Coexistence of hepatitis B surface antigen and anti-HBs in Chinese chronic hepatitis B virus patients relating to genotype C and mutations in the S and P gene reverse transcriptase region

Liu, Weiwei; Hu, Tingting; Wang, Xinyu; Chen, Yuming; Huang, Ming; Yuan, Chao; Guan, Ming

doi:10.1007/s00705-011-1215-5

Cited by 32 publications

(65 citation statements)

References 25 publications

(51 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Therefore, routine screening for HBV in schizophrenia patients is advocated, and HBV as well as hepatitis A immunization is recommended. In this study, 38.1% of HBsAg-positive patients showed coexistence of HBsAb, which was significantly higher than previously reported results of 3%-10% [22][23][24][25][26]. The coexistence of HBsAg and antiHBs was regarded simply as superinfection with a different subtype of HBV [27].…”

Section: Discussioncontrasting

confidence: 62%

Seroepidemiology of hepatitis B virus infection among Chinese schizophrenia patients

Zhu

Liu

Xue

et al. 2015

J Infect Dev Ctries

View full text Add to dashboard Cite

Introduction: This study aimed to analyze the characteristics of HBsAg, HBsAb, coexistence of HBsAg and HBsAb, and the genotypic distribution of HBV in Chinese schizophrenia patients. Methodology: A total of 1,694 schizophrenia patients, 9-85 years of age, were recruited for the present study. HBsAg, HBsAb, and HBV DNA were detected with commercial methods. ALT, AST, γ-GT, TBIL, and IBIL were measured by an automatic biochemistry analyzer. All statistical analyses were performed with SPSS 13.0. Results: The seroprevalence of HBsAg and HBsAb in 1,649 schizophrenia patients was 11.0% and 54.6%, respectively. HBsAb seroprevalence significantly decreased with the duration of the disease (p = 0.0009). The lowest seroprevalence of HBsAg was determined in 9.4% of the patients who had had the illness for < 1 year, and then increased to 11.7%, 11.3% and 11.7% in the patients who had had the illness for 1-5 years, 6-10 years and > 10 years. HBsAg and HBsAb coexisted in 69 individuals, which comprised 4.2% of the total subjects, and in 38.1% of the HBsAg-positive patients. Additionally, HBV titers were quantified in 64 HBsAg-positive samples; the highest virus titer was 6.14×10 8 copies/mL, while 12 patients had less than 500 copies/mL. Moreover, among 48 HBV strains isolated from 62 HBsAg-positive samples, 33 and 15 strains belonged to genotypes C and B, respectively. Conclusion: Genotypes B and C HBV were the dominant genotypes distributed in schizophrenia patients, and the HBsAb seroprevalence significantly decreased with illness duration. Effective prevention strategies for against HBV transmission are required.

show abstract

Section: Discussioncontrasting

confidence: 62%

Seroepidemiology of hepatitis B virus infection among Chinese schizophrenia patients

Zhu

Liu

Xue

et al. 2015

J Infect Dev Ctries

View full text Add to dashboard Cite

show abstract

“…This was supported by the observation that coexistence of HBsAg and anti-HBs is correlated with increased nucleotide variability in key areas of the HBV genome (Chen et al, 2011). Current studies also indicated that the serological profile of these patients showed minimal HBV replication and active CHB despite the presence of anti-HBs at a protective level (Colson et al, 2007;Liu et al, 2012). Therefore, we did not investigate the relationship between the HBsAg+/ anti-HBs+ serological profiles and HBV replication in this study.…”

Section: Discussionmentioning

confidence: 78%

“…Further genotyping assays demonstrated that subgenotype C2 (108, 33.3%) was predominantly expressed in CHB patients positive for both HBsAg and anti-HBs. It has been reported that genotype C is the predominant HBV strains in Chinese HBsAg+/antiHBs+ patients (Liu et al, 2012). Moreover, the presence of genotype C has been suggested as an independent predictive factor of elevated ALT, which corresponds to liver damage and HBV reactivation (Chu and Liaw, 2007a).…”

Section: Discussionmentioning

confidence: 99%

A large-scale analysis study on the clinical and viral characteristics of hepatitis B infection with concurrence of hepatitis B surface or E antigens and their corresponding antibodies

Xiang¹,

Chen²,

Xia

et al. 2017

Genet. Mol. Res.

