Coexistence of muscarinic acetylcholine receptors and somatostatin in nonpyramidal neurons of the rat dorsal hippocampus

Zee, van der Eddy; Benoit, Robert; Strosberg, A. Donny; Luiten, P.G.M.

doi:10.1016/0361-9230(91)90005-5

Cited by 25 publications

(5 citation statements)

References 52 publications

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“…Therefore, M35 immunoreactivity (ir) allows visualization of phosphorylated/internalilzed mAChRs and can be used as a tool to investigate the functional cholinergic properties of a cell or network. Immuncytochemical studies in naïve animals have found M35-ir in basket cells within stratum pyramidale of CA1-CA3 as well as other interneuron types in SLM and stratum oriens/alveus (Van der Zee et al, 1989, 1991a). Similar studies found a high degree of colocalization between M35 and the GABA markers PV and SOM (Van der Zee et al, 1991a,b, 1993).…”

Section: Cholinergic Modulation Of Interneuronsmentioning

confidence: 99%

“…Immuncytochemical studies in naïve animals have found M35-ir in basket cells within stratum pyramidale of CA1-CA3 as well as other interneuron types in SLM and stratum oriens/alveus (Van der Zee et al, 1989, 1991a). Similar studies found a high degree of colocalization between M35 and the GABA markers PV and SOM (Van der Zee et al, 1991a,b, 1993). Out of 2730 hippocampal interneurons expressing mAChRs, 33% colocalized with SOM, 52% with PV, and 72.8% with SOM and/or PV.…”

Section: Cholinergic Modulation Of Interneuronsmentioning

confidence: 99%

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Effects of acetylcholine on neuronal properties in entorhinal cortex

Heys¹,

Schultheiss²,

Shay³

et al. 2012

Front. Behav. Neurosci.

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The entorhinal cortex (EC) receives prominent cholinergic innervation from the medial septum and the vertical limb of the diagonal band of Broca (MSDB). To understand how cholinergic neurotransmission can modulate behavior, research has been directed toward identification of the specific cellular mechanisms in EC that can be modulated through cholinergic activity. This review focuses on intrinsic cellular properties of neurons in EC that may underlie functions such as working memory, spatial processing, and episodic memory. In particular, the study of stellate cells (SCs) in medial entorhinal has resulted in discovery of correlations between physiological properties of these neurons and properties of the unique spatial representation that is demonstrated through unit recordings of neurons in medial entorhinal cortex (mEC) from awake-behaving animals. A separate line of investigation has demonstrated persistent firing behavior among neurons in EC that is enhanced by cholinergic activity and could underlie working memory. There is also evidence that acetylcholine plays a role in modulation of synaptic transmission that could also enhance mnemonic function in EC. Finally, the local circuits of EC demonstrate a variety of interneuron physiology, which is also subject to cholinergic modulation. Together these effects alter the dynamics of EC to underlie the functional role of acetylcholine in memory.

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Section: Cholinergic Modulation Of Interneuronsmentioning

confidence: 99%

Section: Cholinergic Modulation Of Interneuronsmentioning

confidence: 99%

Effects of acetylcholine on neuronal properties in entorhinal cortex

Heys¹,

Schultheiss²,

Shay³

et al. 2012

Front. Behav. Neurosci.

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“…PKCr appeared to be highly expressed in neurons possessing mAChRs (Van der Zee et al, 1990). Currently, we are examining changes in mAChR characteristics induced by spatial discrimination learning in mouse hippocampus by means of the anti-mAChR antibody M35 (Van der Zee et al, 1989Zee et al, , 1991. The glutamatergic entorhinal projection to the hippocampus terminates on hippocampal (CAl) pyramidal cell-quantitative changes in spine density followinn handling, and iniection for drug testing.…”

