Coexistence of EBV associated nasopharyngeal undifferentiated carcinoma and gastric lymphoepithelioma-like carcinoma

Lee, Sun-Mi; Oh, Young Lyun; Kim, Kyoung‐Mee; Ko, Young Hyeh; Lee, Jeeyun

doi:10.3109/00313025.2010.523686

Cited by 3 publications

(4 citation statements)

References 7 publications

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“…EBV has been regarded as essential in LELC tumorigenesis, even though the underlying mechanism remains unknown [21, 22, 28, 30]. Circulating serum EBV DNA or EBV antibody has been proved to be found in nasopharyngeal, gastric LELC patients [3, 38]. However, the positive rate of EBER staining in tumor tissues is usually higher than that in serum [12, 39].…”

Section: Discussionmentioning

confidence: 99%

Primary pulmonary lymphoepithelioma-like carcinoma: a rare type of lung cancer with a favorable outcome in comparison to squamous carcinoma

Chen

Zhou

et al. 2019

Respir Res

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BackgroundPrimary pulmonary lymphoepithelioma-like carcinoma (LELC) is a rare tumor and often misdiagnosed as squamous carcinoma. In the current study, clinical characteristics and outcome of primary pulmonary LELC were systematically compared with pulmonary squamous carcinoma.MethodsForty-two cases of primary pulmonary LELC and 134 squamous carcinomas were enrolled retrospectively. Characteristic and prognosis difference between the two groups was compared, and the independent prognostic factor for pulmonary LELC was identified as well.ResultsIn comparison to squamous carcinoma, pulmonary LELC was more common in women with a younger median age and less smokers. LELC seemed to be smaller in diameter on computed tomography (CT) scans than squamous carcinoma, with scarce spiculation and vascular convergence signs. Epstein-Bar virus-encoded RNA (EBER) by in-situ hybridization was detected in 33 LELC cases, among whom 27 ones were positive in serum EBV-DNA examination. LELC patients presented a much longer median progression-free survival (PFS) than squamous carcinoma. Positive serum EBV-DNA, distant lymph node invasion, advanced clinical stage and receiving radiotherapy were correlated with the shorter PFS in LELC patients. However, only positive serum EBV-DNA was the independent PFS predictor.ConclusionPulmonary LELC looks like distinct from squamous carcinoma. Middle-aged women and nonsmokers are comparatively predominated. CT features of pulmonary LELC are relatively less-malignant. Correspondently, the progression of pulmonary LELC is seemingly favorable than squamous carcinoma and the positive serum EBV-DNA appears to be the predictor of PFS.

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Section: Discussionmentioning

confidence: 99%

Primary pulmonary lymphoepithelioma-like carcinoma: a rare type of lung cancer with a favorable outcome in comparison to squamous carcinoma

Chen

Zhou

et al. 2019

Respir Res

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“…In their study, polymerase chain reaction studies confirmed that the same viral strain infected both the stomach and jejunal tumors, suggesting that EBV may have played a role in large cell transformation. Lee et al [7] found an EBV-associated nasopharyngeal undifferentiated carcinoma case of simultaneous LELGC, demonstrated that EBV infection was closely correlated with the 2 kinds of malignant tumors. Therefore, Lee et al [7] suggested that the mechanism of occurrence and progress in both the 2 tumors was similar.…”

Section: Discussionmentioning

confidence: 99%

“…Lee et al [7] found an EBV-associated nasopharyngeal undifferentiated carcinoma case of simultaneous LELGC, demonstrated that EBV infection was closely correlated with the 2 kinds of malignant tumors. Therefore, Lee et al [7] suggested that the mechanism of occurrence and progress in both the 2 tumors was similar. Patients with HIV have weakened immune systems.…”

Section: Discussionmentioning

confidence: 99%

CT findings and clinical features of Epstein–Barr virus-associated lymphoepithelioma-like gastric carcinoma

