Coexistence of gastrointestinal stromal tumors with other neoplasms

Liszka, Łukasz; Zielińska-Pająk, Ewa; Pająk, Jacek; Gołka, Dariusz; Huszno, Joanna

doi:10.1007/s00535-007-2082-4

Cited by 89 publications

(82 citation statements)

References 63 publications

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“…Contrary to the majority of previous cases of synchronous GISTs and other malignancies (9,10), and the other case report of synchronous GIST and pancreatic adenocarcinoma (8), in our case, GIST was not an incidental finding. Our initial impression was a symptomatic GIST; however, following reevaluation via a CT scan with a multidisciplinary approach, a pancreatic adenocarcinoma was suspected.…”

Section: Discussioncontrasting

confidence: 99%

“…Agaimy and Wuensch analyzed a series of 97 cases of surgically resected GIST and revealed that the majority of GISTs in their series were benign or low-risk and appeared to be innocent bystanders (2). Liszka et al identified that these GISTs tended to be an incidental findings during surgery, and were most commonly localized in the small intestine (10). In our case, the GIST was associated with an intermediate risk and located in the stomach.…”

Section: Discussionsupporting

confidence: 45%

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Adenosquamous carcinoma of the uncinate process of the pancreas with synchronous gastrointestinal stromal tumor of the stomach: Case report and review of the literature

Ding

Zheng

et al. 2012

Oncology Letters

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Abstract.Recently, the coexistence of gastrointestinal stromal tumors (GISTs) with other neoplasms has been studied with increasing frequency. Coexistence of pancreatic cancer with GISTs remains a rarity; however, here, we report a very rare case of adenosquamous carcinoma (ASC) of the uncinate process of the pancreas with synchronous GISTs of the stomach in a 62-year-old female. The patient presented with epigastric discomfort and vomiting. Radiographic imaging revealed two masses; one located at the body of the stomach and the other located at the uncinate process of the pancreas. Intraoperatively, a fine needle aspiration biopsy was conducted in the uncinate process of the pancreas, which revealed the malignancy of the masses. A pancreaticoduodenectomy and partial gastrectomy were then conducted, and subsequent pathological examinations identified an ASC of the pancreas and a GIST of the stomach. In our case, contrary to the majority of previous cases of synchronous GISTs and other malignancies, GIST was not an incidental finding. The initial suspicion on the GIST as the underlying cause of clinical symptoms led to the discovery of the ASC of the uncinate process of the pancreas. IntroductionRecently, the synchronous occurrence of primary neoplasms has been studied with increasing frequency, which may be due to the improved preoperative imaging capabilities. The coexistence of gastrointestinal stromal tumors (GISTs) with other gastrointestinal or non-gastrointestinal malignancies has also been studied with increasing frequency, although the occurrence remains rare (1). It has been identified that the overall frequency of second tumors in different sites among patients with GISTs ranges between 4.5 and 18.6%, with a mean of 13% (2).GISTs are the most common type of mesenchymal tumor of the gastrointestinal tract, which most likely arise from precursor interstitial cells of Cajal. The majority of GISTs occur as a single lesion. They are common in the stomach (60-70% of all cases) and small intestine (30%), while they rarely occur in the rectum (5%), esophagus, colon, pancreas, appendix, omentum, mesentery and retroperitoneum (3). The best survival predictors are the size, location and mitotic rate of the tumor.Pancreatic cancer is a common gastrointestinal malignancy. Ductal adenocarcinoma accounts for 80-85% of pancreatic tumors, while adenosquamous carcinoma (ASC) of the pancreas is a rare, aggressive variant of pancreatic carcinoma with a worse prognosis. Its exact incidence is not known; however, autopsy and surgical specimen findings suggest that this lesion accounts for 1-4% of all exocrine malignancies of the pancreas (4).The uncinate process is a hook-like extension of the lower part of the pancreatic head that projects medially and wraps around the superior mesenteric vessels. Carcinoma in the uncinate process of the pancreas (CUPP) appears to be less common than that in other parts of the pancreas. Previous studies identify an incidence rate of 2.5% (3/119) (5), 7.7% (39/506) (6) and 10.7% (6/56) (7) ...

