Coenzyme Q10 in Cardiovascular and Metabolic Diseases: Current State of the Problem

Abstract

The burden of cardiovascular and metabolic diseases is increasing with every year. Although the management of these conditions has improved greatly over the years, it is still far from perfect. With all of this in mind, there is a need for new methods of prophylaxis and treatment. Coenzyme Q10 (CoQ10) is an essential compound of the human body. There is growing evidence that CoQ10 is tightly linked to cardiometabolic disorders. Its supplementation can be useful in a variety of chronic and acute disorders. This review analyses the role of CoQ10 in hypertension, ischemic heart disease, myocardial infarction, heart failure, viral myocarditis, cardiomyopathies, cardiac toxicity, dyslipidemia, obesity, type 2 diabetes mellitus, metabolic syndrome, cardiac procedures and resuscitation.

Implication of nuclear factor‐erythroid 2‐like 2/heme oxygenase 1 pathway in the protective effects of coenzyme Q10 against preeclampsia‐like in a rat model

“…10 Given the crucial role of coenzyme Q10 in the MRC and other mitochondrial functions, the abnormal absence of coenzyme Q10 leads to various clinical defects including hypertension, metabolic diseases, and atherosclerosis. 21,22 The therapeutic potential of coenzyme Q10 has been widely studied. 23 Recent researches have revealed the therapeutic potential of coenzyme Q10 in a variety of diseases.…”

Coenzyme Q10: Clinical Applications in Cardiovascular Diseases

“…It is associated with an increase in morbidity and mortality [113][114][115]. As underlined for HF, CoQ 10 plays an important role in the production of ATP and its bioenergetic function associated to with antioxidant and scavenge ROS function which is essential for proper heart functioning [116,117]. A meta-analysis of eight RCTs found that patients treated with CoQ 10 were significantly less likely to develop ventricular arrhythmias (OR (95% CI) 0.05 (0.01-0.31)) and to require inotropic drugs after surgery (OR 95% CI 0.47 (0.27-0.81)).…”

The Crosstalk between Cardiac Lipotoxicity and Mitochondrial Oxidative Stress in the Cardiac Alterations in Diet-Induced Obesity in Rats

“…Mitochondria are also the main source of reactive oxygen species (ROS), which can be exacerbated in different pathological conditions, including obesity [10,11]. Dysregulation of mitochondrial function in the context of obesity can participate not only in the cardiac consequences of obesity, but as well as in its metabolic ones, since the administration of a mitochondrial antioxidant was able to improve cardiac damage and improve insulin resistance in adipose tissue associated with obesity [10,[12][13][14]. Although the potential role of cardiolipotoxicity and mitochondrial oxidative stress in the cardiac damage associated with obesity is accepted, how these two mechanisms interact in this damage remains unclear.…”