Section: Changes In 36g9-ir After In Vitro Manipulation Of Pkc By Cofmentioning

confidence: 99%

“…Protein kinase C (PKC) is a key enzyme for signal transduction and various neuronal plasticity mechanisms, and can be activated by receptor-stimulated turnover of phosphoinositides (Nishizuka, 1986(Nishizuka, , 1988Strosberg, 1991). Rat brain PKC consists of seven distinct isoforms, each with a characteristic distribution within the CNS (K.-P. Huang et al, 1986;Kikkawa et al, 1987;F.…”

mentioning

confidence: 99%

Changes in PKC gamma immunoreactivity in mouse hippocampus induced by spatial discrimination learning

et al. 1992

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In the present study, we examined changes in immunoreactivity (ir) for the gamma-isoform of protein kinase C (PKC gamma) in mouse hippocampus in relation to spatial memory processes employing the monoclonal antibody 36G9 raised against purified PKC gamma. Learning and memory were assessed by performance in a free-choice spatial pattern paradigm in a hole board in which the animals learned the pattern of 4 baited holes out of 16 holes. Adult male house mice were used, divided in four groups. Three control groups were formed: group N, naive (blank controls); group H, habituated (animals were for 5 consecutive days introduced to the hole board with all holes baited); and group PT, pseudotrained (animals were for 13 consecutive days introduced to the hole board with all holes baited). The T (trained) group was for 5 consecutive days introduced to the hole board with all holes baited (similar to the H and PT groups) followed by 8 successive days with only four holes baited in a fixed pattern. Behaviorally, following the first 5 d, the PT group crossed the hole board randomly, whereas the T group gradually learned to orientate in the hole board. The mice were killed 24 hr after the last performance. A shift in 36G9-ir appeared from the cell somata to the dendrites of hippocampal principal neurons when comparing the H and PT group, respectively. In contrast, the T group showed strong PKC gamma-ir in both cell somata and dendrites, which clearly exceeded that of the H and PT mice. In this way, 36G9-ir reveals the physiologically activated neurons involved in hole board learning.(ABSTRACT TRUNCATED AT 250 WORDS)

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“…The mean frequency of most neurons did not change significantly, though some tendency for activity to decrease, which is also seen on decoupling of the hippocampus and septum, could be observed [1]. This is in agreement with the existence of theta modulation in the activity of these cells and with data indicating that they have a high concentration of cholinergic septal synapses [26,45]. We have previously analyzed the unreliability of discriminating functionally different neurons (pyramidal and inhibitory cells) by extracellular recordings in rabbits [3], though if it is assumed that high-frequency cells are inhibitory neurons, this it follows that these may receive tonic excitatory influences from the MS-DT.…”

Section: Discussionmentioning

confidence: 99%

Background activity of rabbit hippocampal neurons in conditions of functional exclusion of structures which regulate the theta rhythm

Kichigina

Kudina²,

Zenchenko³

et al. 1999

Neurosci Behav Physiol

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The functional importance of theta modulation in the activity of hippocampal neurons was further analyzed using a method consisting of controlled sequential short-term (25-30 min) inclusion or exclusion of the theta rhythm by local administration of lidocaine into the median cervical nucleus and medial septal region respectively. Studies were carried out using conscious rabbits with extracellular recording of hippocampal neuron activity in field CA1. Administration of lidocaine into the medial septal nucleus and diagonal tract nucleus (MS-DT) led to complete inhibition of theta modulation in neuronal and total hippocampus activity. The mean frequency of background discharges underwent no change in most neurons, but decreased significantly in a limited group of cells with high-frequency activity (presumptive inhibitory neurons). Administration of lidocaine into the median cervical nucleus (MCN), the source of serotoninergic pathways to the MS-DT and hippocampus, was accompanied by increases in the stability and frequency of theta modulation of neuronal activity, induction of theta modulation in an additional group of neurons, and expression of a continuous theta rhythm in the electrical activity (EA) of the hippocampus. The mean frequency and regularity of discharges increased in most cells. These data support the existence of tonic inhibitory effects on the part of the MCN on the septa-hippocampal system generating the theta rhythm; in this regard, the MCN can be regarded as an antagonist of the activating reticular formation.

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Coexistence of muscarinic acetylcholine receptors and somatostatin in nonpyramidal neurons of the rat dorsal hippocampus

Cited by 25 publications

References 52 publications

Effects of acetylcholine on neuronal properties in entorhinal cortex

Effects of acetylcholine on neuronal properties in entorhinal cortex

Changes in PKC gamma immunoreactivity in mouse hippocampus induced by spatial discrimination learning

Background activity of rabbit hippocampal neurons in conditions of functional exclusion of structures which regulate the theta rhythm

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