Coexistence of Hydroa Vacciniforme and Malignant Lymphoma

Oono, Takashi; Arata, Jirô; Masuda, Toshiki; Ohtsuki, Yuji

doi:10.1001/archderm.1986.01660230098020

Cited by 67 publications

(31 citation statements)

References 9 publications

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“…As EBV has been considered to be monoclonal on the basis of several repeated analyses in HVLL, we considered EBERpositive cells to be the neoplastic ones. 2,10,23,36,43,48,53,54,64 …”

Section: In Situ Hybridization For Ebv-encoded Rnamentioning

confidence: 99%

“…15,16,31,64 EBV has been considered to be monoclonal on the basis of several repeated analyses in HVLL, and expresses a type II latency of EBV infection, with EBER expressed in all cases. 2,10,23,36,43,48,53,54,64 HV symptoms are associated in some of these patients with hypersensitivity to mosquito bites (HMB), 13,17,22,24,63 which is an EBV-related disease exclusively reported in restricted areas such as Asia and Mexico, and characterized by an indurate, clear, or hemorrhagic bulla at the mosquito bite site that develops into necrosis or an ulcer, and heals with residual scarring. In contrast to HV, HMB frequently presents with high fever and general malaise and lymphadenopathy, hepatosplenomegaly, and even renal failure.…”

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confidence: 99%

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EBV-associated Cutaneous NK/T-cell Lymphoma

Rodríguez‐Pinilla¹,

Barrionuevo²,

Garcı́a

et al. 2010

American Journal of Surgical Pathology

104

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We have reviewed clinically, morphologically, and immunophenotypically a series of 14 Epstein-Bar virus (EBV)+ cutaneous natural killer cell (NK)/T-cell lymphoma from Peru. Most (11 out of 14) of these cases fit well into the category of Hydroa vacciniforme-like lymphoma (HVLL), but 3 have a different clinical presentation, without facial involvement. In all 14 cases, skin lesions present in both the sun-exposed and nonexposed areas exhibited a slowly progressive relapsing course, changing from edema, to blistering, ulceration, and final scarring. The immunophenotype had a cytotoxic T or NK-cell lineage. The mean time of disease before admission to hospital was 69 months (range, 6 mo to 31 y). Only 2 patients had fever, hepatosplenomegaly, systemic lymphadenopathy, and a high lactate dehydrodenage (LDH) level at the time of diagnosis, whereas 10 had facial swelling. After treatment, only 4 patients remain alive, although with persistent disease. Ten patients died after a mean follow-up of 11.6 months after the initial diagnosis (range, 1 to 32 mo), because of concurrent infections (4 cases), disease progression (4 patients) or both (2 patients). Endemic Epstein-Bar virus (EBV)-positive cutaneous NK/T-cell lymphoproliferative disorders in childhood and early adulthood are characterized by a protracted clinical course, eventually leading to an aggressive phase characterized by concurrent infections and disease progression.

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“…As EBV has been considered to be monoclonal on the basis of several repeated analyses in HVLL, we considered EBERpositive cells to be the neoplastic ones. 2,10,23,36,43,48,53,54,64 …”

Section: In Situ Hybridization For Ebv-encoded Rnamentioning

confidence: 99%

mentioning

confidence: 99%

EBV-associated Cutaneous NK/T-cell Lymphoma

Rodríguez‐Pinilla¹,

Barrionuevo²,

Garcı́a

et al. 2010

American Journal of Surgical Pathology

104

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“…So the latest edition of WHO classification grouped it as one of major types of EBV-positive T-cell lymphoproliferative disorders of childhood, and suggested "HV-like lymphoma" could be a more appropriate classification and descriptive term. 1 We have reviewed HV-like lymphoma reported in the English literature in recent 2 decades [2][3][4][5]8,[10][11][12][13][14] (Table 1). It revealed that all patients were from Asia and South America, especially Korea, Japan, China, and Mexico.…”

Section: Discussionmentioning

confidence: 99%

Primary Cutaneous Hydroa Vacciniforme–Like Lymphoma With Indolent Clinical Course

et al. 2012

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Primary cutaneous hydroa vacciniforme (HV)-like lymphoma is a rare, Epstein-Barr virus-associated cutaneous neoplasm characterized by photosensitive papulovesicular eruption and usually associated with poor prognosis. This report presents 2 cases of primary cutaneous HV-like lymphoma with unusual indolent clinical course and favorable prognosis during the follow-up periods of 2 and 3 years, respectively. Both patients presented with erythema, papulovesicles, scars, ulcerations, and edema on the face and extremities. Skin biopsies revealed epidermal vesicle with small- to medium-sized atypical lymphoid cells infiltrating in the dermis and subcutis. The lymphoid cells were strongly immunoreactive to CD8 and CD56. The Epstein-Barr virus genomes were also found in both skin biopsies. By genetic analysis, one of patients showed T-cell receptor-γ gene clonal rearrangement. The patients underwent glucocorticoid treatment and obtained remarkable clinical improvement with regression of skin lesions. No sign of recurrence and extracutaneous manifestation was found during the period of follow-up. A long-term follow-up is suggested to be performed to inspect the progression for this tumor.

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“…In the recent years, there have been a growing number of reported cases in Asia and Latin America of HV-like eruptions in patients, predominantly children, with malignant lymphoma and leukaemia 1. Most patients with HV-like eruptions and EBV in skin lymphocytes do not develop malignancy, suggesting that the classic HV and atypical HV are part of a spectrum and that the ultimate development of malignancy is related to the total number of EBV-positive cells.…”

Section: Commentmentioning

confidence: 99%

“…There are a growing number of patients with hydroa vacciniforme-like (HV) lesions who are found to have malignant lymphoma 1. To our knowledge, only two reports in the literature exist of patients with CD8-positive T cell lymphoma who have HV-like lesions, and none in the ophthalmic literature of the ocular histopathological findings2 3 in this disease.…”

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confidence: 99%