Coenzyme Q10 Supplementation and Exercise in Healthy Humans: A Systematic Review

Sarmiento, Alvaro; Díaz‐Castro, Javier; Pulido-Morán, Mario; Kajarabille, Naroa; Guisado, Rafael; Ochoa, Julio J.

doi:10.2174/1389200216666151103115654

Cited by 42 publications

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“…Thus, in our study, we observed a positive effect of a shortterm supplementation with Ubiquinol on the levels of 8-OHdG in T4 (urine) and T5 (plasma) and plasma peroxides in T4. Other studies have also shown an effect of Coenzyme Q10 on the oxidative damage to DNA and lipids in situation of strenuous exercise [10,11].…”

Section: Tablementioning

confidence: 88%

Short‐term ubiquinol supplementation reduces oxidative stress associated with strenuous exercise in healthy adults: A randomized trial

et al. 2016

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Studies about Coenzyme Q (CoQ ) supplementation on strenuous exercise are scarce, especially those related with oxidative stress associated with physical activity and virtually nonexistent with the reduced form, Ubiquinol. The objective of this study was to determine, for the first time, whether a short-term supplementation with Ubiquinol can prevent oxidative stress associated to strenuous exercise. The participants (n = 100 healthy and well trained, but not on an elite level) were classified in two groups: Ubiquinol (experimental group), and placebo group (control). The protocol consisted of conducting two identical strenuous exercise tests with a rest period between tests of 24 h. Blood and urine samples were collected from the participants before supplementation (basal value) (T1), after supplementation (2 weeks) (T2), after first physical exercise test (T3), after 24 h of rest (T4), and after second physical exercise test (T5).The increase observed in the lactate, isoprostanes, DNA damage, and hydroperoxide levels reveals the severity of the oxidative damage induced by the exercise. There was a reduction in the isoprostanes, 8-OHdG, oxidized LDL, and hydroperoxydes in the supplemented Ubiquinol group, an increase in total antioxidant status, fat soluble antioxidant (both plasma and membrane), and CAT activity. Also, NO in the Ubiquinol-supplemented group was maintained within a narrow range. Oxidative stress induced by strenuous exercise is accumulative and increases transiently in subsequent sessions of physical activity. A short-term supplementation (2 weeks) with Ubiquinol (200 mg/day) before strenuous exercise, decreases oxidative stress and increases plasma NO, fact that could improve endothelial function, energetic substrate supply, and muscle recovery after strenuous exercise. © 2016 BioFactors, 42(6):612-622, 2016.

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Section: Tablementioning

confidence: 88%

Short‐term ubiquinol supplementation reduces oxidative stress associated with strenuous exercise in healthy adults: A randomized trial

et al. 2016

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“…CoQ10 could be suitable for a muscle-protective supplementation because it has anti-inflammatory and antioxidant activity and it is intimately involved in energy production [39,40]. However, scarce studies of CoQ10 supplementation investigating its effects during strenuous physical exercise are available in the scientific literature, especially in the field of the inflammatory signaling and hematological parameters and virtually nonexistent when referring to supplementation with the reduced form of this molecule (ubiquinol) [29,39]. Both groups studied were homogeneous in terms of weight, height, blood pressure, and age.…”

Section: Discussionmentioning

confidence: 99%

“…In the current study, ubiquinol prevented the decrease in RBC, hemoglobin, and hematocrit after the first physical test, a fact that would increase oxygen delivering to tissues, especially muscles. During exercise, oxidative stress induces deleterious structural and functional changes in RBC, however, ubiquinol prevents those changes in erythrocytes, due to its antioxidant properties [29], avoiding the impairment in hematological changes such as decreases in Hb and RBC caused by strenuous exercise [11]. In addition, ubiquinol supplementation also increases NO output [32], a fact that is beneficial during physical activity, featuring a vasodilator action that helps both exercise performance and nutrient supply in muscle recovery, as well as improvement in the supply of substrates such as glucose, together facilitate the regulatory role in the immune system [57].…”

