Coexistence of antiphospholipid antibodies and cephalalgia

Islam, Asiful; Alam, Fahmida; Gan, Siew Hua; Cavestro, Cinzia; Wong, Kah Keng

doi:10.1177/0333102417694881

Cited by 8 publications

(5 citation statements)

References 82 publications

(109 reference statements)

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“…This discrepancy has been challenged by a recent systematic review re-analysing 11 case-control studies published between 1991 and 2014. The authors found a significantly increased rate of APLs in migraineurs ( n = 170/779, 21.8%), when compared to healthy controls ( n = 63/741, 8.5%) ( p < 0.0001) [ 253 ].…”

Section: Headache and Connectivitismentioning

confidence: 99%

Headache and immunological/autoimmune disorders: a comprehensive review of available epidemiological evidence with insights on potential underlying mechanisms

Biscetti

Vanna

Cresta

et al. 2021

J Neuroinflammation

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Several lines of evidence support a role of the immune system in headache pathogenesis, with particular regard to migraine. Firstly, alterations in cytokine profile and in lymphocyte subsets have been reported in headache patients. Secondly, several genetic and environmental pathogenic factors seem to be frequently shared by headache and immunological/autoimmune diseases. Accordingly, immunological alterations in primary headaches, in particular in migraine, have been suggested to predispose some patients to the development of immunological and autoimmune diseases. On the other hand, pathogenic mechanisms underlying autoimmune disorders, in some cases, seem to favour the onset of headache. Therefore, an association between headache and immunological/autoimmune disorders has been thoroughly investigated in the last years. The knowledge of this possible association may have relevant implications in the clinical practice when deciding diagnostic and therapeutic approaches. The present review summarizes findings to date regarding the plausible relationship between headache and immunological/autoimmune disorders, starting from a description of immunological alteration of primary headaches, and moving onward to the evidence supporting a potential link between headache and each specific autoimmune/immunological disease.

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Section: Headache and Connectivitismentioning

confidence: 99%

Headache and immunological/autoimmune disorders: a comprehensive review of available epidemiological evidence with insights on potential underlying mechanisms

Biscetti

Vanna

Cresta

et al. 2021

J Neuroinflammation

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“…In APS, presence of antiphospholipid antibodies (aPLs) (autoantibodies which react against anionic phospholipids and proteins on plasma membranes) namely anticardiolipin (aCL) antibody, anti-β2-glycoprotein I (β2GPI) antibody and lupus anticoagulant (LA) are found persistently in high titers ( Miyakis et al, 2006 ; Giannakopoulos and Krilis, 2013 ). Presence of aPLs in high titers was also observed in APS patients suffering from different neurologic disorders including dementia ( Islam et al, 2016 , 2017a ). Dementia has been observed in up to 56% APS patients ( Chapman et al, 2002 ; Gomez-Puerta et al, 2005 ), and a study on non-SLE patients with neurological symptoms showed that over 50% of the patients with high levels of aPLs developed dementia ( Inzelberg et al, 1992 ).…”

Section: Introductionmentioning

confidence: 84%

Presence of Anticardiolipin Antibodies in Patients with Dementia: A Systematic Review and Meta-Analysis

Islam

Alam

Kamal

et al. 2017

Front. Aging Neurosci.

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Growing evidences are supporting towards the involvement of antiphospholipid antibodies [aPLs e.g., lupus anticoagulant (LA), anticardiolipin (aCL) and anti-β2-glycoprotein I (anti-β2-GPI) antibodies] in various neurological manifestations including migraine, epilepsy and dementia in the presence or absence of autoimmune diseases such as antiphospholipid syndrome or systemic lupus erythematosus. The aim of this systematic review and meta-analysis was to assess the presence of aPLs in dementia patients without a diagnosis of any autoimmune disease. Electronic databases (e.g., PubMed, Web of Science, Scopus, ScienceDirect and Google Scholar) were searched without any year or language restrictions and based on the inclusion criteria, nine prospective case-control studies assessing only aCL were included involving 372 dementia patients and 337 healthy controls. No studies were found to assess the presence of both LA or anti-β2-GPI. The study-specific odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using random-effects model. We observed the prevalence of aCL in dementia was higher (32.80%) than that of controls (9.50%) e.g., 3.45 times higher risk of presenting with dementia than the controls, and significant presence of aCL antibodies was detected in dementia patients compared to controls (OR: 4.94, 95% CI: 2.66 – 9.16, p < 0.00001; I2 = 32%, p = 0.16). Publication bias was not observed from Egger’s (p = 0.081) and Begg’s tests (p = 0.180). Based on the study quality assessment using modified Newcastle–Ottawa Scale for case-control studies, seven of nine studies were of high methodological quality scoring ≥ 7 (median value). In summary, aCL antibodies were significantly present in dementia patients suggesting that aCL antibodies are generated due to the autoimmune-derived effects of dementia or there might be a potential causative role of this autoantibody in dementia pathogenesis.

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“…The probabilities of these conditions in this class are much higher than the underlying cohort prevalence, and are only exceeded by the probabilities in the “Most comorbidities” class (Class 7). Hypercoagulability is a risk factor for deep vein thrombosis and pulmonary emboli; antiphospholipid antibody syndromes are well known hypercoagulable states also associated with migraine (52,53).…”

Section: Discussionmentioning

confidence: 99%

A population-health approach to characterizing migraine by comorbidity: Results from the Mindfulness and Migraine Cohort Study

et al. 2022

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Background The heterogeneity of migraine has been reported extensively, with identified subgroups usually based on symptoms. Grouping individuals with migraine and similar comorbidity profiles has been suggested, however such segmentation methods have not been tested using real-world clinical data. Objective To gain insights into natural groupings of patients with migraine using latent class analysis based on electronic health record-determined comorbidities. Methods Retrospective electronic health record data analysis of primary-care patients at Sutter Health, a large open healthcare system in Northern California, USA. We identified migraine patients over a five-year time period (2015–2019) and extracted 29 comorbidities. We then applied latent class analysis to identify comorbidity-based natural subgroups. Results We identified 95,563 patients with migraine and found seven latent classes, summarized by their predominant comorbidities and population share: fewest comorbidities (61.8%), psychiatric (18.3%), some comorbidities (10.0%), most comorbidities – no cardiovascular (3.6%), vascular (3.1%), autoimmune/joint/pain (2.2%), and most comorbidities (1.0%). We found minimal demographic differences across classes. Conclusion Our study found groupings of migraine patients based on comorbidity that have the potential to be used to guide targeted treatment strategies and the development of new therapies.

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Coexistence of antiphospholipid antibodies and cephalalgia

Cited by 8 publications

References 82 publications

Headache and immunological/autoimmune disorders: a comprehensive review of available epidemiological evidence with insights on potential underlying mechanisms

Headache and immunological/autoimmune disorders: a comprehensive review of available epidemiological evidence with insights on potential underlying mechanisms

Presence of Anticardiolipin Antibodies in Patients with Dementia: A Systematic Review and Meta-Analysis

A population-health approach to characterizing migraine by comorbidity: Results from the Mindfulness and Migraine Cohort Study

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