Coexistence of cervical endometriosis with premalignant and malignant gynecological pathologies: report on a series of 27 cases

Matalliotakis, Michail; Matalliotaki, Charoula; Zervou, Maria I.; Krithinakis, Konstantinos; Kalogiannidis, Ioannis; Goulielmos, George N.

doi:10.1080/03630242.2021.1991073

Cited by 4 publications

(6 citation statements)

References 21 publications

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“…Several cohort studies and meta-analyses have demonstrated that endometriosis is associated with ovarian, endometrial, breast, and thyroid cancer, and endometriosis can increase the risk of associated malignancies to various degrees [3][4][5][6]. Studies have also been reported on the association of endometriosis with HPV infection and cervical intraepithelial neoplasia [2,[16][17][18][19][20]. In this paper, we report a case of cervical endometriotic cyst complicated with HPV infection and CIN I lesion diagnosed after ovariohysterectomy for the endometriotic cyst.…”

Section: Introductionmentioning

confidence: 83%

“…According to the study by Michail matalliotakis et al, among 27 cases of cervical endometriosis, 16 cases were complicated with HPV infection, and the infection rate was 59.2% [2], which was much higher than 10% of the infection rate of the general population. Through a comprehensive search of PubMed database, four pieces of literature (187 cases in total) (Table 2 ) on the relationship between endometriosis and HPV infection were retrieved [2,[16][17][18]. The Chi-square test of the above data showed that P < 0.05.…”

Section: Recoveredmentioning

confidence: 91%

“…There is an association with HPV infection and cervical pathology in patients suffering from cervical endometriosis. However, further studies are still needed to establish the role of HPV infection in the pathogenesis of endometriosis and to study the gene polymorphisms related to CIN in MTHFR, tap, and RUNX3 genes [2]. Interestingly, a Japanese study found that the incidence of endometriosis was higher in patients undergoing cervical conization than in the general population.…”

Section: Recoveredmentioning

confidence: 99%

“…There are studies correlating cervical trauma and cervical-related surgical procedures (e.g., biopsy, cautery, conization, or curettage) with the development of cervical endometriosis [1]. Although endometriosis is considered as a benign disorder, it is reported that epidemiologic, histopathologic, and molecular data share common features with a cancerous process [2]. Several cohort studies and meta-analyses have demonstrated that endometriosis is associated with ovarian, endometrial, breast, and thyroid cancer, and endometriosis can increase the risk of associated malignancies to various degrees [3][4][5][6].…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Cervical Endometriosis Cyst Complicated with HPV Infection and CIN I:A Case and Review of Literature

Wang¹,

Xu²,

Li³

et al. 2022

Preprint

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Asymptomatic and perimenopausal women with cervical endometriosis can expect treatment; Patients with milder symptoms are usually managed conservatively with medications, and those with large lesions or significant clinical symptoms require surgery, which is curative in the vast majority of cases postoperatively. Cervical endometriosis is associated with HPV infection and cervical lesions, but further research is still needed to determine their relationship and mechanism.

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Section: Introductionmentioning

confidence: 83%

Section: Recoveredmentioning

confidence: 91%

Section: Recoveredmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Cervical Endometriosis Cyst Complicated with HPV Infection and CIN I:A Case and Review of Literature

Wang¹,

Xu²,

Li³

et al. 2022

Preprint

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“…Among women of reproductive age, HPV infection is a potential risk factor that predisposes them to subsequent infertility [ 4 ], and it infects skin and mucosal and cutaneous epithelial cells [ 5 ]. HPV infection is highly correlated with precancerous and cancerous lesions of the cervix uteri, vulva, vagina, penis, and anogenital areas [ 3 , 6 , 7 ], and some studies indicate that HPV is detectable in cervical endometriotic and ovarian lesion tissues [ 8 , 9 ].…”

Section: Introductionmentioning

confidence: 99%

Prevalence of Human Papillomavirus Infection in the Female Partner of Infertile Couples Undergoing IVF/ICSI-ET and Subsequent Reproductive Outcomes

Wei

Wang

Cheng

et al. 2022

JCM

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We investigated the prevalence of human papillomavirus (HPV) infection in the female partner of infertile couples and the reproductive outcomes after in vitro fertilization/intracytoplasmic sperm injection-embryo transfer (IVF/ICSI-ET). We conducted a retrospective analysis on 8117 women from infertile couples who underwent IVF/ICSI treatment and evaluated the prevalence of HPV infection in these women. The prevalence of HPV infection in the female partner of infertile couples was 9.2% (747/8117). These HPV-infected female patients undergoing ART were divided into high-risk HPV (hrHPV) (n = 130) and low-risk HPV (lrHPV) groups (n = 94), and non-infected women patients formed the negative group (n = 126). Of the 747 cases infected with HPV, 529 showed hrHPV infection (70.82%; primarily genotypes 16, 52, 53, 58, and 59); 175 exhibited lrHPV infection (23.43%; primarily genotypes 6, 43, 44, 55, 61, and 81); and 43 cases were co-infected with hrHPV and lrHPV (5.76%). Except for the Day-3 high-quality embryo rate, there were no differences in ovum maturation, fertilization, implantation, clinical pregnancy, live birth, or miscarriage rates between women infected with HPV and non-infected women (p > 0.05); however, we noted an increased miscarriage rate after logistic regression analyses (OR, 0.16; 95% CI, 0.03–0.84; p = 0.041). For single-male-factor-induced infertility in couples (smHPV), although we likewise observed no differences in ovum maturation, fertilization, or implantation rates (p > 0.05) between the smHPV group and the negative group, we discerned diminutions in the Day-3 high-quality embryo rate (46.01% vs. 70.04%, p = 0.013), clinical pregnancy rate (46.67% vs. 57.94%, p = 0.003), and live birth rate (33.33% vs. 46.83%, p = 0.027) as well as an augmented miscarriage rate (11.11% vs. 4.76%, p = 0.003), respectively. Logistic regression analyses indicated that smHPV was a risk factor for decreased clinical pregnancy rate (OR, 4.17; 95% CI, 2.31–7.53; p < 0.001) and live birth rate (OR, 1.83; 95% CI, 0.81–2.14; p = 0.045) and elevated miscarriage rate (OR, 6.83; 95% CI, 2.22–21.00; p = 0.001). HPV infection in women was associated with increased miscarriage rate, and single-male-factor infertility influenced reproductive outcomes in couples undergoing IVF/ICSI treatment. Both were potentially due to HPV infection in the couple.

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A Rare Case of the Cervical Endometriosis and Overview of the Literature

et al. 2023

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Coexistence of cervical endometriosis with premalignant and malignant gynecological pathologies: report on a series of 27 cases

Cited by 4 publications

References 21 publications

Cervical Endometriosis Cyst Complicated with HPV Infection and CIN I:A Case and Review of Literature

Cervical Endometriosis Cyst Complicated with HPV Infection and CIN I:A Case and Review of Literature

Prevalence of Human Papillomavirus Infection in the Female Partner of Infertile Couples Undergoing IVF/ICSI-ET and Subsequent Reproductive Outcomes

A Rare Case of the Cervical Endometriosis and Overview of the Literature

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