Coexistence of congenital long QT syndrome and autonomic dysregulation in children

Ogawa, Yoshiharu; Aiba, Takeshi; Kamei, Naosuke; Tominaga, Kazuhiro; Fujita, Hideki; Miyamoto, Yoshihiro; Tanaka, Toshikatsu; Kido, Sachiko

doi:10.1111/ped.13015

Cited by 1 publication

(1 citation statement)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Head-up tilt testing (HUTT) with the upright phase was useful for identifying repolarization abnormalities with prolongation of electrocardiographic T wave parameters independently of the changes in the heart rate in response to sympathetic stimulation, which is related to LQTS children [ 18 , 19 , 20 ].…”

Section: Discussionmentioning

confidence: 99%

Prolongation of Electrocardiographic T Wave Parameters Recorded during the Head-Up Tilt Table Test as Independent Markers of Syncope Severity in Children

Markiewicz-Łoskot

Kolarczyk

Mazurek

et al. 2020

IJERPH

View full text Add to dashboard Cite

The head-up tilt table test (HUTT) with the upright phase is used to help determine an imbalance of the sympathetic nervous system that is related to abnormal electrocardiographic repolarization in children with vasovagal syncope (VVS) and also in patients with the long QT syndrome (LQTS). The study attempted to evaluate T wave morphology and QT and TpTe (Tpeak–Tend) intervals recorded in ECG during the HUTT for a more accurate diagnosis of children with VVS. The group investigated 70 children with a negative HUTT result: 40 patients with VVS and 30 healthy volunteers without syncope. The RR interval as well as TpTe, and QTc intervals were measured in lead V5 of electrocardiogram (ECG) on admission to the hospital and during three phases of the HUTT. In syncopal children, which included 23 children with bifid or flat T waves and 17 patients with normal T waves in the upright phase, the QTc and TpTe were longer (p < 0.001) compared to the other test phases and longer (p < 0.001) than in the control group, respectively, with the risk of arrhythmias. Only in the control group, the TpTe was shorter (p < 0.001) in the upright phase than in the other tilt phases. The TpTe in the upright phase (>70 ms) was a good discriminator, and was better than the QTc (>427 ms). Prolongation of electrocardiographic TpTe and QT intervals, in addition to the (abnormal T wave morphology recorded during the HUTT, are helpful for identifying VVS children more predisposed to ventricular arrhythmias with a latent risk of LQTS. Further studies are required to assess the value of these repolarization parameters in clinical practice.

show abstract

Section: Discussionmentioning

confidence: 99%