View full text Add to dashboard Cite

ABSTRACT. Concurrent detection of hepatitis B surface antigen (HBsAg) and anti-HBs antibody or hepatitis B surface E antigen (HBeAg) and anti-HBe antibody in patients with chronic hepatitis B (CHB) infection is well established. However, the clinical implications of these proteins remain largely unknown. In this study, demographic, clinical, and laboratory data from 124,865 patients with chronic CHB infection were analyzed. Viral genotypes were determined by nested polymerase chain reaction. A chemiluminescent assay was applied to measure HBsAg, HBsAb, HBeAg, HBeAb, and HBcAb in sera. Among 124,865 patients with CHB infection, 324 (0.3%) were concurrently positive for HBsAg and anti-HBs, and 206 (0.2%) were concurrently positive for HBeAg and anti-HBe. The HBeAg+/anti-HBe+ group was composed of younger patients (P < 0.05). Subgenotype B2 was prevalent in HBV patients concurrently positive for HBeAg and anti-HBe, while HBV patients positive for both HBsAg and anti-HBs exhibited the C2 subgenotype. Among 530 concurrent patients, 126 (39%) HBsAg+/ anti-HBs+ patients were in the low-replication phase, and 62 (19%) were in the reactivation phase; 87 (42%) HBeAg+/anti-HBe+, and 19 (6%) HBsAg+/anti-HBs+ patients were in the immune clearance phase. In this large-scale analysis, the clinical and viral characteristics of HBV infections with concurrent HBs Ag/antibody or HBe Ag/antibody presentations have been examined, and the results may contribute to the diagnosis and treatment of CHB patients.

show abstract

“…The MHR, situated in a central region of the S gene, has been recognized as an important genetic element associated with virus infection issues, such as vaccine escape, failure of anti-viral treatment, and progress of chronic infection [19][20][21]. Chang et al reported that the rate of HBV S gene mutants in HBV DNA positive children increased gradually from 7.8% before the vaccination program to 19.6%, 28.1%, and 23.1% at 5, 10, and 15 years, respectively, after the start of the vaccination program in Taiwan [22].…”

Section: Discussionmentioning

confidence: 99%

Serologic and molecular characteristics of hepatitis B virus infection in vaccinated schizophrenia patients in China

Wang

Yu²,

Zhou³

et al. 2016

J Infect Dev Ctries

View full text Add to dashboard Cite

Introduction: Previous studies have indicated that the patients with psychiatric illness were at higher risk of hepatitis B virus (HBV) infection. However, the efficacy of hepatitis B vaccine in schizophrenia patients remains unclear. Methodology: Between June 2014 and January 2015, 415 schizophrenia patients and 3,038 controls who had been routinely immunized as infants were recruited in the present study. Hepatitis B surface antigen (HBsAg), HBsAb, and HBV DNA were detected with commercial methods according to the manufacturer's protocol. A 600-bp region of the S gene (region nt236-nt835) was amplified by nested polymerase chain reaction (PCR). The genotypes of isolated HBV were identified using phylogenetic analysis by the neighbor-joining algorithm in the software MEGA version 4.1. Results: The seroprevalence of HBsAg in schizophrenia patients was 6.75%, which was significantly higher than 3.32% measured in controls. HBsAg prevalence was 7.94% in male schizophrenia patients and 5.47% in female schizophrenia patients, while it was only 4.04% in males and 2.08% in females in the control group. The HBsAb seroprevalence rate was 58.31% in schizophrenia patients and 59.94% in nonschizophrenia controls. Moreover, one HBV strain in the schizophrenia group presented I126S vaccine escape mutation (5.88%), while three HBV isolates showed Q129H, M133L, and G145R vaccine escape mutations in the control group (6.81%). Conclusions: Schizophrenia patients are at higher risk for HBV infection, even those who had received routine immunization. Therefore, a booster HB vaccination targeted at schizophrenia patients should be considered in the future.

show abstract

Coexistence of hepatitis B surface antigen and anti-HBs in Chinese chronic hepatitis B virus patients relating to genotype C and mutations in the S and P gene reverse transcriptase region

Cited by 32 publications

References 25 publications

Seroepidemiology of hepatitis B virus infection among Chinese schizophrenia patients

Seroepidemiology of hepatitis B virus infection among Chinese schizophrenia patients

A large-scale analysis study on the clinical and viral characteristics of hepatitis B infection with concurrence of hepatitis B surface or E antigens and their corresponding antibodies

Serologic and molecular characteristics of hepatitis B virus infection in vaccinated schizophrenia patients in China

Contact Info

Product

Resources

About