1998
DOI: 10.1159/000040843
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Coexistence of Chronic Myelogenous Leukemia and Multiple Myeloma

Abstract: A case report of simultaneous presentation of chronic myelogenous leukemia (CML) and multiple myeloma (MM) in a 72-year-old female is described. Our case was typical of Ph1-positive and chimeric bcr-abl messenger RNA-positive CML. Furthermore, a marked IgG (κ-type) paraproteinemia was present. Fluorescence in situ hybridization showed that 97% of marrow nucleated cells were positive for bcr-abl fusion signal, when myeloma cells in the bone marrow amounted to 19.0%. In the literature survey, 4 simila… Show more

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Cited by 23 publications
(14 citation statements)
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“…Until this report, only two reports of patient BCR-ABL fusions were detected using PCR amplification and gene sequencing; however, no molecular mechanistic data regarding expressed BCR-ABL protein was previously reported in MM (28,29). The literature supports the existence of a relationship between MM and CML as well as a relationship between MM and the myeloproliferative disorders (59,60). It is important to mention that the BCR-ABL fusion was most prominent in one lot of H929 cells, but an additional high molecular band for both BCR and ABL could be detected in other lots of H929 cells from different vendors and separate academic laboratories (Fig.…”
Section: Discussionmentioning
confidence: 91%
“…Until this report, only two reports of patient BCR-ABL fusions were detected using PCR amplification and gene sequencing; however, no molecular mechanistic data regarding expressed BCR-ABL protein was previously reported in MM (28,29). The literature supports the existence of a relationship between MM and CML as well as a relationship between MM and the myeloproliferative disorders (59,60). It is important to mention that the BCR-ABL fusion was most prominent in one lot of H929 cells, but an additional high molecular band for both BCR and ABL could be detected in other lots of H929 cells from different vendors and separate academic laboratories (Fig.…”
Section: Discussionmentioning
confidence: 91%
“…It has been previously suspected [11,12,13,14,15,16,17,18,19,20,21,22,23,24,25,26,27,28,29,30,31,32,33,34,35,36,37,38,39,40,41,42,43,44,45,46,47,48,49,50,51,52,53,54,55,56,57,58,59,60,61,62,63,64,65,66,67,68,69,70,71,72,73,74,75,76,77,78,79,80,81,82,83,84,85,86,87,88,89,90,91], but not systematically evaluated and proven, that Ph – MPN-B-CLL is the most common combination in patients with two different haematological neoplasms (fig. 3; online suppl.…”
Section: Discussionmentioning
confidence: 99%
“…In the remaining patients, aberrant clonal karyotypes may include add (8), add(9), add(21), del(20q), del(11q) and del(12p) (3). In the present case, no clonal chromosome abnormalities were identified by the conventional cytogenetic method.…”
Section: Discussionmentioning
confidence: 53%