Coenzyme Q10 supplementation during pregnancy reduces the risk of pre‐eclampsia

Terán, Enrique; Hernandez, Isabel; Nieto, Belen; Tavara, Rosio; Ocampo, Juan Emilio; Calle, Andrés

doi:10.1016/j.ijgo.2008.11.033

Cited by 75 publications

(43 citation statements)

References 28 publications

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“…These data closely resembled the few reports about this antioxidant during human gestation Teran et al [25] who stated that CoQ 10 level decrease during pre-eclampsia.…”

Section: Discussionsupporting

confidence: 90%

Role of Heme Oxygenase, Leptin, Coenzyme Q10 and Trace Elements in Pre-eclamptic Women

Abo-Elmatty

Badawy²,

Hussein³

et al. 2012

Ind J Clin Biochem

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The objective of this study to evaluate heme oxygenase (COHb), leptin and coenzyme Q10 (CoQ10) in pre-eclamptic women. Also Zinc, copper, Iron, total iron binding capacity, Ferritin and uric acid were assessed. 120 female subjects were included in this study. They were divided into, 60 female with normal pregnancy attending the outpatient clinic, 60 pre-eclamptic patients were recruited from obstetrics and gynaecology department Elkasr El-Aini hospital. The results showed that in preeclampatic group, leptin level was significantly increased while COHb and CoQ10 was significantly decreased. It is concluded that hemeoxygenase, leptin and coenzyme CoQ10 can be considered as new markers for prediction of pre-eclampsia.

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“…These data closely resembled the few reports about this antioxidant during human gestation Teran et al [25] who stated that CoQ 10 level decrease during pre-eclampsia.…”

Section: Discussionsupporting

confidence: 90%

Role of Heme Oxygenase, Leptin, Coenzyme Q10 and Trace Elements in Pre-eclamptic Women

Abo-Elmatty

Badawy²,

Hussein³

et al. 2012

Ind J Clin Biochem

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“…There was no perinatal mortality, and the duration of pregnancy was equivalent for both groups. 67 However, the dosage used in that study was lower than the acceptable daily intake of coenzyme Q10, which has been calculated at 12 mg/kg/day, which for a 60 kg person is 720 mg/day. 58 The Council for Responsible Nutrition has determined that 1200 mg/day is the "observed safe level" of coenzyme Q10.…”

Section: Next Generation Antioxidants For Prenatal Nutrition Coenzymementioning

confidence: 80%

Current issues and perspectives in prenatal nutrition

Morrison

Elliott²,

Knuppel³

et al. 2011

RRN

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The typical American diet, characterized by energy-dense foods rich in starches, sugars, and saturated fats, and low in fruits and vegetables, is relatively unhealthy and is associated with nutritional deficiencies. Suboptimal diets for pregnant women have been associated with serious maternal medical complications (eg, iron deficiency anemia, high blood pressure, gestational diabetes, and morning sickness), as well as an increased risk of intrauterine growth restriction, birth defects, developmental delays after birth, and future chronic health problems, (eg, heart disease, type 2 diabetes, high blood pressure, and high cholesterol) during childhood, as well as later in life. Folic acid deficiency is one of the most common problems among pregnant women, and supplementation with folic acid during pregnancy has been reported to decrease the occurrence and recurrence of fetal neural tube defects. Folate supplementation beginning preconception, along with a multivitamin, at least 12 weeks prior to conception is recommended to achieve maximal risk reduction. The reported benefits of supplementing docosahexaenoic acid, an unsaturated omega-3 essential fatty acid, during pregnancy include promoting proper neurodevelopment in fetuses and infants that extends into childhood. Pregnancy is also associated with an increased susceptibility to oxidative stress, resulting from the imbalance between oxygen free radicals and the essential antioxidants that maintain homeostasis. Associated complications include preeclampsia, preterm labor, and intrauterine growth restriction. There is not enough evidence to support routine use of antioxidants, such as vitamins C and E during pregnancy, but coenzyme Q10 and lycopene are additional antioxidants under study and are yielding promising results by decreasing the occurrence of maternal complications.

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“…Supplementation with CoQ 10 reduces the risk of developing pre-eclampsia (gestational hypertension in association with significant amounts of protein in the urine) in women at risk for the condition [Teran et al, 2009]. …”

Section: Pregnancymentioning

confidence: 99%

Coenzyme Q<sub>10</sub> Therapy

Garrido-Maraver¹,

Cordero²,

et al. 2014

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For a number of years, coenzyme Q₁₀ (CoQ₁₀) was known for its key role in mitochondrial bioenergetics; later studies demonstrated its presence in other subcellular fractions and in blood plasma, and extensively investigated its antioxidant role. These 2 functions constitute the basis for supporting the clinical use of CoQ₁₀. Also, at the inner mitochondrial membrane level, CoQ₁₀ is recognized as an obligatory cofactor for the function of uncoupling proteins and a modulator of the mitochondrial transition pore. Furthermore, recent data indicate that CoQ₁₀ affects the expression of genes involved in human cell signaling, metabolism and transport, and some of the effects of CoQ₁₀ supplementation may be due to this property. CoQ₁₀ deficiencies are due to autosomal recessive mutations, mitochondrial diseases, aging-related oxidative stress and carcinogenesis processes, and also statin treatment. Many neurodegenerative disorders, diabetes, cancer, and muscular and cardiovascular diseases have been associated with low CoQ₁₀ levels as well as different ataxias and encephalomyopathies. CoQ₁₀ treatment does not cause serious adverse effects in humans and new formulations have been developed that increase CoQ₁₀ absorption and tissue distribution. Oral administration of CoQ₁₀ is a frequent antioxidant strategy in many diseases that may provide a significant symptomatic benefit.

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Coenzyme Q10 supplementation during pregnancy reduces the risk of pre‐eclampsia

Abstract: Supplementation with CoQ10 reduces the risk of developing pre-eclampsia in women at risk for the condition.

Cited by 75 publications

References 28 publications

Role of Heme Oxygenase, Leptin, Coenzyme Q10 and Trace Elements in Pre-eclamptic Women

Role of Heme Oxygenase, Leptin, Coenzyme Q10 and Trace Elements in Pre-eclamptic Women

Current issues and perspectives in prenatal nutrition

Coenzyme Q<sub>10</sub> Therapy

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