2010
DOI: 10.3109/00313025.2010.523686
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Coexistence of EBV associated nasopharyngeal undifferentiated carcinoma and gastric lymphoepithelioma-like carcinoma

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Cited by 3 publications
(4 citation statements)
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“…EBV has been regarded as essential in LELC tumorigenesis, even though the underlying mechanism remains unknown [21, 22, 28, 30]. Circulating serum EBV DNA or EBV antibody has been proved to be found in nasopharyngeal, gastric LELC patients [3, 38]. However, the positive rate of EBER staining in tumor tissues is usually higher than that in serum [12, 39].…”
Section: Discussionmentioning
confidence: 99%
“…EBV has been regarded as essential in LELC tumorigenesis, even though the underlying mechanism remains unknown [21, 22, 28, 30]. Circulating serum EBV DNA or EBV antibody has been proved to be found in nasopharyngeal, gastric LELC patients [3, 38]. However, the positive rate of EBER staining in tumor tissues is usually higher than that in serum [12, 39].…”
Section: Discussionmentioning
confidence: 99%
“…In their study, polymerase chain reaction studies confirmed that the same viral strain infected both the stomach and jejunal tumors, suggesting that EBV may have played a role in large cell transformation. Lee et al [7] found an EBV-associated nasopharyngeal undifferentiated carcinoma case of simultaneous LELGC, demonstrated that EBV infection was closely correlated with the 2 kinds of malignant tumors. Therefore, Lee et al [7] suggested that the mechanism of occurrence and progress in both the 2 tumors was similar.…”
Section: Discussionmentioning
confidence: 99%
“…Lee et al [7] found an EBV-associated nasopharyngeal undifferentiated carcinoma case of simultaneous LELGC, demonstrated that EBV infection was closely correlated with the 2 kinds of malignant tumors. Therefore, Lee et al [7] suggested that the mechanism of occurrence and progress in both the 2 tumors was similar. Patients with HIV have weakened immune systems.…”
Section: Discussionmentioning
confidence: 99%
“…The relationship between EBV infection and gastric cancer was confirmed in the 1990s. The EBV infection rate of lymphoepithelioma-like gastric cancer is up to 80% to 100%, and there that of ordinary gastric cancer differs regionally by about 10% [5]. DNA methylation is the most cutting-edge epigenetic mechanism, in which the role of methylation-based epigenetic change in tumorigenesis is of the greatest concern.…”
Section: Introductionmentioning
confidence: 99%