Coexistence of mucous membrane pemphigoid, vitiligo, and hypothyroidism: A second report of a new multiple autoimmune syndrome

Niknezhad, Nasim; Ghalamkarpour, Fariba; Niknejad, Nakisa; Asadi-Kani, Zahra

doi:10.1111/dth.12717

Cited by 4 publications

(4 citation statements)

References 5 publications

(3 reference statements)

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“…Comorbidity of OCP with other ADs, such as Rheumatoid Arthritis and Pernicious anemia, has been described. 5,6 In the same way, Nayar et al 6 reported that 11/34 patients of OCP population presented polyautoimmunity. The most common OCP association was pernicious anemia, followed by vitiligo and polymyalgia rheumatica.…”

Section: Discussionmentioning

confidence: 81%

“…Contrarily, other case reports have described the appearance of OCP as the last manifestation of the syndrome, after vitiligo and AITD. 5 Hence, our patient’s disease association and presentation could be considered uncommon.…”

Section: Discussionmentioning

confidence: 85%

“… 4 Some studies have described a clinical association between MMP, vitiligo, and Hashimoto’s Thyroiditis (HT). 5 Other related ADs associated to MMP such as Rheumatoid Arthritis and Polymyalgia Rheumatica have been described as well. 6 In the same way, polyautoimmunity has been described in 32% of patients with OCP, being pernicious anemia the most frequently related disease.…”

Section: Introductionmentioning

confidence: 99%

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Ocular Cicatricial Pemphigoid, Sjögren’s Syndrome, and Hashimoto’s Thyroiditis as a Multiple Autoimmune Syndrome: A case report

Cifuentes-González

Amaris-Martínez

Reyes-Guanes

et al. 2021

European Journal of Ophthalmology

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Purpose: To present a rare and novel association of Ocular Cicatricial Pemphigoid, Sjögren’s Syndrome, and Hashimoto’s Thyroiditis as a Multiple Autoimmune Syndrome. Case report: A 43-year-old Colombian female, presented with corneal ulcers, associated with trichiasis. At the ophthalmological examination forniceal shortening OU and symblepharon OD was found. Conjunctival biopsy was performed, evidencing linear deposition of IgG and IgA antibodies along the basement membrane of the conjunctiva, confirming Ocular Cicatricial Pemphigoid diagnosis. After 12 years, the patient presented constitutional symptoms, xerostomia, and worsening of xerophthalmia. Laboratory tests showed positive Anti-TG, Anti-TPO, Anti-Ro, and Anti-La antibodies, and salivary gland biopsy was consistent with Sjögren’s Syndrome. Due to these findings, Hashimoto’s Thyroiditis and Sjögren’s Syndrome were diagnosed, defining a Multiple Autoimmune Syndrome. Conclusion: A novel association of Multiple Autoimmune Syndrome is presented in this case. Ophthalmologists and other specialists involved in the evaluation and treatment of patients with autoimmune diseases, should be aware of this clinical presentation. A multidisciplinary approach in this condition is important for optimum treatment instauration and follow-up, in order to prevent complications.

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Section: Discussionmentioning

confidence: 81%

Section: Discussionmentioning

confidence: 85%

Section: Introductionmentioning

confidence: 99%

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Ocular Cicatricial Pemphigoid, Sjögren’s Syndrome, and Hashimoto’s Thyroiditis as a Multiple Autoimmune Syndrome: A case report

Cifuentes-González

Amaris-Martínez

Reyes-Guanes

et al. 2021

European Journal of Ophthalmology

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“…Different autoimmune disorders occurring in the same individual is called multiple autoimmune syndrome (MAS) which is seen in approximately 25% of individuals with a single autoimmune disease [1] . The most frequent autoimmune diseases in such patients include dermatological conditions like alopecia areata or vitiligo [2] . The main aetiology of MAS is unclear, but a combination of genetic susceptibility and environmental triggers may be involved [3] .…”

Section: Introductionmentioning

confidence: 99%

Autoimmune Haemolytic Anaemia and Multiple Autoimmune Syndrome

Sereshki

Almasi

Behnam

et al. 2019

European Journal of Case Reports in Internal Medicine

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The presence of different autoimmune disorders in the same individual is called multiple autoimmune syndrome (MAS). One of these co-occurring conditions is autoimmune haemolytic anaemia (AIHA), which is characterized by the production of autoantibodies against red blood cells due to immune system malfunction and which results in severe tissue oxygenation disturbance. AIHA is not uncommon but occurs rarely in MAS; if it does, MAS is then classified as MAS type III. Herein, we describe a case of MAS type III including AIHA which was successfully treated with hydrocortisone with gradual resolution of symptoms. LEARNING POINTS The co-occurrence of multiple autoimmune disorders in the same individual is called multiple autoimmune syndrome (MAS). Autoimmune haemolytic anaemia is not uncommon but rarely occurs in MAS. The presence of one autoimmune disease should alert the physician to the possible presence of others.

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The diagnostic difficulties of juvenile vulvar pemphigoid

Gart,

Swali,

Lee

et al. 2024

Pediatric Dermatology

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Mucous membrane pemphigoid is a rare autoimmune disease affecting mucosal surfaces. Pediatric cases are exceptionally rare, one subtype being vulvar pemphigoid. Juvenile vulvar pemphigoid can be challenging to diagnose due to its rarity and subtle initial symptoms. We present a case of an 8‐year‐old girl successfully diagnosed early in the disease course via histopathology, and immunofluorescence. Detecting MMP can be complex due to variations in epitope binding typically not included in commercial ELISA assays, necessitating comprehensive workup. Missed diagnosis may lead to progression to systemic involvement with severe consequences; thus, timely diagnosis and treatment are crucial.

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Coexistence of mucous membrane pemphigoid, vitiligo, and hypothyroidism: A second report of a new multiple autoimmune syndrome

Cited by 4 publications

References 5 publications

Ocular Cicatricial Pemphigoid, Sjögren’s Syndrome, and Hashimoto’s Thyroiditis as a Multiple Autoimmune Syndrome: A case report

Ocular Cicatricial Pemphigoid, Sjögren’s Syndrome, and Hashimoto’s Thyroiditis as a Multiple Autoimmune Syndrome: A case report

Autoimmune Haemolytic Anaemia and Multiple Autoimmune Syndrome

The diagnostic difficulties of juvenile vulvar pemphigoid

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