Coevolutionary phage training and Joint application delays the emergence of phage resistance in Pseudomonas aeruginosa
Mianzhi Wang,
Jingyi Wei,
Lei Jiang
et al.
Abstract:Antibiotic-resistant bacteria are current threats to available antibiotic therapies, and this has renewed interest in the therapeutic use of phage as an alternative. However, development of phage resistance has led to unsuccessful therapeutic outcomes. In the current study, we applied phage training to minimize bacterial phage resistance and to improve treatment outcome by adapting the phage to their target hosts during co-evolution. We isolated and characterized a novel Pseudomonas aeruginosa N4-like lytic ph… Show more
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