Coexistence of anti-melanoma differentiation-associated gene 5 and anti-aminoacyl-transfer RNA synthetase antibodies in a patient with dermatomyositis and rapidly progressive and relapsing interstitial lung disease

Double anti-PL-7 and anti-MDA-5 positive Amyopathic Dermatomyositis with rapidly progressive interstitial lung disease in a Hispanic patient

“…We only found two reported cases in Japan with double MSAs. The first one has anti-PL-7(threonyl) and anti-MDA5, and the second case with anti-EJ (glycyl) and anti-MDA5 [3,4]. We report our case of a Hispanic patient instead of Asian descent as described in prior case reports, in addition to being possibly the first reported double-positive MSA-CADM case in the United States.…”

“…In the case reported by Naniwa et al, they described a patient who tested positive for PL-7 and MDA5 antibodies and had chest CT features of the corresponding antibodies at the time of onset for RPILD, which had improved pulmonary function after high dose of IVIG [3]. In another case written by Takeuchi et al, their patient's double MSAs dermatomyositis-ILD was associated with anti-EJ and anti-MDA5 antibodies.…”

“…Such studies may lead to further insight into the pathogenesis of myositis and whether differences in profile patterns translate into varying clinically outcomes. Table 2 Comparison on coexistent anti-aminoacyl-tRNA synthetase (anti-ARS)-interstitial lung disease (ILD) dermatomyositis with anti-melanoma differentiation-associated gene 5 (MDA5)-ILD dermatomyositis Naniwa et al [3] Takecuchi et al […”

A case of cancer‐associated myositis with anti‐Mi‐2 antibody: False‐positive anti‐transcriptional intermediary factor 1‐γ antibody by commercial enzyme‐linked immunosorbent assay

“…As each MSA is associated with unique clinical and histopathological features, MSAs are useful for the diagnosis and treatment of patients with myositis . However, there have been few case reports regarding the co‐existence of MSAs . Detection of the majority of MSAs requires cumbersome immunoprecipitation assays, which are feasible to perform only in special laboratories.…”

Anti-EJ, anti-MDA5 double-positive chronic clinically amyopathic dermatomyositis: a case report

“…Coexistence of anti-ARS and anti-MDA5 antibodies is rare, because MSAs are, in general, mutually exclusive [3]. Only one report has described a case of DM with both anti-ARS (anti-PL-7) and anti-MDA5 antibodies [4]. To the best of our knowledge, ours is the second case with both anti-ARS (anti-EJ) and anti-MDA5 antibodies, but is also unique in that the antibody profile and clinical phenotype changed during the long clinical course.…”