Coexistence of marginal zone cutaneous B-cell lymphoma and classic Hodgkin disease: does a biological relationship exist?

Abstract

The coexistence of non-Hodgkin lymphoma (NHL) and Hodgkin disease (HD) in the same patient, although previously reported, is very unusual. This situation is extremely rare when the first diagnosis is a cutaneous B NHL, and exceptional if there is no personal background of cytostatic treatment. We report a 44-year-old man who developed cutaneous nodules over a period of two years. A marginal zone cutaneous B-cell lymphoma was diagnosed. On staging investigation a mass in the lingual tonsil was found and excision biopsy showed a classical Hodgkin lymphoma.

Expert consensus statements for Waldeyer's ring involvement in pediatric Hodgkin lymphoma: The staging, evaluation, and response criteria harmonization (SEARCH) for childhood, adolescent, and young adult Hodgkin lymphoma (CAYAHL) group

“…There were no clinical trials identified that outlined any specific staging or response assessment criteria for WR. The entire systematic review described 166 unique cases of WR involvement in patients with HL (Table S1) 7‐30,32,37‐49 . Seven pediatric cases were identified, of which six were male patients 12,13,31,38,42,44,46 .…”

“…Seven pediatric cases were identified, of which six were male patients 12,13,31,38,42,44,46 . Although stage was not specified for all of the pediatric cases, at least two cases were isolated to WR alone, 13,31 and several cases in adults were isolated to WR 7,18,21,24,28,39,40,41,43,45,49 . Common clinical presentations for WR involvement included nasal obstruction or congestion, hoarseness, and painless tonsillar swelling.…”

“…Historically, diagnosis of WR involvement was limited to direct observation through physical exam or nasopharyngoscopy, with or without the use of biopsy 8‐11 . As imaging advancements have progressed, the use of computed tomography (CT) and magnetic resonance imaging (MRI) is increasingly more common 12‐25 . In the era of fluoro‐2‐deoxy‐ d ‐glucose positron emission tomography (FDG‐PET), more accurate diagnosis is possible, but new challenges have arisen especially in pediatric patients who frequently demonstrate a physiologic increase in FDG‐PET avidity in some areas of WR, particularly the adenoids and palatine tonsils 26‐29 .…”

Paediatric primary cutaneous marginal zone B-cell lymphoma: does it differ from its adult counterpart?

“…One of our patients was diagnosed with Hodgkin lymphoma 8 years after the diagnosis of PCMZL. An association of PCMZL with Hodgkin lymphoma has rarely been reported …”

Unusual Case of Subcutaneous Nodules With Endobronchial Lesions in a Patient With Retroviral Infection: Disseminated Cutaneous Lymphoma: Case Report

“…Cutaneous lymphomas represent a unique group of lymphomas and are the second most frequent extranodal lymphomas. 1,2 Cutaneous lymphomas are identified by lymphoproliferative skin infiltrates of T-cell, B-cell, or natural killer cell lineage, and seen confined to the skin with paucity of extracutaneous manifestations.…”