Coexistence of central and peripheral benzodiazepine binding sites in the human pineal gland

Suranyi-Cadotte, Barbara E.; Lal, S.; Nair, N.P.V.; Lafaille, F.; Quirion, Rémi

doi:10.1016/0024-3205(87)90387-0

Cited by 19 publications

(5 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, Zhao et al (13) found no relation between cardiovascular disease (ischemic heart disease or high blood pressure) and melatonin level. Concerning drugs, benzodiazepines have been found to reduce nocturnal melatonin secretion (27,28), most likely via pineal benzodiazepine receptors (29,30).…”

Section: Discussionmentioning

confidence: 99%

Pineal volume and circadian melatonin profile in healthy volunteers: An interdisciplinary approach

Nölte

Lütkhoff

Stuck

et al. 2009

Magnetic Resonance Imaging

View full text Add to dashboard Cite

Purpose: To correlate pineal parenchyma volume (PP) to circadian melatonin profiles and to determine the 24-hour melatonin per volume of pineal tissue (MLPV). Furthermore, we compared melatonin profiles of cystic and solid glands. Methods:In 15 healthy male subjects (20 -27 years) the PP was determined using high-resolution magnetic resonance imaging (trueFISP, isotropic voxel: 0.8 mm 3 ). Melatonin plasma concentrations (MC) were determined every 2 hours for 24 hours.Results: Mean PP was 125 Ϯ 54 mm 3 . PP correlated linearly to maximum MC and to 24-hour melatonin (r ϭ 0.61 and r ϭ 0.64, P Ͻ 0.05) but not to minimum MC. The 24-hour melatonin was 653 Ϯ 242.6 pg/mL, MLPV was 5.8 Ϯ 2.3 pg/mL*ml Ϫ1 . Nine pineal glands were solid and six were cystic. PP of solid glands showed higher linear correlations to maximum melatonin, to 24-hour melatonin, and to the slope of the melatonin increase of the curve (P Ͻ 0.05). Conclusion:PP correlates linearly to melatonin plasma concentrations in humans. MLPV displays similar interindividual differences as 24-hour melatonin. PP of solid glands show better correlation to melatonin profiles than cystic.

show abstract

Section: Discussionmentioning

confidence: 99%

Pineal volume and circadian melatonin profile in healthy volunteers: An interdisciplinary approach

Nölte

Lütkhoff

Stuck

et al. 2009

Magnetic Resonance Imaging

View full text Add to dashboard Cite

show abstract

“…These interactions between melatonin and BNZ have been used for reversal BNZ tolerance. Human pineal gland has both central and mitochondrial BNZ receptors [20], and it was reported that BNZ decrease melatonin production [7] inhibiting N‐acetyl‐5‐methoxytryptamine activity (NAT), the key enzyme for its synthesis.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of plasma levels of melatonin after midazolam or sodium thiopental anesthesia in children

Muñóz-Hoyos

Heredia

Moreno

et al. 2002

Journal of Pineal Research

View full text Add to dashboard Cite

Midazolam and sodium thiopental are two commonly used drugs in anesthesia for minor surgical procedures in children. A relationship exists between benzodiazepines (BNZ), barbiturates and melatonin. Whereas these drugs increase pineal melatonin production, the indoleamine amplifies the effects of both BNZ and barbiturates on the central nervous system (CNS). Our purpose was thus to analyze the plasma levels of melatonin before and during midazolam or sodium thiopental anesthesia in children subjected to ambulatory surgical procedures. Midazolam (0.4 mg/kg) or sodium thiopental (5 mg/kg) were administered i.v. to 33 and 32 children (aged between 2 and 14 yr), respectively, and blood samples were taken before and 5, 10 and 20 min after the drugs were administered. Melatonin was measured in plasma by a commercial radioimmunoassay kit previously standardized in our laboratory. The results showed that neither midazolam nor sodium thiopental anesthesia significantly affected the levels of melatonin studied at anytime. Significant correlations were found comparing the levels of melatonin between the different times studied. These results suggest that midazolam or sodium thiopental did not affect melatonin production by the pineal gland, thus avoiding a possible potentiating effect of the indoleamine on the central effects of these drugs during anesthesia. However, the possibility that changes in melatonin had been masked by the antioxidant role of the neurohormone are discussed.

show abstract

“…Several investigations have been undertaken to elucidate the relationship between melatonin and diazepam (Zatz and Brownstein 1979;Matthew et al 1984;Lowenstein et al 1985;Morton 1986;Oxenkrug and Harris 1988;Monteleone et al 1989;Wakabayashi et al 1989Wakabayashi et al , 1991aWakabayashi et al , 1991bOxenkrug and Requintina 1990;Winters et al 1991;Atsmon et al 1996). Benzodiazepine receptors are divided into high affinity (nM) "central" and lower (µM) affinity "peripheral" receptors (Iversen 1978;Surany-Cadotte et al 1987). The rat pineal gland is considered to have peripheral-type receptors (Mattew et al 1984;Lowenstein et al 1985), while bovine and human pineal glands are thought to have both peripheral and central types (Lowenstein et al 1984;Surany-Cadotte et al 1987).…”

Section: Introductionmentioning

confidence: 99%

“…Benzodiazepine receptors are divided into high affinity (nM) "central" and lower (µM) affinity "peripheral" receptors (Iversen 1978;Surany-Cadotte et al 1987). The rat pineal gland is considered to have peripheral-type receptors (Mattew et al 1984;Lowenstein et al 1985), while bovine and human pineal glands are thought to have both peripheral and central types (Lowenstein et al 1984;Surany-Cadotte et al 1987). Several in vivo studies in humans and rodents suggest that administration of diazepam alters pineal function, and consequently melatonin biosynthesis (Zatz and Brownstein 1979;Morton 1986;Oxenkrug and Harris 1988;Monteleone et al 1989;Wakabayashi et al 1989Wakabayashi et al , 1991aWakabayashi et al , 1991bOxenkrug and Requintina 1990;Winters et al 1991).…”

Section: Introductionmentioning

confidence: 99%

Chronic diazepam administration differentially affects melatonin synthesis in rat pineal and Harderian glands

Djeridane¹,

Touitou²

2001

Psychopharmacology

View full text Add to dashboard Cite

show abstract

Coexistence of central and peripheral benzodiazepine binding sites in the human pineal gland

Cited by 19 publications

References 29 publications

Pineal volume and circadian melatonin profile in healthy volunteers: An interdisciplinary approach

Pineal volume and circadian melatonin profile in healthy volunteers: An interdisciplinary approach

Evaluation of plasma levels of melatonin after midazolam or sodium thiopental anesthesia in children

Chronic diazepam administration differentially affects melatonin synthesis in rat pineal and Harderian glands

Contact Info

Product

Resources

About