Coenzyme Q10 combined with trimetazidine in the prevention of contrast-induced nephropathy in patients with coronary heart disease complicated with renal dysfunction undergoing elective cardiac catheterization: a randomized control study and in vivo study

Abstract

BackgroundContrast-induced nephropathy (CIN) is one of the common hospital-acquired acute renal failures. The purpose of this study was to investigate whether Coenzyme Q10 (CoQ10) and trimetazidine (TMZ) can prevent the occurrence of CIN after elective cardiac catheterization in patients with coronary artery disease complicated with renal dysfunction.MethodsConsecutive coronary artery disease patients with renal insufficiency scheduled for coronary angiography were enrolled in randomized, paralleled, double-blind, controlled trial. The development of CIN was occurrence at the 48 or 72 h after the procedure. The changes of serum creatinine (SCr), eGFR, and Cys-C within 72 h after the procedure were measured and compared. In vivo contrast medium (CM)-induced acute kidney injury (AKI) animal model was established, and CoQ10 plus TMZ was orally administrated to evaluate its renal protective effect.Results150 patients with renal insufficiency were enrolled finally. CIN occurred in 21 (14.00%) of the 150 patients. 72 h after the procedure, the incidence of CIN was significantly lower in CoQ10 plus TMZ group compared with control group (6.67 vs. 21.3%, p = 0.01). No cardiac death occurred in this study. No side effects were observed after administration of CoQ10 and TMZ. In vivo test demonstrated that CoQ10 and TMZ could significantly reduce the concentration of blood urea nitrogen (BUN) and SCR induced by CM i.v. injection, as well as tubular pathological injuries. Meanwhile, CoQ10 and TMZ could significantly reduce the oxidation stress in kidneys from CM-AKI animals.ConclusionCoQ10 plus TMZ could decrease the incidence of CIN in patients with renal insufficiency undergoing elective cardiac catheterization, and their effect may be due to its strong anti-oxidation effect.

Protection of coenzyme Q10 against contrast-induced acute kidney injury in male diabetic rats

“…Corroborating with the findings of Chen et al that demonstrated the protective effect of CoQ10 in combination with trimetazidine against CI-AKI in patients with coronary heart disease complicated with renal dysfunction as well as on rat models of CI-AKI, the results of this study have demonstrated the renoprotection of CoQ10 in an experimental model of risk factor of DM for CI-AKI [ 42 ]. In the present study, CoQ10 presented an antioxidant effect on the CI-AKI in male diabetic rats by improving renal function and renal hemodynamics, preserving morphology and reducing oxidative stress.…”

In VitroEvaluation of the Biological Availability of Hyaluronic Acid Polyethylene Glycols-Cross-Linked Hydrogels to Bovine Testes Hyaluronidase

“…Despite the availability of hyaluronidases, it has being discussed whether all HA fillers are sensitive to the activity of these enzymes; in fact, several studies have shown that the resistance to degradation depends on numerous factors, such as the concentration of HA, the type and degree of cross-linking, and the cohesive properties [23–26].…”

Efficacy of Trimetazidine in Limiting Periprocedural Myocardial Injury in Patients Undergoing Percutaneous Coronary Intervention: A Systematic Review and Meta-Analysis

“…Five studies were then excluded for the following reasons: full-text not available, 20 study results not yet published, 21 patients did not undergo PCI 22 and outcomes not relevant. 23,24 Fifteen trials 10,12,13,15,[25][26][27][28][29][30][31][32][33][34][35] were included in the systematic review and 14 trials in the meta-analysis. Data were not available as mean and standard deviation from one study and hence it was not included in the meta-analysis.…”