Coenzyme Q10 in the treatment of heart failure: A systematic review of systematic reviews

Jafari, Mehdi; Mousavi, Seyed Mahdi; Asgharzadeh, Asra; Yazdani, Neda

doi:10.1016/j.ihj.2018.01.031

Cited by 46 publications

(32 citation statements)

References 37 publications

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“…The predictor obtained an MCC value of 0.490 using all the features and obtained an MCC of 0.560 using the optimal feature subset. [1][2][3][4][5][6] are the performance evaluation indicators of the predictor: Sen represents the sensitivity; Spe represents the specificity; Pre represents the precision; ACC represents the accuracy; F1 represents the F1-measure; MCC represents the Matthews correlation coefficient (MCC). 7 The bolded parts represent the highest value of the corresponding evaluation indicator.…”

Section: The Feature Selection Resultsmentioning

confidence: 99%

“…CoQ10 tends to concentrate in organs with high energy requirements, such as the heart, liver, and kidney. Special interest in CoQ10 has arisen from the fact that it associates with many types of diseases, such as heart disease [4,5], chronic kidney disease [6,7], and cancer [8,9]. However, the pharmacology of CoQ10 is not entirely clear, and further comprehensive studies are required for clarity.…”

Section: Introductionmentioning

confidence: 99%

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Computational Identification and Analysis of Ubiquinone-Binding Proteins

Lü

Jiang

Wang

et al. 2020

Cells

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Ubiquinone is an important cofactor that plays vital and diverse roles in many biological processes. Ubiquinone-binding proteins (UBPs) are receptor proteins that dock with ubiquinones. Analyzing and identifying UBPs via a computational approach will provide insights into the pathways associated with ubiquinones. In this work, we were the first to propose a UBPs predictor (UBPs-Pred). The optimal feature subset selected from three categories of sequence-derived features was fed into the extreme gradient boosting (XGBoost) classifier, and the parameters of XGBoost were tuned by multi-objective particle swarm optimization (MOPSO). The experimental results over the independent validation demonstrated considerable prediction performance with a Matthews correlation coefficient (MCC) of 0.517. After that, we analyzed the UBPs using bioinformatics methods, including the statistics of the binding domain motifs and protein distribution, as well as an enrichment analysis of the gene ontology (GO) and the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway.

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Section: The Feature Selection Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Computational Identification and Analysis of Ubiquinone-Binding Proteins

Lü

Jiang

Wang

et al. 2020

Cells

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“…Also, it showed antidepressive effects and significantly reduced fatigue and improved ergonomic performance during exercise. 28 Other studies assessing the effect of CoQ 10 in combination with other nutrients, such as NADH, in chronic fatigue syndrome 29 and high-dose micronutrients in patients with chronic heart failure 18 have indicated significant improvement in QOL and other dimensions of health care.…”

Section: Discussionmentioning

confidence: 99%

“…15 Studies on the effectiveness of CoQ 10 on QOL in different diseases have indicated that this supplement can have a beneficial effect on QOL. [16][17][18] However, there have been few studies on breast cancer, 9 and to our knowledge, a trial evaluating the effect of CoQ 10 alone in breast cancer patients has not been done yet. Considering the high prevalence of breast cancer, in addition to its importance and effects on all life dimensions of patients, focusing on QOL as it relates to health and finding solutions to ameliorate QOL of these patients seems necessary.…”

Section: Introductionmentioning

confidence: 99%

<p>The Effect of CoQ10 Supplementation on Quality of Life in Women with Breast Cancer Undergoing Tamoxifen Therapy: A Double-Blind, Placebo-Controlled, Randomized Clinical Trial</p>

Hosseini¹,

Zahrooni²,

Ahmadzadeh³

et al. 2020

PRBM

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Background: Survival rates among breast cancer patients and the number of patients living with treatment side effects have improved, leading to increased focus on quality of life (QOL). The objective of this study was to determine the efficacy of CoQ 10 on QOL scores among breast cancer patients in Iranian undergoing tamoxifen therapy. Methods: Thirty breast cancer patients were randomized into two groups. The first group received 100 mg CoQ 10 , and the second group took fplacebo once a day for 8 weeks. QOL was evaluated by a standard QOL questionnaire and a specific questionnaire on QOL of breast cancer patients at baseline and the end of the study. Also, physical activity of patients was assessed with the IPAQ questionnaire and dietary intake determined by a 3-day dietary record. Results: The data of 30 subjects were analyzed. According to QOL C30 data, CoQ 10 led to a significant increase in physical functioning (P=0.029), emotional functioning (P=0.031), and cognitive functioning (P=0.023) compared to placebo. Symptom scales revealed a notable reduction in appetite loss in the first group (P=0.01). Global health status showed no significant changes in either study arm. On the QOL BR23, progress in functions and decline in symptoms were not statistically significant. Arm symptoms showed significant reduction (P=0.022) in patients that received placebo. Conclusion: This trial indicates that CoQ 10 supplementation has effects in ameliorating some dimensions of QOL in breast cancer patients. To generalize the results, larger and longer intervention studies are needed. Clinical Trial Registration: IRCT2015042021874N1.

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“…Moreover, it stabilizes the calcium-dependent ion channel in the myocardium. Its supplementation in patients with cardiopathies, caused by the coenzyme Q10 deficit, showed a cardioprotective effect [182] or reduced mortality in elderly subjects [183]. However, the designed clinical trials with preserved heart failure patients failed to show the benefits of coenzyme Q supplementation [184] in left ventricle dysfunction.…”

Section: Coenzyme Q10mentioning

confidence: 99%

Myocardium Metabolism in Physiological and Pathophysiological States: Implications of Epicardial Adipose Tissue and Potential Therapeutic Targets

Gandoy-Fieiras¹,

González-Juanàtey

Eiras

2020

IJMS

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The main energy substrate of adult cardiomyocytes for their contractility are the fatty acids. Its metabolism generates high ATP levels at the expense of high oxygen consumption in the mitochondria. Under low oxygen supply, they can get energy from other substrates, mainly glucose, lactate, ketone bodies, etc., but the mitochondrial dysfunction, in pathological conditions, reduces the oxidative metabolism. In consequence, fatty acids are stored into epicardial fat and its accumulation provokes inflammation, insulin resistance, and oxidative stress, which enhance the myocardium dysfunction. Some therapies focused on improvement the fatty acids entry into mitochondria have failed to demonstrate benefits on cardiovascular disorders. Oppositely, those therapies with effects on epicardial fat volume and inflammation might improve the oxidative metabolism of myocardium and might reduce the cardiovascular disease progression. This review aims at explain (a) the energy substrate adaptation of myocardium in physiological conditions, (b) the reduction of oxidative metabolism in pathological conditions and consequences on epicardial fat accumulation and insulin resistance, and (c) the reduction of cardiovascular outcomes after regulation by some therapies.

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Coenzyme Q10 in the treatment of heart failure: A systematic review of systematic reviews

Abstract: Evidence suggests that the CoQ10 supplement may be a useful tool for managing patients with heart failure.

Cited by 46 publications

References 37 publications

Computational Identification and Analysis of Ubiquinone-Binding Proteins

Computational Identification and Analysis of Ubiquinone-Binding Proteins

<p>The Effect of CoQ10 Supplementation on Quality of Life in Women with Breast Cancer Undergoing Tamoxifen Therapy: A Double-Blind, Placebo-Controlled, Randomized Clinical Trial</p>

Myocardium Metabolism in Physiological and Pathophysiological States: Implications of Epicardial Adipose Tissue and Potential Therapeutic Targets

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