Coexistence of carbon monoxide intoxication and COVID-19

Abstract

Introduction
 This case report aimed to report two patients admitted to the emergency department with a preliminary diagnosis of carbon monoxide intoxication and was diagnosed with COVID-19 during their follow-up.
 Case 1
 A 73-year-old female patient presented with weakness and shortness of breath complaints to the emergency department. Carboxyhemoglobin (COhgb) reached 36.2 %. Atypical pneumonic infiltration with peripheral and central patchy consolidations in the zones in hemothorax images from computerized tomography. The patient was tested positive for COVID-19 after a PCR test. The COhgb values of the patient reached 16 % after 3 h. Then, it dropped to 3.0 % after 8 h.
 Case 2
 A 77-year-old male patient presented with shortness of breath and nausea complaints to the emergency department. COhgb (carboxyhemoglobin) reached 30%. Emphysematous changes in the lung parenchyma and increased peribronchial densities in the lobes were shown in computed tomography. The patient was tested positive for COVID-19 after a PCR test. The COhgb values of the patient reached 13 after 3 h. It dropped to 2.4 after 8 h. 
 Conclusion
 Carbon monoxide intoxication is a significant public health problem with a high probability of death. Detailed studies and meta-analyses are needed to affect the prognosis of COVID-19 disease.

Review of Medical Studies on COVID-19 During the Pandemic Period

“…In a study, it was found that CoHb levels were higher in patients with bacterial sepsis than in patients hospitalized due to COVID-19. 53 - 56 In a study investigating the relationship between insulin-like growth factor-binding protein 5 (IGFBP5) expression and plasma osteopontin (OPN) levels and disease severity in COVID-19 patients, high OPN levels and low IGFBP5 levels were found to be associated with disease severity. 57 In a study examining the relationship between monocyte chemoattractant protein-1 and surfactant protein A levels and the clinical course and prognosis of COVID-19, both biomarkers showed a positive correlation with disease severity.…”