accompanied by decreased basophil sensitivity. Induction of allergen-specific blocking antibodies, immunosuppressive cytokines, and regulatory T and B cell phenotypes are key pro-tolerogenic adaptive immune responses. Conclusion A comprehensive understanding of these mechanisms is necessary for optimal selection of AIT-responsive patients and monitoring treatment efficacy. Moreover, it could inspire novel and more efficient AIT approaches.

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Coexistence of nasal reactivity to allergens with and without IgE sensitization in patients with allergic rhinitis

Abstract: Ibon Eguiluz-Gracia, Ruben Fernandez-Santamaria and Almudena Testera-Montes contributed equally to this work. Clinical Implications: Nasal reactivity to aeroallergens with and without systemic IgE sensitization can coexist in the same rhinitis patient.

Cited by 38 publications

References 44 publications

Biomarkers for diagnosis and prediction of therapy responses in allergic diseases and asthma

Biomarkers for diagnosis and prediction of therapy responses in allergic diseases and asthma

Advances and novel developments in allergic rhinitis

Mechanisms of Allergen Immunotherapy in Allergic Rhinitis

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