Coenzyme Q10 Deficiency and Response to Supplementation in Pediatric and Adolescent Migraine

Hershey, Andrew D.; Powers, Scott W.; Vockell, Anna-Liisa B.; LeCates, Susan L.; Ellinor, Priscilla L.; Segers, A M; Burdine, Danny; Manning, Paula; Kabbouche, Marielle A.

doi:10.1111/j.1526-4610.2007.00652.x

Cited by 174 publications

(98 citation statements)

References 39 publications

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“…The authors showed that responders were 47.6% in the CoQ 10 treated group vs 14.4% in the placebo group. A positive effect of CoQ 10 was also demonstrated in a large group of pediatric patients suffering from migraine (Hershey et al, 2007).…”

Section: Neurodegenerative Diseasementioning

confidence: 73%

Coenzyme Q₁₀: multiple benefits in one ingredient

Littarru

Lambrechts

2011

OCL

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Section: Neurodegenerative Diseasementioning

confidence: 73%

Coenzyme Q₁₀: multiple benefits in one ingredient

Littarru

Lambrechts

2011

OCL

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“…30,[34][35][36][37] Based on emerging evidence, some clinicians also recommend dietary supplements that decrease inflammation (omega-3 fatty acids) and dietary supplements, such as riboflavin, magnesium, and coenzyme Q10. [38][39][40][41][42][43][44] However, some clinicians are not familiar with these therapies; therefore, they do not use them and do not inquire about them. So, little is known about the extent of their impact or use by their patients who experience HA.…”

Section: Resultsmentioning

confidence: 99%

Complementary and Conventional Medicine Use Among Youth With Recurrent Headaches

2013

PEDIATRICS

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WHAT'S KNOWN ON THIS SUBJECT: Use of complementary and alternative medicine (CAM) is increasingly common among American youth; however, information on use of CAM among youth with recurrent headache (HA) is limited. WHAT THIS STUDY ADDS:Youth across a range of chronic conditions experience HA. These youth are more likely to use CAM. Use and expenditures for conventional medical care, and increased difficulties in activity and functioning are greater for youth with HA who use CAM. RESULTS: Of the 10.6% of youth experiencing HA, 29.6% used CAM, rising to 41% for the many HA sufferers who also experienced difficulties with emotions, concentration, behavior, school attendance, or daily activities. Biologically based products (16.2%) and mind-body therapies (13.3%) were most commonly used, especially by the 86.4% of youth with HA experiencing at least 1 other chronic condition. Compared with non-CAM users, youth with HA who used CAM also had higher expenditures for and use of most types of conventional care.CONCLUSIONS: CAM use is most common among youth with HA experiencing multiple chronic conditions and difficulties in daily functioning. Associations among CAM use, multiple chronic conditions, and higher use of conventional care highlight the need for medical providers to routinely ask about CAM use to meet the complex health needs of their patients and facilitate the optimal integration of care. Research is needed to identify models for coordinating complementary and conventional care within a medical home and to understand the health benefits or risks associated with CAM use in conjunction with conventional treatments for patients with HA. Pediatrics 2013;132:e1173-e1183

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“…Determination of deficiency and consequent supplementation may result in clinical improvement. Further analysis involving more scientifically rigorous methodology will be required to confirm all those observations in any way [112].…”

Section: Miscellaneousmentioning

confidence: 99%

Coenzyme Q10 in Heart and Brain Diseases

Fedačko¹

2011

TONUTRAJ

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Abstract:Background: Several cardiovascular, neurological and other diseases are associated with coenzyme Q10( CoQ) deficiency. The objective is to evaluate possible benefits of ubiquinone supplementation in cardiovascular diseases and degenerative diseases of the brain.Methods: An internet search in PubMed, Vitasearch, In Circulation. Net, till 2008, discussions with colleagues, own experiences.Results: Ubiquinone (Coenzyme Q10 ) deficiency has been observed in several cardiovascular and neurological diseases. CoQ10 has strong influence on lipid metabolism, oxidation of blood lipids, vascular inflammation and on the cell membranes of cardiac and arterial cells and neurons. These pathogenetic mechanisms seem to be important in patients with neurological and cardiac disease as well as in brain-heart connection. Its supplementation has several beneficial effects including the stabilisation of atherosclerotic plaque and decreasing the size of myoacardial infarction and the protection of neurons. Antioxidant properties of CoQ10 are responsible for the prevention of many drug side effects. Several studies have suggested the beneficial effect of CoQ10 in neuro-cardiovascular diseases, that will require further confirmation. Adverse effects such as nausea and vomiting may be reduced by using highly bio-available brands, that reduce the oral dosage of COQ.Conclusions: CoQ10 is still in the investigational stages and the list of possible indications related to brain and heart diseases and their linkage, appears to be quite extensive. There is still the need for a number of large, double blind multicenter, randomized, controlled clinical trials, in order to confirm the possible beneficial effects of CoQ10 supplementation in different neurocardiological conditions.

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Coenzyme Q10 Deficiency and Response to Supplementation in Pediatric and Adolescent Migraine

Abstract: Deficiency of CoQ10 may be common in pediatric and adolescent migraine. Determination of deficiency and consequent supplementation may result in clinical improvement. Further analysis involving more scientifically rigorous methodology will be required to confirm this observation.

Cited by 174 publications

References 39 publications

Coenzyme Q₁₀: multiple benefits in one ingredient

Coenzyme Q₁₀: multiple benefits in one ingredient

Complementary and Conventional Medicine Use Among Youth With Recurrent Headaches

Coenzyme Q10 in Heart and Brain Diseases

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Coenzyme Q10 Deficiency and Response to Supplementation in Pediatric and Adolescent Migraine

Abstract: Deficiency of CoQ10 may be common in pediatric and adolescent migraine. Determination of deficiency and consequent supplementation may result in clinical improvement. Further analysis involving more scientifically rigorous methodology will be required to confirm this observation.

Cited by 174 publications

References 39 publications

Coenzyme Q10: multiple benefits in one ingredient

Coenzyme Q10: multiple benefits in one ingredient

Complementary and Conventional Medicine Use Among Youth With Recurrent Headaches

Coenzyme Q10 in Heart and Brain Diseases

Contact Info

Product

Resources

About

Coenzyme Q₁₀: multiple benefits in one ingredient

Coenzyme Q₁₀: multiple benefits in one ingredient