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Section: Discussioncontrasting

confidence: 99%

Section: Discussionsupporting

confidence: 45%

Adenosquamous carcinoma of the uncinate process of the pancreas with synchronous gastrointestinal stromal tumor of the stomach: Case report and review of the literature

Ding

Zheng

et al. 2012

Oncology Letters

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“…Liszka et al [6] reported that during this association, the stromal tumor is generally small in size, often less than 2 cm and presents a low risk of invasion and recidivism compared to isolated GIST, with a mitotic index often less than 5 and a Ki-67 less than 5% [4], suggesting a probable inhibition of the malignancy of the stromal tumor by adenocarcinoma.…”

Section: Discussionmentioning

confidence: 97%

Gastric Synchronous Stromal Tumor and Adenocarcinoma: A Fortuitous Association?

Anis¹,

Kacem²,

Amine³

et al. 2017

J Clin Exp Pathol

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The association of an adenocarcinoma with a stromal tumor in the stomach is rarely observed. We report the observation of a patient operated for a synchronous tumor associating subcardial adenocarcinoma with a stromal tumor of the gastric body. It is a 74 year-old patient, diabetic, who was admitted, in December 2016, for epigastralgia associated with vomiting evolving for 2 months. Physical examination was strictly normal. An oesogastroduodenal fibroscopy was performed showing a subcardial ulcerative budding formation with a 3 cm diameter and the presence, in the gastric body, of a second sub mucosal nodular formation with a 4 cm diameter. The anatomopathological examination of the biopsies concluded to an infiltrating and slightly differentiated adenocarcinoma at the subcardial level associated with chronic HP+ gastritis without signs of malignancy. The computed tomography, performed as part of the extension study, revealed a macro-lobulated tissue mass, posterior, pre-pyloric, with submucosal development, prolapsed in the peritoneum whose enhancement characteristics evoke a stromal tumor but also an irregular gastric cardio-tuberosal thickening predominant on the small gastric curvature and associated with necrotic pre-gastric centimetric satellite ganglia. The patient had a total gastrectomy with lymph node dissection type D1, 5 and oesojejunal anastomosis on a Y-shaped loop. The anatomo-pathological examination of the surgical specimen concluded to a slightly differentiated adenocarcinoma of the cardia classified as pT3N2 associated with a stromal tumor of the gastric body Synchronous development of gastric adenocarcinoma and GIST is rare. During this association, the stromal tumor is often characterized by low risk of recidivism.

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“…Według klasyfikacji Laurena wyróżnia się typ jelitowy (I), rozlany (II) oraz mieszany (III). Guzy stromalne (gastrointestinal stromal tumor -GIST) oraz raki endokrynne żołądka są znacznie rzadsze, pomimo iż 60% GIST zlokalizowanych jest w żołądku [1][2][3][4][5][6][7][8][9][10]. W niniejszej publikacji autorzy przedstawiają bardzo rzadką sytuację, w której stwierdzono trzy różne typy histologiczne współistniejących ze sobą guzów w jednym narządzie [1][2][3][4][5][6][7][8][9][10].…”

Section: Wstępunclassified

A rare case of simultaneous presence of adenocarcinoma, gastrointestinal stromal tumour and carcinoid tumour in the stomach

Zaręba¹,

Kamocki²,

Hołody-Zaręba³

et al. 2010

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Coexistence of gastrointestinal stromal tumors with other neoplasms

Cited by 89 publications

References 63 publications

Adenosquamous carcinoma of the uncinate process of the pancreas with synchronous gastrointestinal stromal tumor of the stomach: Case report and review of the literature

Adenosquamous carcinoma of the uncinate process of the pancreas with synchronous gastrointestinal stromal tumor of the stomach: Case report and review of the literature

Gastric Synchronous Stromal Tumor and Adenocarcinoma: A Fortuitous Association?

A rare case of simultaneous presence of adenocarcinoma, gastrointestinal stromal tumour and carcinoid tumour in the stomach

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