Section: Discussionmentioning

confidence: 99%

Beneficial Effect of Ubiquinol on Hematological and Inflammatory Signaling during Exercise

et al. 2020

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Strenuous exercise (any activity that expends six metabolic equivalents per minute or more causing sensations of fatigue and exhaustion to occur, inducing deleterious effects, affecting negatively different cells), induces muscle damage and hematological changes associated with high production of pro-inflammatory mediators related to muscle damage and sports anemia. The objective of this study was to determine whether short-term oral ubiquinol supplementation can prevent accumulation of inflammatory mediators and hematological impairment associated to strenuous exercise. For this purpose, 100 healthy and well-trained firemen were classified in two groups: Ubiquinol (experimental group), and placebo group (control). The protocol was two identical strenuous exercise tests with rest period between tests of 24 h. Blood samples were collected before supplementation (basal value) (T1), after supplementation (T2), after first physical exercise test (T3), after 24 h of rest (T4), and after second physical exercise test (T5). Hematological parameters, pro- and anti-inflammatory cytokines and growth factors were measured. Red blood cells (RBC), hematocrit, hemoglobin, VEGF, NO, EGF, IL-1ra, and IL-10 increased in the ubiquinol group while IL-1, IL-8, and MCP-1 decreased. Ubiquinol supplementation during high intensity exercise could modulate inflammatory signaling, expression of pro-inflammatory, and increasing some anti-inflammatory cytokines. During exercise, RBC, hemoglobin, hematocrit, VEGF, and EGF increased in ubiquinol group, revealing a possible pro-angiogenic effect, improving oxygen supply and exerting a possible protective effect on other physiological alterations.

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“…On the other hand, a placebo controlled study with supplementation of 300 mg of ubiquinol for 6 weeks significantly enhanced physical performance, which was measured as the maximum power output in young healthy trained Olympic athletes [48]. A systematic review to analyze the influence and effect of CoQ 10 supplementation on parameters related to exercise in healthy humans revealed that CoQ 10 has the potential to be used as a nutritional supplement to improve exercise capacity; however, the current literature shows a disparity and inconsistency, possibly due to differences in the CoQ 10 formulations used, dosage, timing of the supplement, exercise tests performed and study participants [49]. …”

Section: Discussionmentioning

confidence: 99%

Coenzyme Q10 Status as a Determinant of Muscular Strength in Two Independent Cohorts

et al. 2016

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Aging is associated with sarcopenia, which is a loss of skeletal muscle mass and function. Coenzyme Q10 (CoQ10) is involved in several important functions that are related to bioenergetics and protection against oxidative damage; however, the role of CoQ10 as a determinant of muscular strength is not well documented. The aim of the present study was to evaluate the determinants of muscular strength by examining hand grip force in relation to CoQ10 status, gender, age and body mass index (BMI) in two independent cohorts (n = 334, n = 967). Furthermore, peak flow as a function of respiratory muscle force was assessed. Spearman’s correlation revealed a significant positive association between CoQ10/cholesterol level and hand grip in the basic study population (p<0.01) as well as in the validation population (p<0.001). In the latter, we also found a negative correlation with the CoQ10 redox state (p<0.01), which represents a lower percentage of the reduced form of CoQ10 (ubiquinol) in subjects who exhibit a lower muscular strength. Furthermore, the age of the subjects showed a negative correlation with hand grip (p<0.001), whereas BMI was positively correlated with hand grip (p<0.01), although only in the normal weight subgroup (BMI <25 kg/m2). Analysis of the covariance (ANCOVA) with hand grip as the dependent variable revealed CoQ10/cholesterol as a determinant of muscular strength and gender as the strongest effector of hand grip. In conclusion, our data suggest that both a low CoQ10/cholesterol level and a low percentage of the reduced form of CoQ10 could be an indicator of an increased risk of sarcopenia in humans due to their negative associations to upper body muscle strength, peak flow and muscle mass.

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Coenzyme Q10 Supplementation and Exercise in Healthy Humans: A Systematic Review

Cited by 42 publications

References 0 publications

Short‐term ubiquinol supplementation reduces oxidative stress associated with strenuous exercise in healthy adults: A randomized trial

Short‐term ubiquinol supplementation reduces oxidative stress associated with strenuous exercise in healthy adults: A randomized trial

Beneficial Effect of Ubiquinol on Hematological and Inflammatory Signaling during Exercise

Coenzyme Q10 Status as a Determinant of Muscular Strength in Two Independent Cohorts

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