Coenzyme Q10: The Prophylactic Effect on Low Cardiac Output Following Cardiac Valve Replacement

These results are protected by a patent at the Spanish Office of Patents and Trademarks (Reference: P201131992) Objective• To determine the efficacy of coenzyme Q10 (CoQ10) in preventing renal injury in patients with lithiasis undergoing extracorporeal shockwave lithotripsy (ESWL). Patients and Methods• Prospective, randomised, double-blind, placebo-controlled clinical trial of 100 patients with renal lithiasis who were treated with ESWL.• The patients were distributed randomly into two groups receiving either placebo or CoQ10 (200 mg/day), a powerful antioxidant with vasoactive properties, orally administered during the week before ESWL and for 1 week after.• Renal dysfunction markers, vasoactive hormones, oxidative stress, plasma levels of several interleukins and vascular resistance index (VRI) using Doppler ultrasound were evaluated the week before ESWL, 2 h before ESWL and at 2 h, 24 h and 7 days after ESWL. Results• There was a significant increase in glomerular filtration (P = 0.013), as well as a decrease in the albumin/creatinine ratio and the β2-microglobulin level (P = 0.02) after 1 week of treatment in the CoQ10 group. These changes were maintained at the follow-up after ESWL.• The administration of CoQ10 was associated with improvement in vasoactive hormone parameters, VRI and interleukin levels. These improvements were maintained until the end of the follow-up period.• However, the administration of CoQ10 was not associated with significant changes in the oxidative stress parameters. Conclusion• Our results indicate that CoQ10 administration improves renal function and vasoactive and inflammation parameter values, allowing for preconditioning before the tissue insult caused by ESWL.

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“…CoQ10 dosage was 200 mg/day as per previous studies [12,13]. There were no adverse reactions to CoQ10.…”

Section: Treatmentmentioning

confidence: 99%

“…The decrease in cytokines seen after administration (9) 70 (60) (4) (11) 150 (150) (9) 50 (80) (12) PG 90 (130) 120 (140) 210 (240) (5) 290 (220) (6) 80 (100) (7) β2-microglobulin, μg/L CoQ10 1904.67 (1120) 1480.9 (265) (2) (10) 1504 (569) (9) 1643 ( …”

Section: Effect Of Coq10 On Interleukinsmentioning

confidence: 99%

The protective role of coenzyme Q10 in renal injury associated with extracorporeal shockwave lithotripsy: a randomised, placebo‐controlled clinical trial

et al. 2014

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“…Clinical applicability has been hampered by the necessity of oral administration, which takes days to increase blood and possibly tissue levels [9,10]. As a result, initial administration of oral CoQ at the time of an acute ischemic syndrome would be of no clinical benefit.…”

Section: Introductionmentioning

confidence: 99%

Acute Administration of Liposomal Coenzyme Q10Increases Myocardial Tissue Levels and Improves Tolerance to Ischemia Reperfusion Injury

Niibori

Yokoyama

Crestanello

et al. 1998

Journal of Surgical Research

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“…There is some evidence for antioxidant activity of ubiquinol also in humans (17)(18)(19). For example, it has been shown that preoperative administration of ubiquinone-10 to patients can increase the tolerance of the heart to ischemia (17) and that patients with adult respiratory distress syndrome, a condition known to be associated with oxidant stress (12), have decreased plasma levels of ubiquinol-10 and very low plasma levels of ascorbate (18).…”

mentioning

confidence: 99%

“…For example, it has been shown that preoperative administration of ubiquinone-10 to patients can increase the tolerance of the heart to ischemia (17) and that patients with adult respiratory distress syndrome, a condition known to be associated with oxidant stress (12), have decreased plasma levels of ubiquinol-10 and very low plasma levels of ascorbate (18). There are some excellent recent reviews on the function of ubiquinol as antioxidant in vitro and in vivo (19)(20)(21).…”

mentioning

confidence: 99%

Ubiquinol-10 is an effective lipid-soluble antioxidant at physiological concentrations.

Frei

Kim

Ames

1990

Proc. Natl. Acad. Sci. U.S.A.

539

264

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It is well known that ubiquinone-10 (coenzyme Q1o, ubiquinone 50) acts as an electron carrier of the respiratory chain in mitochondria. In this paper we show that ubiquinol-10, the reduced form of ubiquinone-10, also efficiently scavenges free radicals generated chemically within liposomal membranes. Ubiquinol-10 is about as effective in preventing peroxidative damage to lipids as ae-tocopherol, which is considered the best lipid-soluble antioxidant in humans. The number of radicals scavenged by each molecule of ubiquinol-10 is 1.1 under our experimental conditions. In contrast to a-tocopherol, ubiquinol-10 is not recycled by ascorbate. However, it is known that ubiquinol-10 can be recycled by electron transport carriers present in various biomembranes and possibly by some enzymes. We also show that ubiquinol-10 spares a-tocopherol when both antioxidants are present in the same liposomal membranes and that ubiquinol-10, like a-tocopherol, does not interact with reduced glutathione. Our data together with previous work on the antioxidant function of ubiquinol reported in the literature strongly suggest that ubiquinol-10 is an important physiological lipidsoluble antioxidant.

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Coenzyme Q10: The Prophylactic Effect on Low Cardiac Output Following Cardiac Valve Replacement

Cited by 46 publications

References 12 publications

The protective role of coenzyme Q10 in renal injury associated with extracorporeal shockwave lithotripsy: a randomised, placebo‐controlled clinical trial

The protective role of coenzyme Q10 in renal injury associated with extracorporeal shockwave lithotripsy: a randomised, placebo‐controlled clinical trial

Acute Administration of Liposomal Coenzyme Q10Increases Myocardial Tissue Levels and Improves Tolerance to Ischemia Reperfusion Injury

Ubiquinol-10 is an effective lipid-soluble antioxidant at physiological concentrations.

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