Liang¹,

Ren²,

Gao³

et al. 2019

Medicine

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Epstein–Barr virus (EBV)-associated lymphoepithelioma-like gastric carcinoma (LELGC) is a rare primary stomach tumor, which has overlapping imaging features with mass forming gastric carcinoma (GC). The aim of our study was to present the computed tomography (CT) findings and clinical features of EBV-associated LELGC to increase awareness of this entity. The CT findings and clinical features of 4 patients with pathologically documented EBV-associated LELGC were retrospectively analyzed. Among the 4 patients, 3 were male, and 1 was female. The medium age was 51 years old. All cases were single lesions including 1 was in the gastric cardia, 1 was in the gastric body, and 2 were in the gastric antrum. A focal thickening of the gastric wall was conducted, with a large thickness-to-length ratio. The low-density stripe of the normal gastric wall abruptly terminated at the edge of the lesion. The CT images of 4 cases showed inhomogeneous density with the radiodensity values ranging from 25 to 48 HU. In addition, an ulcer was demonstrated with an irregular base and slightly raised borders in all cases. Enhancement after injection of contrast material was heterogeneous enhancement (n = 3) or homogeneous (n = 1). After enhancement, obvious enhancement was seen in 1 case, moderate enhancement was seen in 3 cases, with the peak value of the tumor in the portal phase. No evidence of lymph node involvement and distant invasion was observed. Although LELGC is quite rare, it should be considered in differential diagnosis of early GC, advanced GC, and lymphoma. The relatively typical CT appearance, combined the age and sex of patients, can suggest the diagnosis of LELGC.

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“…The relationship between EBV infection and gastric cancer was confirmed in the 1990s. The EBV infection rate of lymphoepithelioma-like gastric cancer is up to 80% to 100%, and there that of ordinary gastric cancer differs regionally by about 10% [5]. DNA methylation is the most cutting-edge epigenetic mechanism, in which the role of methylation-based epigenetic change in tumorigenesis is of the greatest concern.…”

Section: Introductionmentioning

confidence: 99%

Methylation of Epstein-Barr Virus-Associated Gastric Cancer Suppressor Genes

Chen¹,

Tian²,

Zhang³

2019

AJCEM

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Objective: To identify the methylation silenced tumor suppressor genes in Epstein-Barr virus (EBV)-associated gastric cancer (EBVaGC). Methods: EBV-positive (GT38, PT and SNU719) and negative (SGC7901) gastric cancer cell lines were selected and treated with 5-Aza-CdR. Then real-time fluorescence quantitative PCR was used to validate the results of microarray, and methylation-specific PCR (MSP) and bisulfite genomic sequencing (BGS) were adopted to detect the CpG island methylation levels of gene promoters. Results: The expression levels of 6 differentially expressed genes (H19, LOXL1, ARMCX2, LXN, CDH3 and MMP7) before and after 5-Aza-CdR treatment were confirmed by real-time qPCR, which are consistent with the results of microarray analysis. There were different degrees of methylation in LOXL1 gene promoter in EBVaGC. GT38 and PT were fully methylated, and SGC7901 and HGC-27 was unmethylated, suggesting that this gene is a candidate methylation silenced tumor suppressor gene. The methylation rate of LOXL1 in EBVaGC was significantly higher than that in EBV-negative gastric cancer (EBVnGC). Conclusion: The promoter region of candidate tumor suppressor gene LOXL1 shows high methylation status, indicating that EBV critically accounts for the methylation of LOXL1 gene regulatory region. EBV is involved in the pathogensis of EBVaGC that aberrant methylation occurred in promoter CpG island, which inactivates tumor suppressor genes.

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Coexistence of EBV associated nasopharyngeal undifferentiated carcinoma and gastric lymphoepithelioma-like carcinoma

Cited by 3 publications

References 7 publications

Primary pulmonary lymphoepithelioma-like carcinoma: a rare type of lung cancer with a favorable outcome in comparison to squamous carcinoma

Primary pulmonary lymphoepithelioma-like carcinoma: a rare type of lung cancer with a favorable outcome in comparison to squamous carcinoma

CT findings and clinical features of Epstein–Barr virus-associated lymphoepithelioma-like gastric carcinoma

Methylation of Epstein-Barr Virus-Associated Gastric Cancer Suppressor Genes

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